Human Gene SUGP2 (ENST00000452918.7_12) from GENCODE V47lift37

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Description: SURP and G-patch domain containing 2, transcript variant 8 (from RefSeq NR_147914.2)
Gencode Transcript: ENST00000452918.7_12
Gencode Gene: ENSG00000064607.17_14
Transcript (Including UTRs)
Position: hg19 chr19:19,101,702-19,144,326 Size: 42,625 Total Exon Count: 11 Strand: -
Coding Region
Position: hg19 chr19:19,105,175-19,141,880 Size: 36,706 Coding Exon Count: 9

Page Index	Sequence and Links	UniProtKB Comments	Primers	CTD	Gene Alleles
RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species	GO Annotations
mRNA Descriptions	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr19:19,101,702-19,144,326)			mRNA (may differ from genome)		Protein (1082 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	MGI	OMIM	PubMed	UniProtKB	Wikipedia
BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: SUGP2_HUMAN DESCRIPTION: RecName: Full=SURP and G-patch domain-containing protein 2; AltName: Full=Arginine/serine-rich-splicing factor 14; AltName: Full=Splicing factor, arginine/serine-rich 14; FUNCTION: May play a role in mRNA splicing (Potential). SUBCELLULAR LOCATION: Nucleus (Potential). TISSUE SPECIFICITY: Detected in adult testis, and in fetal brain and kidney. PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. SIMILARITY: Contains 1 G-patch domain. SIMILARITY: Contains 2 SURP motif repeats. SEQUENCE CAUTION: Sequence=AAC06129.1; Type=Erroneous gene model prediction; Sequence=AAH20586.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAA20820.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D001564 Benzo(a)pyrene C016403 2,4-dinitrotoluene C023514 2,6-dinitrotoluene C009505 4,4'-diaminodiphenylmethane C103505 AM 251 D016604 Aflatoxin B1 D019327 Copper Sulfate D004997 Ethinyl Estradiol D006710 Homocysteine D008727 Methotrexate more ... click here to view the complete list

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 71.70 RPKM in Testis Total median expression: 1277.13 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-51.40	92	-0.559	Picture	PostScript	Text
3' UTR	-987.30	2848	-0.347	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR000467 - G_patch_dom
IPR000061 - Surp

Pfam Domains:
PF01585 - G-patch domain
PF01805 - Surp module

SCOP Domains:
109905 - Surp module (SWAP domain)

Protein Data Bank (PDB) 3-D Structure
MuPIT help

1X4P - NMR MuPIT

ModBase Predicted Comparative 3D Structure on Q8IX01


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details	Gene Details
Gene Sorter	Gene Sorter
	RGD

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0003676 nucleic acid binding GO:0003723 RNA binding Biological Process: GO:0006396 RNA processing GO:0006397 mRNA processing GO:0008380 RNA splicing Cellular Component: GO:0005634 nucleus GO:0005654 nucleoplasm GO:0016604 nuclear body

Descriptions from all associated GenBank mRNAs


	AK291275 - Homo sapiens cDNA FLJ76836 complete cds, highly similar to Homo sapiens splicing factor, arginine/serine-rich 14 (SFRS14), transcript variant 2, mRNA. BC020586 - Homo sapiens splicing factor, arginine/serine-rich 14, mRNA (cDNA clone MGC:22011 IMAGE:4400185), complete cds. AL832488 - Homo sapiens mRNA; cDNA DKFZp686C1922 (from clone DKFZp686C1922). AF518874 - Homo sapiens arginine/serine-rich 14 splicing factor (SFRS14) mRNA, complete cds. AK074842 - Homo sapiens cDNA FLJ90361 fis, clone NT2RP2003931. AB002363 - Homo sapiens KIAA0365 mRNA for KIAA0365 protein. BX647813 - Homo sapiens mRNA; cDNA DKFZp686E0151 (from clone DKFZp686E0151). AL832587 - Homo sapiens mRNA; cDNA DKFZp451K1016 (from clone DKFZp451K1016). AB384468 - Synthetic construct DNA, clone: pF1KA0365, Homo sapiens SFRS14 gene for splicing factor, arginine/serine-rich 14, complete cds, without stop codon, in Flexi system. AK299860 - Homo sapiens cDNA FLJ55365 complete cds, highly similar to splicing factor, arginine/serine-rich14. KJ902065 - Synthetic construct Homo sapiens clone ccsbBroadEn_11459 SUGP2 gene, encodes complete protein. AK025508 - Homo sapiens cDNA: FLJ21855 fis, clone HEP02277. CR627095 - Homo sapiens mRNA; cDNA DKFZp779L2418 (from clone DKFZp779L2418). JD276585 - Sequence 257609 from Patent EP1572962. JD469328 - Sequence 450352 from Patent EP1572962. JD440747 - Sequence 421771 from Patent EP1572962. JD421665 - Sequence 402689 from Patent EP1572962. JD381002 - Sequence 362026 from Patent EP1572962. JD076390 - Sequence 57414 from Patent EP1572962. JD045031 - Sequence 26055 from Patent EP1572962. BX647933 - Homo sapiens mRNA; cDNA DKFZp686M2322 (from clone DKFZp686M2322). JD020930 - Sequence 1954 from Patent EP1572962. JD030170 - Sequence 11194 from Patent EP1572962. JD140166 - Sequence 121190 from Patent EP1572962.

Other Names for This Gene


	Alternate Gene Symbols: C9JI71, ENST00000452918.1, ENST00000452918.2, ENST00000452918.3, ENST00000452918.4, ENST00000452918.5, ENST00000452918.6, KIAA0365, NR_147914, O15071, O60369, Q5JPH7, Q8IX01, Q8WUF7, SFRS14, SUGP2_HUMAN, uc320udx.1, uc320udx.2 UCSC ID: ENST00000452918.7_12 RefSeq Accession: NM_001017392.5 Protein: Q8IX01 (aka SUGP2_HUMAN)

Gene Model Information


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Methods, Credits, and Use Restrictions


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