Human Gene SULT2A1 (ENST00000222002.4_7) from GENCODE V47lift37
  Description: sulfotransferase family 2A member 1 (from RefSeq NM_003167.4)
Gencode Transcript: ENST00000222002.4_7
Gencode Gene: ENSG00000105398.4_9
Transcript (Including UTRs)
   Position: hg19 chr19:48,373,724-48,389,572 Size: 15,849 Total Exon Count: 6 Strand: -
Coding Region
   Position: hg19 chr19:48,374,712-48,389,514 Size: 14,803 Coding Exon Count: 6 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr19:48,373,724-48,389,572)mRNA (may differ from genome)Protein (285 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
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HGNCMalacardsMGIOMIMPubMedReactome
UniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: ST2A1_HUMAN
DESCRIPTION: RecName: Full=Bile salt sulfotransferase; EC=2.8.2.14; AltName: Full=Dehydroepiandrosterone sulfotransferase; Short=DHEA-ST; AltName: Full=Hydroxysteroid Sulfotransferase; Short=HST; AltName: Full=ST2; AltName: Full=ST2A3; AltName: Full=Sulfotransferase 2A1; Short=ST2A1;
FUNCTION: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfonation of steroids and bile acids in the liver and adrenal glands.
CATALYTIC ACTIVITY: 3'-phosphoadenylyl sulfate + glycolithocholate = adenosine 3',5'-bisphosphate + glycolithocholate 3-sulfate.
CATALYTIC ACTIVITY: 3'-phosphoadenylyl sulfate + taurolithocholate = adenosine 3',5'-bisphosphate + taurolithocholate sulfate.
SUBUNIT: Homodimer.
INTERACTION: P40763:STAT3; NbExp=2; IntAct=EBI-3921363, EBI-518675;
SUBCELLULAR LOCATION: Cytoplasm.
TISSUE SPECIFICITY: Liver, adrenal and at lower level in the kidney. Is present in human fetus in higher level in the adrenal than the liver and the kidney.
PTM: The N-terminus is blocked.
MISCELLANEOUS: Estrogens present in maternal circulation is predominantly derived from fetal dehydroepiandosterone sulfate which is hydrolyzed and metabolized to estrogens in placenta.
SIMILARITY: Belongs to the sulfotransferase 1 family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: SULT2A1
Diseases sorted by gene-association score: sex differentiation disease (9), adrenal cortical adenoma (8), polycystic ovary syndrome (6), ovarian brenner tumor (5), cholangitis, primary sclerosing (4), gonadal disease (4)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 241.87 RPKM in Liver
Total median expression: 420.60 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -13.4058-0.231 Picture PostScript Text
3' UTR -280.50988-0.284 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000863 - Sulfotransferase_dom

Pfam Domains:
PF00685 - Sulfotransferase domain
PF13469 - Sulfotransferase family

SCOP Domains:
51905 - FAD/NAD(P)-binding domain
52540 - P-loop containing nucleoside triphosphate hydrolases

Protein Data Bank (PDB) 3-D Structure
MuPIT help
1EFH - X-ray MuPIT 1J99 - X-ray MuPIT 1OV4 - X-ray MuPIT 2QP3 - X-ray MuPIT 2QP4 - X-ray MuPIT 3F3Y - X-ray MuPIT


ModBase Predicted Comparative 3D Structure on Q06520
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologGenome BrowserNo ortholog
 Gene Details  Gene Details 
 Gene Sorter  Gene Sorter 
 RGD  WormBase 
    Protein Sequence 
    Alignment 

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004062 aryl sulfotransferase activity
GO:0004304 estrone sulfotransferase activity
GO:0005515 protein binding
GO:0008146 sulfotransferase activity
GO:0016740 transferase activity
GO:0047704 bile-salt sulfotransferase activity
GO:0050294 steroid sulfotransferase activity

Biological Process:
GO:0006068 ethanol catabolic process
GO:0006629 lipid metabolic process
GO:0008202 steroid metabolic process
GO:0016042 lipid catabolic process
GO:0019216 regulation of lipid metabolic process
GO:0030573 bile acid catabolic process
GO:0050427 3'-phosphoadenosine 5'-phosphosulfate metabolic process
GO:0051923 sulfation

Cellular Component:
GO:0005737 cytoplasm
GO:0005829 cytosol


-  Descriptions from all associated GenBank mRNAs
  S43861 - ST2=alcohol/hydroxysteroid sulfotransferase {clone II} [human, liver, mRNA, 1543 nt].
U08024 - Human clone A dehydroepiandrosterone sulfotransferase (STD) mRNA, complete cds.
JD126274 - Sequence 107298 from Patent EP1572962.
JD389074 - Sequence 370098 from Patent EP1572962.
JD457593 - Sequence 438617 from Patent EP1572962.
JD335483 - Sequence 316507 from Patent EP1572962.
JD310157 - Sequence 291181 from Patent EP1572962.
JD360920 - Sequence 341944 from Patent EP1572962.
JD384119 - Sequence 365143 from Patent EP1572962.
JD389073 - Sequence 370097 from Patent EP1572962.
JD440805 - Sequence 421829 from Patent EP1572962.
JD472577 - Sequence 453601 from Patent EP1572962.
JD257065 - Sequence 238089 from Patent EP1572962.
JD199625 - Sequence 180649 from Patent EP1572962.
JD112481 - Sequence 93505 from Patent EP1572962.
JD485370 - Sequence 466394 from Patent EP1572962.
JD220615 - Sequence 201639 from Patent EP1572962.
JD119019 - Sequence 100043 from Patent EP1572962.
AK289380 - Homo sapiens cDNA FLJ77905 complete cds, highly similar to Homo sapiens sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1 (SULT2A1), mRNA.
JD481349 - Sequence 462373 from Patent EP1572962.
JD047497 - Sequence 28521 from Patent EP1572962.
JD249806 - Sequence 230830 from Patent EP1572962.
JD148278 - Sequence 129302 from Patent EP1572962.
JD249807 - Sequence 230831 from Patent EP1572962.
JD288482 - Sequence 269506 from Patent EP1572962.
JD463791 - Sequence 444815 from Patent EP1572962.
JD500056 - Sequence 481080 from Patent EP1572962.
JD478550 - Sequence 459574 from Patent EP1572962.
JD489427 - Sequence 470451 from Patent EP1572962.
JD279555 - Sequence 260579 from Patent EP1572962.
JD037026 - Sequence 18050 from Patent EP1572962.
U08025 - Human clone G dehydroepiandrosterone sulfotransferase (STD) mRNA, complete cds.
L20000 - Human dehydroepiandrosterone sulfotransferase mRNA, complete cds.
X70222 - H.sapiens mRNA for dehydroepiandrosterone sulphotransferase.
BC020755 - Homo sapiens sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1, mRNA (cDNA clone MGC:22602 IMAGE:4733628), complete cds.
L02337 - Human sulfotransferase-related mRNA sequence.
S43859 - ST2=alcohol/hydroxysteroid sulfotransferase {clone I} [human, liver, mRNA, 1051 nt].
X84816 - H.sapiens mRNA for hydroxysteroid sulfotransferase.
JD295323 - Sequence 276347 from Patent EP1572962.
AK313415 - Homo sapiens cDNA, FLJ93953, highly similar to Homo sapiens sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA) -preferring, member 1 (SULT2A1), mRNA.
CU676700 - Synthetic construct Homo sapiens gateway clone IMAGE:100022233 5' read SULT2A1 mRNA.
DQ891165 - Synthetic construct clone IMAGE:100003795; FLH176696.01X; RZPDo839G04122D sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1 (SULT2A1) gene, encodes complete protein.
DQ894346 - Synthetic construct Homo sapiens clone IMAGE:100008806; FLH176695.01L; RZPDo839G04121D sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1 (SULT2A1) gene, encodes complete protein.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q06520 (Reactome details) participates in the following event(s):

R-HSA-176588 lithocholate + PAPS => lithocholate sulfate + PAP
R-HSA-176604 taurolithocholate + PAPS => taurolithocholate sulfate + PAP
R-HSA-176631 dehydroepiandrosterone (DHEA) + PAPS => DHEA sulfate + PAP
R-HSA-176585 3,5,3'-triiodothyronine + PAPS => 3,5,3'-triiodothyronine 4-sulfate + PAP
R-HSA-176664 estrone + PAPS => estrone 3-sulfate + PAP
R-HSA-176474 3,3'-diiodothyronine + PAPS => 3,3'-diiodothyronine 4-sulfate + PAP
R-HSA-1989781 PPARA activates gene expression
R-HSA-400206 Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
R-HSA-156584 Cytosolic sulfonation of small molecules
R-HSA-556833 Metabolism of lipids
R-HSA-156580 Phase II - Conjugation of compounds
R-HSA-1430728 Metabolism
R-HSA-211859 Biological oxidations

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000222002.1, ENST00000222002.2, ENST00000222002.3, HST, NM_003167, Q06520, ST2A1_HUMAN, STD, uc317ddf.1, uc317ddf.2
UCSC ID: ENST00000222002.4_7
RefSeq Accession: NM_003167.4
Protein: Q06520 (aka ST2A1_HUMAN or SUHA_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.