ID:TAF2_HUMAN DESCRIPTION: RecName: Full=Transcription initiation factor TFIID subunit 2; AltName: Full=150 kDa cofactor of initiator function; AltName: Full=RNA polymerase II TBP-associated factor subunit B; AltName: Full=TBP-associated factor 150 kDa; AltName: Full=Transcription initiation factor TFIID 150 kDa subunit; Short=TAF(II)150; Short=TAFII-150; Short=TAFII150; FUNCTION: Transcription factor TFIID is one of the general factors required for accurate and regulated initiation by RNA polymerase II. TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. It requires core promoter-specific cofactors for productive transcription stimulation. TAF2 stabilizes TFIID binding to core promoter. SUBUNIT: Component of transcription factor TFIID which is composed of TBP and a number of TBP-associated factors. Interacts with TAF2C1. Component of the TFTC-HAT complex. SUBCELLULAR LOCATION: Nucleus. TISSUE SPECIFICITY: Expressed in all tissues tested. MISCELLANEOUS: PubMed:9418870 was unable to show an association between TAF2 and TFIID. SIMILARITY: Belongs to the TAF2 family. SEQUENCE CAUTION: Sequence=AAC68502.1; Type=Erroneous initiation; Sequence=AAH64830.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q6P1X5
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0001129 RNA polymerase II transcription factor activity, TBP-class protein binding, involved in preinitiation complex assembly GO:0003682 chromatin binding GO:0005515 protein binding GO:0043565 sequence-specific DNA binding GO:0044212 transcription regulatory region DNA binding GO:0001075 transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly
Biological Process: GO:0000086 G2/M transition of mitotic cell cycle GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006366 transcription from RNA polymerase II promoter GO:0006367 transcription initiation from RNA polymerase II promoter GO:0014070 response to organic cyclic compound GO:0045944 positive regulation of transcription from RNA polymerase II promoter GO:0051123 RNA polymerase II transcriptional preinitiation complex assembly GO:1901796 regulation of signal transduction by p53 class mediator
BC037262 - Homo sapiens, clone IMAGE:3924558, mRNA. AL137601 - Homo sapiens mRNA; cDNA DKFZp434E0811 (from clone DKFZp434E0811); partial cds. BC008473 - Homo sapiens, clone IMAGE:4282266, mRNA. BC018010 - Homo sapiens, clone IMAGE:4281881, mRNA. LF385041 - JP 2014500723-A/192544: Polycomb-Associated Non-Coding RNAs. AK001618 - Homo sapiens cDNA FLJ10756 fis, clone NT2RP3004572, highly similar to Homo sapiens TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 150 kDa (TAF2), mRNA. AK001909 - Homo sapiens cDNA FLJ11047 fis, clone PLACE1004510, highly similar to Homo sapiens TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 150 kDa (TAF2), mRNA. JD287109 - Sequence 268133 from Patent EP1572962. JD110215 - Sequence 91239 from Patent EP1572962. LF336623 - JP 2014500723-A/144126: Polycomb-Associated Non-Coding RNAs. JD120676 - Sequence 101700 from Patent EP1572962. JD285054 - Sequence 266078 from Patent EP1572962. JD285053 - Sequence 266077 from Patent EP1572962. JD300193 - Sequence 281217 from Patent EP1572962. JD390235 - Sequence 371259 from Patent EP1572962. JD516121 - Sequence 497145 from Patent EP1572962. JD050250 - Sequence 31274 from Patent EP1572962. JD297235 - Sequence 278259 from Patent EP1572962. AF040701 - Homo sapiens TATA binding protein associated factor (TAFII150) mRNA, complete cds. AF026445 - Homo sapiens cofactor of initiator function (CIF150) mRNA, complete cds. JD502774 - Sequence 483798 from Patent EP1572962. JD043263 - Sequence 24287 from Patent EP1572962. AF057694 - Homo sapiens TBP-associated factor TAFII150 (TAFII150) mRNA, complete cds. AK316592 - Homo sapiens cDNA, FLJ95940, highly similar to Homo sapiens TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 150kDa (TAF2), mRNA. BC146379 - Synthetic construct Homo sapiens clone IMAGE:100015121, MGC:180212 TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 150kDa (TAF2) mRNA, encodes complete protein. LF336624 - JP 2014500723-A/144127: Polycomb-Associated Non-Coding RNAs. LF336630 - JP 2014500723-A/144133: Polycomb-Associated Non-Coding RNAs. BC035673 - Homo sapiens TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 150kDa, mRNA (cDNA clone IMAGE:5741328), partial cds. BC047732 - Homo sapiens TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 150kDa, mRNA (cDNA clone IMAGE:6470186), partial cds. BC064830 - Homo sapiens TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 150kDa, mRNA (cDNA clone IMAGE:6453698), partial cds. LF336641 - JP 2014500723-A/144144: Polycomb-Associated Non-Coding RNAs. JD378147 - Sequence 359171 from Patent EP1572962. JD451974 - Sequence 432998 from Patent EP1572962. JD323109 - Sequence 304133 from Patent EP1572962. JD139190 - Sequence 120214 from Patent EP1572962. JD211325 - Sequence 192349 from Patent EP1572962. MA620618 - JP 2018138019-A/192544: Polycomb-Associated Non-Coding RNAs. MA572200 - JP 2018138019-A/144126: Polycomb-Associated Non-Coding RNAs. MA572201 - JP 2018138019-A/144127: Polycomb-Associated Non-Coding RNAs. MA572207 - JP 2018138019-A/144133: Polycomb-Associated Non-Coding RNAs. MA572218 - JP 2018138019-A/144144: Polycomb-Associated Non-Coding RNAs.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q6P1X5 (Reactome details) participates in the following event(s):
R-HSA-109636 Recognition and Binding of Core Promoter Elements by TFIID R-HSA-73946 Abortive initiation R-HSA-75856 Abortive Initiation Before Second Transition R-HSA-75873 Addition of Nucleotides 5 through 9 on the growing Transcript R-HSA-167136 Addition of nucleotides 5 through 9 on the growing HIV-1 transcript R-HSA-167474 Abortive HIV-1 Initiation Before Second Transition R-HSA-167477 Abortive HIV-1 initiation after formation of the first phosphodiester bond R-HSA-75866 Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP R-HSA-75861 NTP Binds Active Site of RNA Polymerase II R-HSA-75864 Newly Formed Phosphodiester Bond Stabilized and PPi Released R-HSA-109637 Binding of TFIIA and TFIIB to the pol II promoter:TFIID complex R-HSA-75862 Fall Back to Closed Pre-initiation Complex R-HSA-75949 RNA Polymerase II Promoter Opening: First Transition R-HSA-167134 Newly formed phosphodiester bond stabilized and PPi released R-HSA-167130 Nucleophillic attack by 3'-hydroxyl oxygen of nascent HIV-1 transcript on the Alpha phosphate of NTP R-HSA-167118 NTP binds active site of RNA Polymerase II in HIV-1 open pre-initiation complex R-HSA-167484 Fall Back to Closed Pre-initiation Complex R-HSA-167097 HIV Promoter Opening: First Transition R-HSA-6805399 TAF1 phosphorylates TP53 R-HSA-109638 Recruitment of RNA Polymerase II Holoenzyme by TFIIF to the pol II promoter:TFIID:TFIIA:TFIIB complex R-HSA-75095 Binding of TFIIE to the growing preinitiation complex R-HSA-109639 Formation of the closed pre-initiation complex R-HSA-73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-674695 RNA Polymerase II Pre-transcription Events R-HSA-73776 RNA Polymerase II Promoter Escape R-HSA-167162 RNA Polymerase II HIV Promoter Escape R-HSA-167161 HIV Transcription Initiation R-HSA-75953 RNA Polymerase II Transcription Initiation R-HSA-76042 RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-167172 Transcription of the HIV genome R-HSA-73857 RNA Polymerase II Transcription R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation R-HSA-162599 Late Phase of HIV Life Cycle R-HSA-74160 Gene expression (Transcription) R-HSA-5633007 Regulation of TP53 Activity R-HSA-162587 HIV Life Cycle R-HSA-3700989 Transcriptional Regulation by TP53 R-HSA-162906 HIV Infection R-HSA-212436 Generic Transcription Pathway R-HSA-5663205 Infectious disease R-HSA-1643685 Disease
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
