ID:TACC1_HUMAN DESCRIPTION: RecName: Full=Transforming acidic coiled-coil-containing protein 1; AltName: Full=Gastric cancer antigen Ga55; AltName: Full=Taxin-1; FUNCTION: Likely involved in the processes that promote cell division prior to the formation of differentiated tissues. SUBUNIT: Interacts with KIAA0097/CH-TOG and with the oncogenic transcription factor YEATS4. Interacts with AURKA, AURKB and AURKC. Interacts with LSM7, TDRD7 and SNRPG. Interacts with GCN5L2 and PCAF. INTERACTION: Q96GD4:AURKB; NbExp=2; IntAct=EBI-624278, EBI-624291; Q14008:CKAP5; NbExp=3; IntAct=EBI-624237, EBI-310585; Q9UK45:LSM7; NbExp=4; IntAct=EBI-624252, EBI-348372; P62308:SNRPG; NbExp=5; IntAct=EBI-624252, EBI-624585; Q8NHU6:TDRD7; NbExp=4; IntAct=EBI-624237, EBI-624505; O95619:YEATS4; NbExp=6; IntAct=EBI-624237, EBI-399269; SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, centrosome. Note=Nucleus during interphase. Weakly concentrated at centrosomes during mitosis and colocalizes with AURKC at the midbody during cytokinesis. TISSUE SPECIFICITY: Isoform 1, isoform 3 and isoform 5 are ubiquitous. Isoform 2 is strongly expressed in the brain, weakly detectable in lung and colon, and overexpressed in gastric cancer. Isoform 4 is not detected in normal tissues, but strong expression was found in gastric cancer tissues. Down-regulated in a subset of cases of breast cancer. DEVELOPMENTAL STAGE: Expressed at high level during early embryogenesis. PTM: Isoform 1 is heavily phosphorylated; isoform 6 is not. Phosphorylated upon DNA damage, probably by ATM or ATR. SIMILARITY: Belongs to the TACC family. SIMILARITY: Contains 2 SPAZ (Ser/Pro-rich AZU-1) domains. WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/TACC1ID42456ch8p11.html";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF05010 - Transforming acidic coiled-coil-containing protein (TACC), C-terminal
ModBase Predicted Comparative 3D Structure on O75410
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
