Human Gene STC2 (ENST00000265087.9_7) from GENCODE V47lift37

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Description: stanniocalcin 2 (from RefSeq NM_003714.3)
Gencode Transcript: ENST00000265087.9_7
Gencode Gene: ENSG00000113739.11_11
Transcript (Including UTRs)
Position: hg19 chr5:172,741,726-172,755,417 Size: 13,692 Total Exon Count: 4 Strand: -
Coding Region
Position: hg19 chr5:172,744,850-172,755,196 Size: 10,347 Coding Exon Count: 4

Page Index	Sequence and Links	Primers	CTD	Gene Alleles	RNA-Seq Expression
Microarray Expression	RNA Structure	Protein Structure	Other Species	GO Annotations	mRNA Descriptions
Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr5:172,741,726-172,755,417)			mRNA (may differ from genome)		Protein (302 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	MGI	OMIM	PubMed	UniProtKB	Wikipedia
BioGrid CRISPR DB

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D013749 Tetrachlorodibenzodioxin D016572 Cyclosporine D010100 Oxygen C057693 troglitazone C032668 1-nitropyrene C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester C472791 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid D015124 8-Bromo Cyclic Adenosine Monophosphate D016604 Aflatoxin B1 D000643 Ammonium Chloride more ... click here to view the complete list

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 59.72 RPKM in Cells - Cultured fibroblasts Total median expression: 166.48 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-64.80	221	-0.293	Picture	PostScript	Text
3' UTR	-992.00	3124	-0.318	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR004978 - Stanniocalcin

Pfam Domains:
PF03298 - Stanniocalcin family

ModBase Predicted Comparative 3D Structure on Q6FHC9


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details	Gene Details
Gene Sorter	Gene Sorter
	RGD	Ensembl

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0005179 hormone activity Biological Process: GO:0006874 cellular calcium ion homeostasis GO:0006979 response to oxidative stress GO:0007566 embryo implantation GO:0010469 regulation of receptor activity GO:0030968 endoplasmic reticulum unfolded protein response GO:0033280 response to vitamin D GO:0034976 response to endoplasmic reticulum stress GO:0040015 negative regulation of multicellular organism growth GO:0043434 response to peptide hormone GO:0046697 decidualization GO:0055074 calcium ion homeostasis GO:0071456 cellular response to hypoxia GO:2001256 regulation of store-operated calcium entry Cellular Component: GO:0005576 extracellular region GO:0005783 endoplasmic reticulum GO:0005794 Golgi apparatus

Descriptions from all associated GenBank mRNAs


	AF098462 - Homo sapiens stanniocalcin-related protein mRNA, complete cds. AK095862 - Homo sapiens cDNA FLJ38543 fis, clone HCHON2001546, highly similar to STANNIOCALCIN 2 PRECURSOR. AK027663 - Homo sapiens cDNA FLJ14757 fis, clone NT2RP3003242, highly similar to Stanniocalcin-2 precursor. AK095891 - Homo sapiens cDNA FLJ38572 fis, clone HCHON2006786, highly similar to Stanniocalcin-2 precursor. BC006352 - Homo sapiens stanniocalcin 2, mRNA (cDNA clone MGC:12863 IMAGE:4120602), complete cds. BC013958 - Homo sapiens stanniocalcin 2, mRNA (cDNA clone MGC:3759 IMAGE:3010678), complete cds. AF055460 - Homo sapiens stanniocalcin-2 (STC-2) mRNA, complete cds. BC000658 - Homo sapiens stanniocalcin 2, mRNA (cDNA clone MGC:1881 IMAGE:3347440), complete cds. AB012664 - Homo sapiens hSTC2 mRNA for human second stanniocalcin, complete cds. AK027390 - Homo sapiens cDNA FLJ14484 fis, clone MAMMA1002485, highly similar to Stanniocalcin-2 precursor. AK075406 - Homo sapiens cDNA PSEC0097 fis, clone NT2RP2002139, highly similar to Stanniocalcin-2 precursor. EU832632 - Synthetic construct Homo sapiens clone HAIB:100067661; DKFZo008D0331 stanniocalcin 2 protein (STC2) gene, encodes complete protein. EU832707 - Synthetic construct Homo sapiens clone HAIB:100067736; DKFZo004D0332 stanniocalcin 2 protein (STC2) gene, encodes complete protein. AF031036 - Homo sapiens stanniocalcin (STC2) mRNA, complete cds. KJ892575 - Synthetic construct Homo sapiens clone ccsbBroadEn_01969 STC2 gene, encodes complete protein. BT019591 - Homo sapiens stanniocalcin 2 mRNA, complete cds. CR541825 - Homo sapiens full open reading frame cDNA clone RZPDo834B0532D for gene STC2, stanniocalcin 2; complete cds, without stopcodon. CU674324 - Synthetic construct Homo sapiens gateway clone IMAGE:100020675 5' read STC2 mRNA. JD302179 - Sequence 283203 from Patent EP1572962. JD369388 - Sequence 350412 from Patent EP1572962. JD203092 - Sequence 184116 from Patent EP1572962. JD326271 - Sequence 307295 from Patent EP1572962. JD310881 - Sequence 291905 from Patent EP1572962. JD202628 - Sequence 183652 from Patent EP1572962. JD509399 - Sequence 490423 from Patent EP1572962. JD429647 - Sequence 410671 from Patent EP1572962. JD134974 - Sequence 115998 from Patent EP1572962. JD236062 - Sequence 217086 from Patent EP1572962. JD540382 - Sequence 521406 from Patent EP1572962. JD232415 - Sequence 213439 from Patent EP1572962. JD154169 - Sequence 135193 from Patent EP1572962. JD078031 - Sequence 59055 from Patent EP1572962. JD452652 - Sequence 433676 from Patent EP1572962. JD158431 - Sequence 139455 from Patent EP1572962. JD427179 - Sequence 408203 from Patent EP1572962. JD051809 - Sequence 32833 from Patent EP1572962. JD209052 - Sequence 190076 from Patent EP1572962. JD190944 - Sequence 171968 from Patent EP1572962. JD494926 - Sequence 475950 from Patent EP1572962. JD498774 - Sequence 479798 from Patent EP1572962. JD058105 - Sequence 39129 from Patent EP1572962. JD219730 - Sequence 200754 from Patent EP1572962. JD429708 - Sequence 410732 from Patent EP1572962. JD049095 - Sequence 30119 from Patent EP1572962. JD471407 - Sequence 452431 from Patent EP1572962. JD043804 - Sequence 24828 from Patent EP1572962. JD468558 - Sequence 449582 from Patent EP1572962. JD498237 - Sequence 479261 from Patent EP1572962. JD468620 - Sequence 449644 from Patent EP1572962. JD311200 - Sequence 292224 from Patent EP1572962. JD498236 - Sequence 479260 from Patent EP1572962. JD073752 - Sequence 54776 from Patent EP1572962. JD178393 - Sequence 159417 from Patent EP1572962.

Other Names for This Gene


	Alternate Gene Symbols: ENST00000265087.1, ENST00000265087.2, ENST00000265087.3, ENST00000265087.4, ENST00000265087.5, ENST00000265087.6, ENST00000265087.7, ENST00000265087.8, hCG_40281 , NM_003714, Q6FHC9, Q6FHC9_HUMAN, STC2 , uc317hyl.1, uc317hyl.2 UCSC ID: ENST00000265087.9_7 RefSeq Accession: NM_003714.3 Protein: Q6FHC9

Gene Model Information


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Methods, Credits, and Use Restrictions


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