Human Gene STOML1 (ENST00000541638.6_11) from GENCODE V47lift37
  Description: stomatin like 1, transcript variant 1 (from RefSeq NM_004809.5)
Gencode Transcript: ENST00000541638.6_11
Gencode Gene: ENSG00000067221.14_16
Transcript (Including UTRs)
   Position: hg19 chr15:74,271,267-74,284,636 Size: 13,370 Total Exon Count: 7 Strand: -
Coding Region
   Position: hg19 chr15:74,276,278-74,284,564 Size: 8,287 Coding Exon Count: 7 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr15:74,271,267-74,284,636)mRNA (may differ from genome)Protein (398 aa)
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-  Comments and Description Text from UniProtKB
  ID: STML1_HUMAN
DESCRIPTION: RecName: Full=Stomatin-like protein 1; Short=SLP-1; AltName: Full=EPB72-like protein 1; AltName: Full=Protein unc-24 homolog; AltName: Full=Stomatin-related protein; Short=STORP;
SUBCELLULAR LOCATION: Membrane; Single-pass type III membrane protein (Potential).
TISSUE SPECIFICITY: Ubiquitously expressed at low levels. Expression is highest in brain.
SIMILARITY: Belongs to the band 7/mec-2 family.
SIMILARITY: Contains 1 SCP2 domain.
SEQUENCE CAUTION: Sequence=AAD42031.1; Type=Frameshift; Positions=201, 210; Sequence=CAA76271.1; Type=Frameshift; Positions=230, 233, 263, 292, 300;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 24.93 RPKM in Brain - Frontal Cortex (BA9)
Total median expression: 419.44 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -41.7072-0.579 Picture PostScript Text
3' UTR -1952.805011-0.390 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001107 - Band_7
IPR003033 - SCP2_sterol-bd_dom
IPR001972 - Stomatin

Pfam Domains:
PF01145 - SPFH domain / Band 7 family
PF02036 - SCP-2 sterol transfer family

SCOP Domains:
55718 - SCP-like
117892 - Band 7/SPFH domain

ModBase Predicted Comparative 3D Structure on Q9UBI4
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003674 molecular_function
GO:0005515 protein binding

Biological Process:
GO:0006869 lipid transport
GO:0008150 biological_process

Cellular Component:
GO:0005575 cellular_component
GO:0005768 endosome
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0031410 cytoplasmic vesicle
GO:0031902 late endosome membrane
GO:0045121 membrane raft


-  Descriptions from all associated GenBank mRNAs
  JD269695 - Sequence 250719 from Patent EP1572962.
JD354064 - Sequence 335088 from Patent EP1572962.
JD378024 - Sequence 359048 from Patent EP1572962.
JD249576 - Sequence 230600 from Patent EP1572962.
JD085118 - Sequence 66142 from Patent EP1572962.
JD447688 - Sequence 428712 from Patent EP1572962.
JD267403 - Sequence 248427 from Patent EP1572962.
JD228964 - Sequence 209988 from Patent EP1572962.
JD143854 - Sequence 124878 from Patent EP1572962.
JD332020 - Sequence 313044 from Patent EP1572962.
JD175728 - Sequence 156752 from Patent EP1572962.
JD531480 - Sequence 512504 from Patent EP1572962.
JD447687 - Sequence 428711 from Patent EP1572962.
JD447284 - Sequence 428308 from Patent EP1572962.
JD224618 - Sequence 205642 from Patent EP1572962.
JD411965 - Sequence 392989 from Patent EP1572962.
JD143493 - Sequence 124517 from Patent EP1572962.
JD431818 - Sequence 412842 from Patent EP1572962.
JD494550 - Sequence 475574 from Patent EP1572962.
AK302051 - Homo sapiens cDNA FLJ54946 complete cds, highly similar to Stomatin-like protein 1.
AL109664 - Homo sapiens mRNA full length insert cDNA clone EUROIMAGE 23681.
AF074953 - Homo sapiens stomatin-like protein UNC24 (UNC24) mRNA, partial cds.
AL109665 - Homo sapiens mRNA full length insert cDNA clone EUROIMAGE 25795.
Y16522 - Homo sapiens mRNA for hSLP-1 protein.
BC034379 - Homo sapiens stomatin (EPB72)-like 1, mRNA (cDNA clone MGC:34477 IMAGE:5185908), complete cds.
BC065249 - Homo sapiens stomatin (EPB72)-like 1, mRNA (cDNA clone MGC:74688 IMAGE:6059393), complete cds.
AF111800 - Homo sapiens MSTP019 (MST019) mRNA, complete cds.
AF156557 - Homo sapiens stomatin related protein mRNA, complete cds.
AK093689 - Homo sapiens cDNA FLJ36370 fis, clone THYMU2008036, highly similar to Homo sapiens stomatin-like protein UNC24 (UNC24) mRNA.
AK075244 - Homo sapiens cDNA FLJ90763 fis, clone THYRO1000400, highly similar to Stomatin-like protein 1.
JD108583 - Sequence 89607 from Patent EP1572962.
JD072477 - Sequence 53501 from Patent EP1572962.
JD555103 - Sequence 536127 from Patent EP1572962.
JD231265 - Sequence 212289 from Patent EP1572962.
JD164177 - Sequence 145201 from Patent EP1572962.
JD170319 - Sequence 151343 from Patent EP1572962.
JD278854 - Sequence 259878 from Patent EP1572962.
JD356102 - Sequence 337126 from Patent EP1572962.
JD092624 - Sequence 73648 from Patent EP1572962.
JD538242 - Sequence 519266 from Patent EP1572962.
JD276109 - Sequence 257133 from Patent EP1572962.
JD470450 - Sequence 451474 from Patent EP1572962.
JD540294 - Sequence 521318 from Patent EP1572962.
JD399648 - Sequence 380672 from Patent EP1572962.
JD192673 - Sequence 173697 from Patent EP1572962.
JD442289 - Sequence 423313 from Patent EP1572962.
JD339606 - Sequence 320630 from Patent EP1572962.
JD229456 - Sequence 210480 from Patent EP1572962.
JD386369 - Sequence 367393 from Patent EP1572962.
JD188730 - Sequence 169754 from Patent EP1572962.
JD122676 - Sequence 103700 from Patent EP1572962.
AK300799 - Homo sapiens cDNA FLJ55249 complete cds, highly similar to Stomatin-like protein 1.
JD178405 - Sequence 159429 from Patent EP1572962.
AK222665 - Homo sapiens mRNA for stomatin (EPB72)-like 1 variant, clone: CBR00775.
CR542089 - Homo sapiens full open reading frame cDNA clone RZPDo834C0437D for gene STOML1, stomatin (EPB72)-like 1; complete cds, incl. stopcodon.
DQ064605 - Homo sapiens stomatin-like 1 mRNA, complete cds, alternatively spliced.
AB587381 - Synthetic construct DNA, clone: pF1KB5185, Homo sapiens STOML1 gene for stomatin (EPB72)-like 1, without stop codon, in Flexi system.
AK091531 - Homo sapiens cDNA FLJ34212 fis, clone FCBBF3021501, weakly similar to Homo sapiens stomatin-like protein UNC24 (UNC24) mRNA.

-  Other Names for This Gene
  Alternate Gene Symbols: B3KQN0, B4DUU5, B4DXM9, E7ESC0, ENST00000541638.1, ENST00000541638.2, ENST00000541638.3, ENST00000541638.4, ENST00000541638.5, H3BRP3, MSTP019, NM_004809, O95675, Q4PNR4, Q6FGL8, Q8WYI7, Q9UBI4, Q9UMB9, Q9UMC0, Q9Y6H9, SLP1, STML1_HUMAN, uc324tec.1, uc324tec.2, UNC24
UCSC ID: ENST00000541638.6_11
RefSeq Accession: NM_004809.5
Protein: Q9UBI4 (aka STML1_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.