ID:STX4_HUMAN DESCRIPTION: RecName: Full=Syntaxin-4; AltName: Full=Renal carcinoma antigen NY-REN-31; FUNCTION: Plasma membrane t-SNARE that mediates docking of transport vesicles. Necessary for the translocation of SLC2A4 from intracellular vesicles to the plasma membrane. Together with STXB3 and VAMP2, may also play a role in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes (By similarity). May also play a role in docking of synaptic vesicles at presynaptic active zones. SUBUNIT: Component of the SNARE complex composed of STX4, SNAP23 and VAMP7 that interacts with SYT7 during lysosomal exocytosis. Found in a complex with VAMP8 and SNAP23. Detected in a complex with SNAP23 and STXBP4. Interacts with VAMP2. Interacts with SNAP23 and SNAPIN. Interacts with LLGL1. Interacts (via C- terminus) with CENPF. Interacts with DOC2B. Interacts with STXBP6. Interacts with STXBP3; excludes interaction with DOC2B and SNAP25. Interacts with STXBP4; excludes interaction with VAMP2 (By similarity). INTERACTION: P54920:NAPA; NbExp=2; IntAct=EBI-744942, EBI-749652; SUBCELLULAR LOCATION: Cell membrane; Single-pass type IV membrane protein (Potential). TISSUE SPECIFICITY: Expressed in neutrophils and neutrophil- differentiated HL-60 cells. Expression in neutrophils increases with differentiation. SIMILARITY: Belongs to the syntaxin family. SIMILARITY: Contains 1 t-SNARE coiled-coil homology domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q12846
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006836 neurotransmitter transport GO:0006886 intracellular protein transport GO:0008284 positive regulation of cell proliferation GO:0016192 vesicle-mediated transport GO:0017157 regulation of exocytosis GO:0019221 cytokine-mediated signaling pathway GO:0030335 positive regulation of cell migration GO:0031629 synaptic vesicle fusion to presynaptic active zone membrane GO:0033194 response to hydroperoxide GO:0035493 SNARE complex assembly GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus GO:0043085 positive regulation of catalytic activity GO:0043311 positive regulation of eosinophil degranulation GO:0045785 positive regulation of cell adhesion GO:0048278 vesicle docking GO:0048284 organelle fusion GO:0050921 positive regulation of chemotaxis GO:0051024 positive regulation of immunoglobulin secretion GO:0060291 long-term synaptic potentiation GO:0071346 cellular response to interferon-gamma GO:1902041 regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1903078 positive regulation of protein localization to plasma membrane GO:1990668 vesicle fusion with endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane GO:2000010 positive regulation of protein localization to cell surface
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
