ID:STK35_HUMAN DESCRIPTION: RecName: Full=Serine/threonine-protein kinase 35; EC=2.7.11.1; AltName: Full=CLP-36-interacting kinase 1; Short=CLIK-1; AltName: Full=PDLIM1-interacting kinase 1; AltName: Full=Serine/threonine-protein kinase 35 L1; CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein. SUBUNIT: Interacts with PDLIM1/CLP-36. SUBCELLULAR LOCATION: Nucleus. Nucleus, nucleolus. Cytoplasm. Note=When associated with PDLIM1, it is mostly found in cytoplasm, localized to actin stress fibers (PubMed:11973348). However, PubMed:19756140 detected STK35 only in the nucleus, and the presence of PDLIM1 had no influence on its location. TISSUE SPECIFICITY: Expressed in testis. PTM: Autophosphorylated. MISCELLANEOUS: Association with PDLIM1 is controversial (PubMed:11973348). SIMILARITY: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. SIMILARITY: Contains 1 protein kinase domain. SEQUENCE CAUTION: Sequence=AAI40884.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAI40885.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAG37270.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=CAI15590.1; Type=Erroneous gene model prediction;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF00069 - Protein kinase domain PF07714 - Protein tyrosine and serine/threonine kinase
SCOP Domains: 56112 - Protein kinase-like (PK-like)
ModBase Predicted Comparative 3D Structure on Q8TDR2
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
