ID:STK39_HUMAN DESCRIPTION: RecName: Full=STE20/SPS1-related proline-alanine-rich protein kinase; Short=Ste-20-related kinase; EC=2.7.11.1; AltName: Full=DCHT; AltName: Full=Serine/threonine-protein kinase 39; FUNCTION: May act as a mediator of stress-activated signals. CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein. SUBUNIT: The phosphorylated form forms a complex with WNK2 (By similarity). SUBCELLULAR LOCATION: Cytoplasm (Probable). Nucleus (Probable). Note=Nucleus when caspase-cleaved (Probable). TISSUE SPECIFICITY: Predominantly expressed in brain and pancreas followed by heart, lung, kidney, skeletal muscle, liver, placenta and testis. DOMAIN: PAPA box (proline-alanine repeats) may target the kinase to a specific subcellular location by facilitating interaction with intracellular proteins such as actin or actin-like proteins. PTM: Phosphorylated at Ser-309 by PRKCQ. SIMILARITY: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. SIMILARITY: Contains 1 protein kinase domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF00069 - Protein kinase domain PF03109 - ABC1 atypical kinase-like domain PF07714 - Protein tyrosine and serine/threonine kinase PF12202 - Oxidative-stress-responsive kinase 1 C-terminal domain
SCOP Domains: 56112 - Protein kinase-like (PK-like)
ModBase Predicted Comparative 3D Structure on Q9UEW8
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0000187 activation of MAPK activity GO:0001933 negative regulation of protein phosphorylation GO:0006468 protein phosphorylation GO:0007346 regulation of mitotic cell cycle GO:0008217 regulation of blood pressure GO:0016310 phosphorylation GO:0018105 peptidyl-serine phosphorylation GO:0018107 peptidyl-threonine phosphorylation GO:0023014 signal transduction by protein phosphorylation GO:0023016 signal transduction by trans-phosphorylation GO:0031098 stress-activated protein kinase signaling cascade GO:0032147 activation of protein kinase activity GO:0032414 positive regulation of ion transmembrane transporter activity GO:0035556 intracellular signal transduction GO:0036438 maintenance of lens transparency GO:0042981 regulation of apoptotic process GO:0043268 positive regulation of potassium ion transport GO:0046777 protein autophosphorylation GO:0050727 regulation of inflammatory response GO:0050801 ion homeostasis GO:0071476 cellular hypotonic response GO:0090188 negative regulation of pancreatic juice secretion GO:1901017 negative regulation of potassium ion transmembrane transporter activity GO:1901380 negative regulation of potassium ion transmembrane transport GO:1905408 negative regulation of creatine transmembrane transporter activity GO:2000650 negative regulation of sodium ion transmembrane transporter activity
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
