Human Gene SULT2A1 (ENST00000222002.4_7) from GENCODE V47lift37

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Description: sulfotransferase family 2A member 1 (from RefSeq NM_003167.4)
Gencode Transcript: ENST00000222002.4_7
Gencode Gene: ENSG00000105398.4_9
Transcript (Including UTRs)
Position: hg19 chr19:48,373,724-48,389,572 Size: 15,849 Total Exon Count: 6 Strand: -
Coding Region
Position: hg19 chr19:48,374,712-48,389,514 Size: 14,803 Coding Exon Count: 6

Page Index	Sequence and Links	UniProtKB Comments	Primers	MalaCards	CTD
Gene Alleles	RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species
GO Annotations	mRNA Descriptions	Pathways	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr19:48,373,724-48,389,572)			mRNA (may differ from genome)		Protein (285 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	Malacards	MGI	OMIM	PubMed	Reactome
UniProtKB	Wikipedia	BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: ST2A1_HUMAN DESCRIPTION: RecName: Full=Bile salt sulfotransferase; EC=2.8.2.14; AltName: Full=Dehydroepiandrosterone sulfotransferase; Short=DHEA-ST; AltName: Full=Hydroxysteroid Sulfotransferase; Short=HST; AltName: Full=ST2; AltName: Full=ST2A3; AltName: Full=Sulfotransferase 2A1; Short=ST2A1; FUNCTION: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfonation of steroids and bile acids in the liver and adrenal glands. CATALYTIC ACTIVITY: 3'-phosphoadenylyl sulfate + glycolithocholate = adenosine 3',5'-bisphosphate + glycolithocholate 3-sulfate. CATALYTIC ACTIVITY: 3'-phosphoadenylyl sulfate + taurolithocholate = adenosine 3',5'-bisphosphate + taurolithocholate sulfate. SUBUNIT: Homodimer. INTERACTION: P40763:STAT3; NbExp=2; IntAct=EBI-3921363, EBI-518675; SUBCELLULAR LOCATION: Cytoplasm. TISSUE SPECIFICITY: Liver, adrenal and at lower level in the kidney. Is present in human fetus in higher level in the adrenal than the liver and the kidney. PTM: The N-terminus is blocked. MISCELLANEOUS: Estrogens present in maternal circulation is predominantly derived from fetal dehydroepiandosterone sulfate which is hydrolyzed and metabolized to estrogens in placenta. SIMILARITY: Belongs to the sulfotransferase 1 family.

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
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Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
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To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

MalaCards Disease Associations


	MalaCards Gene Search: SULT2A1 Diseases sorted by gene-association score: sex differentiation disease (9), adrenal cortical adenoma (8), polycystic ovary syndrome (6), ovarian brenner tumor (5), cholangitis, primary sclerosing (4), gonadal disease (4)

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D001647 Bile Acids and Salts D003907 Dexamethasone D004997 Ethinyl Estradiol D005411 Flame Retardants D006914 Hydroxysteroids D001556 Lindane D010634 Phenobarbital D013749 Tetrachlorodibenzodioxin C006253 pirinixic acid C012277 1,2-diamino-4-nitrobenzene C049325 1,2-dithiol-3-thione C028474 1,4-bis(2-(3,5-dichloropyridyloxy))benzene C033146 1-hydroxypyrene C035314 1-nitropropane C014024 2,4,5,2',4',5'-hexachlorobiphenyl C010914 2,4-diaminotoluene C016403 2,4-dinitrotoluene C029905 2,5-dichlorobiphenyl C010925 2,5-dihydroxybenzoic acid C025235 2,6-diaminotoluene D015073 2-Acetylaminofluorene C014706 2-nitro-4-phenylenediamine C016617 2-nitropropane C081331 24-norursodeoxycholic acid C028676 4-acetylaminofluorene C032171 4-coumaric acid C082137 4-diethoxyphosphorylmethyl-N-(4-bromo-2-cyanophenyl)benzamide C002202 4-oxoretinoic acid D015124 8-Bromo Cyclic Adenosine Monophosphate D000082 Acetaminophen D016604 Aflatoxin B1 D000438 Alcohols D001205 Ascorbic Acid D001564 Benzo(a)pyrene D019826 Cholic Acid D002994 Clofibrate D003022 Clotrimazole D019327 Copper Sulfate D016572 Cyclosporine D003687 Dehydroepiandrosterone D004051 Diethylhexyl Phthalate D004052 Diethylnitrosamine D004126 Dimethylformamide D004128 Dimethylnitrosamine D004958 Estradiol D000431 Ethanol D005419 Flavonoids D005576 Forskolin C425931 GW 501516 D005707 Gallic Acid D006533 Heptachlor D006861 Hydrogen Peroxide D006881 Hydroxyacetylaminofluorene C011582 IMOL S-140 D015474 Isotretinoin C099406 L 742694 D008044 Linuron D008694 Methamphetamine D008727 Methotrexate D008748 Methylcholanthrene C002741 N-nitrosomorpholine D010100 Oxygen D015125 Oxyquinoline D017239 Paclitaxel D010278 Parathion D010672 Phenytoin D010724 Phosphoadenosine Phosphosulfate D011078 Polychlorinated Biphenyls D011285 Pregnenolone Carbonitrile D011794 Quercetin C488333 Ro 65-7199 C488334 Ro 66-0074 D013629 Tamoxifen D013963 Thyroid Hormones D014212 Tretinoin D014284 Triiodothyronine D014580 Ursodeoxycholic Acid C103303 alitretinoin C103016 antalarmin C104416 astressin D019324 beta-Naphthoflavone C095105 bexarotene C004541 biochanin A C105934 celecoxib C019304 ciprofibrate C018021 cobaltous chloride C071192 entacapone C076840 ethofenprox C004999 ferulic acid C089796 hexabromocyclododecane C016517 indole-3-carbinol C027579 periodate-oxidized adenosine C017947 sodium arsenite C066340 tolcapone C072782 tri-(2-chloroisopropyl)phosphate C005445 triphenyl phosphate C016805 tris(1,3-dichloro-2-propyl)phosphate C013320 tris(2-butoxyethyl) phosphate C031324 tris(chloroethyl)phosphate

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 241.87 RPKM in Liver Total median expression: 420.60 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-13.40	58	-0.231	Picture	PostScript	Text
3' UTR	-280.50	988	-0.284	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR000863 - Sulfotransferase_dom

Pfam Domains:
PF00685 - Sulfotransferase domain
PF13469 - Sulfotransferase family

SCOP Domains:
51905 - FAD/NAD(P)-binding domain
52540 - P-loop containing nucleoside triphosphate hydrolases

Protein Data Bank (PDB) 3-D Structure
MuPIT help

1EFH - X-ray MuPIT

1J99 - X-ray MuPIT

1OV4 - X-ray MuPIT

2QP3 - X-ray MuPIT

2QP4 - X-ray MuPIT

3F3Y - X-ray MuPIT

ModBase Predicted Comparative 3D Structure on Q06520


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	Genome Browser	No ortholog
	Gene Details			Gene Details
	Gene Sorter			Gene Sorter
	RGD			WormBase
				Protein Sequence
				Alignment

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0004062 aryl sulfotransferase activity GO:0004304 estrone sulfotransferase activity GO:0005515 protein binding GO:0008146 sulfotransferase activity GO:0016740 transferase activity GO:0047704 bile-salt sulfotransferase activity GO:0050294 steroid sulfotransferase activity Biological Process: GO:0006068 ethanol catabolic process GO:0006629 lipid metabolic process GO:0008202 steroid metabolic process GO:0016042 lipid catabolic process GO:0019216 regulation of lipid metabolic process GO:0030573 bile acid catabolic process GO:0050427 3'-phosphoadenosine 5'-phosphosulfate metabolic process GO:0051923 sulfation Cellular Component: GO:0005737 cytoplasm GO:0005829 cytosol

Descriptions from all associated GenBank mRNAs


	S43861 - ST2=alcohol/hydroxysteroid sulfotransferase {clone II} [human, liver, mRNA, 1543 nt]. U08024 - Human clone A dehydroepiandrosterone sulfotransferase (STD) mRNA, complete cds. JD126274 - Sequence 107298 from Patent EP1572962. JD389074 - Sequence 370098 from Patent EP1572962. JD457593 - Sequence 438617 from Patent EP1572962. JD335483 - Sequence 316507 from Patent EP1572962. JD310157 - Sequence 291181 from Patent EP1572962. JD360920 - Sequence 341944 from Patent EP1572962. JD384119 - Sequence 365143 from Patent EP1572962. JD389073 - Sequence 370097 from Patent EP1572962. JD440805 - Sequence 421829 from Patent EP1572962. JD472577 - Sequence 453601 from Patent EP1572962. JD257065 - Sequence 238089 from Patent EP1572962. JD199625 - Sequence 180649 from Patent EP1572962. JD112481 - Sequence 93505 from Patent EP1572962. JD485370 - Sequence 466394 from Patent EP1572962. JD220615 - Sequence 201639 from Patent EP1572962. JD119019 - Sequence 100043 from Patent EP1572962. AK289380 - Homo sapiens cDNA FLJ77905 complete cds, highly similar to Homo sapiens sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1 (SULT2A1), mRNA. JD481349 - Sequence 462373 from Patent EP1572962. JD047497 - Sequence 28521 from Patent EP1572962. JD249806 - Sequence 230830 from Patent EP1572962. JD148278 - Sequence 129302 from Patent EP1572962. JD249807 - Sequence 230831 from Patent EP1572962. JD288482 - Sequence 269506 from Patent EP1572962. JD463791 - Sequence 444815 from Patent EP1572962. JD500056 - Sequence 481080 from Patent EP1572962. JD478550 - Sequence 459574 from Patent EP1572962. JD489427 - Sequence 470451 from Patent EP1572962. JD279555 - Sequence 260579 from Patent EP1572962. JD037026 - Sequence 18050 from Patent EP1572962. U08025 - Human clone G dehydroepiandrosterone sulfotransferase (STD) mRNA, complete cds. L20000 - Human dehydroepiandrosterone sulfotransferase mRNA, complete cds. X70222 - H.sapiens mRNA for dehydroepiandrosterone sulphotransferase. BC020755 - Homo sapiens sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1, mRNA (cDNA clone MGC:22602 IMAGE:4733628), complete cds. L02337 - Human sulfotransferase-related mRNA sequence. S43859 - ST2=alcohol/hydroxysteroid sulfotransferase {clone I} [human, liver, mRNA, 1051 nt]. X84816 - H.sapiens mRNA for hydroxysteroid sulfotransferase. JD295323 - Sequence 276347 from Patent EP1572962. AK313415 - Homo sapiens cDNA, FLJ93953, highly similar to Homo sapiens sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA) -preferring, member 1 (SULT2A1), mRNA. CU676700 - Synthetic construct Homo sapiens gateway clone IMAGE:100022233 5' read SULT2A1 mRNA. DQ891165 - Synthetic construct clone IMAGE:100003795; FLH176696.01X; RZPDo839G04122D sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1 (SULT2A1) gene, encodes complete protein. DQ894346 - Synthetic construct Homo sapiens clone IMAGE:100008806; FLH176695.01L; RZPDo839G04121D sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1 (SULT2A1) gene, encodes complete protein.

Biochemical and Signaling Pathways


	Reactome (by CSHL, EBI, and GO) Protein Q06520 (Reactome details) participates in the following event(s): R-HSA-176588 lithocholate + PAPS => lithocholate sulfate + PAP R-HSA-176604 taurolithocholate + PAPS => taurolithocholate sulfate + PAP R-HSA-176631 dehydroepiandrosterone (DHEA) + PAPS => DHEA sulfate + PAP R-HSA-176585 3,5,3'-triiodothyronine + PAPS => 3,5,3'-triiodothyronine 4-sulfate + PAP R-HSA-176664 estrone + PAPS => estrone 3-sulfate + PAP R-HSA-176474 3,3'-diiodothyronine + PAPS => 3,3'-diiodothyronine 4-sulfate + PAP R-HSA-1989781 PPARA activates gene expression R-HSA-400206 Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) R-HSA-156584 Cytosolic sulfonation of small molecules R-HSA-556833 Metabolism of lipids R-HSA-156580 Phase II - Conjugation of compounds R-HSA-1430728 Metabolism R-HSA-211859 Biological oxidations

Other Names for This Gene


	Alternate Gene Symbols: ENST00000222002.1, ENST00000222002.2, ENST00000222002.3, HST, NM_003167, Q06520, ST2A1_HUMAN, STD, uc317ddf.1, uc317ddf.2 UCSC ID: ENST00000222002.4_7 RefSeq Accession: NM_003167.4 Protein: Q06520 (aka ST2A1_HUMAN or SUHA_HUMAN)

Gene Model Information


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Methods, Credits, and Use Restrictions


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