ID:STA5B_HUMAN DESCRIPTION: RecName: Full=Signal transducer and activator of transcription 5B; FUNCTION: Carries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. Binds to the GAS element and activates PRL-induced transcription. SUBUNIT: Forms a homodimer or a heterodimer with a related family member. Binds NR3C1 (By similarity). Interacts with NCOA1, NMI and SOCS7. Interacts (via SH2 domain) with INSR. INTERACTION: Q96EY1:DNAJA3; NbExp=2; IntAct=EBI-1186119, EBI-356767; Q13287:NMI; NbExp=7; IntAct=EBI-1186119, EBI-372942; SUBCELLULAR LOCATION: Cytoplasm (By similarity). Nucleus (By similarity). Note=Translocated into the nucleus in response to phosphorylation (By similarity). PTM: Tyrosine phosphorylated in response to signaling via activated KIT, resulting in translocation to the nucleus. Tyrosine phosphorylated in response to signaling via activated FLT3; wild- type FLT3 results in much weaker phosphorylation than constitutively activated mutant FLT3. Alternatively, can be phosphorylated by JAK2. Phosphoryation at Tyr-699 by PTK6 or HCK leads to an increase of its transcriptional activity. DISEASE: Defects in STAT5B are the cause of growth hormone insensitivity with immunodeficiency (GHII) [MIM:245590]. A disease characterized by short stature, growth hormone deficiency in the presence of normal to elevated circulating concentrations of growth hormone, resistance to hexogeneous growth hormone therapy, and recurrent infections. SIMILARITY: Belongs to the transcription factor STAT family. SIMILARITY: Contains 1 SH2 domain. WEB RESOURCE: Name=STAT5Bbase; Note=STAT5B mutation db; URL="http://bioinf.uta.fi/STAT5Bbase/"; WEB RESOURCE: Name=Wikipedia; Note=STAT5 entry; URL="http://en.wikipedia.org/wiki/STAT5";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P51692
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0003677 DNA binding GO:0003682 chromatin binding GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0004713 protein tyrosine kinase activity GO:0004871 signal transducer activity GO:0005515 protein binding GO:0035259 glucocorticoid receptor binding GO:0046983 protein dimerization activity
Biological Process: GO:0000255 allantoin metabolic process GO:0001553 luteinization GO:0001779 natural killer cell differentiation GO:0006101 citrate metabolic process GO:0006103 2-oxoglutarate metabolic process GO:0006105 succinate metabolic process GO:0006107 oxaloacetate metabolic process GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006357 regulation of transcription from RNA polymerase II promoter GO:0006366 transcription from RNA polymerase II promoter GO:0006549 isoleucine metabolic process GO:0006573 valine metabolic process GO:0006600 creatine metabolic process GO:0006631 fatty acid metabolic process GO:0007165 signal transduction GO:0007259 JAK-STAT cascade GO:0007548 sex differentiation GO:0007565 female pregnancy GO:0007595 lactation GO:0008284 positive regulation of cell proliferation GO:0018108 peptidyl-tyrosine phosphorylation GO:0019218 regulation of steroid metabolic process GO:0019221 cytokine-mediated signaling pathway GO:0019530 taurine metabolic process GO:0019915 lipid storage GO:0030155 regulation of cell adhesion GO:0030856 regulation of epithelial cell differentiation GO:0032355 response to estradiol GO:0032819 positive regulation of natural killer cell proliferation GO:0032825 positive regulation of natural killer cell differentiation GO:0032870 cellular response to hormone stimulus GO:0033077 T cell differentiation in thymus GO:0035723 interleukin-15-mediated signaling pathway GO:0038110 interleukin-2-mediated signaling pathway GO:0038111 interleukin-7-mediated signaling pathway GO:0040014 regulation of multicellular organism growth GO:0040018 positive regulation of multicellular organism growth GO:0042104 positive regulation of activated T cell proliferation GO:0042448 progesterone metabolic process GO:0043029 T cell homeostasis GO:0043066 negative regulation of apoptotic process GO:0045086 positive regulation of interleukin-2 biosynthetic process GO:0045579 positive regulation of B cell differentiation GO:0045588 positive regulation of gamma-delta T cell differentiation GO:0045621 positive regulation of lymphocyte differentiation GO:0045647 negative regulation of erythrocyte differentiation GO:0045648 positive regulation of erythrocyte differentiation GO:0045931 positive regulation of mitotic cell cycle GO:0045944 positive regulation of transcription from RNA polymerase II promoter GO:0045954 positive regulation of natural killer cell mediated cytotoxicity GO:0046449 creatinine metabolic process GO:0046543 development of secondary female sexual characteristics GO:0046544 development of secondary male sexual characteristics GO:0048541 Peyer's patch development GO:0050729 positive regulation of inflammatory response GO:0060397 JAK-STAT cascade involved in growth hormone signaling pathway GO:0070669 response to interleukin-2 GO:0070670 response to interleukin-4 GO:0070672 response to interleukin-15 GO:0071363 cellular response to growth factor stimulus GO:0071364 cellular response to epidermal growth factor stimulus GO:0097531 mast cell migration
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
