Human Gene SRSF8 (ENST00000587424.3_4) from GENCODE V47lift37

JavaScript is disabled in your web browser

You must have JavaScript enabled in your web browser to use the Genome Browser

Description: serine and arginine rich splicing factor 8, transcript variant 3 (from RefSeq NR_169861.1)
Gencode Transcript: ENST00000587424.3_4
Gencode Gene: ENSG00000263465.5_8
Transcript (Including UTRs)
Position: hg19 chr11:94,800,083-94,804,388 Size: 4,306 Total Exon Count: 2 Strand: +
Coding Region
Position: hg19 chr11:94,800,391-94,801,238 Size: 848 Coding Exon Count: 2

Page Index	Sequence and Links	UniProtKB Comments	Primers	CTD	Gene Alleles
Microarray Expression	RNA Structure	Protein Structure	Other Species	GO Annotations	mRNA Descriptions
Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr11:94,800,083-94,804,388)			mRNA (may differ from genome)		Protein (281 aa)
Gene Sorter	Genome Browser	Other Species FASTA	Gene interactions	Table Schema	AlphaFold
Ensembl	ExonPrimer	GeneCards	HGNC	MGI	PubMed
UniProtKB

Comments and Description Text from UniProtKB


	ID: SRSF8_HUMAN DESCRIPTION: RecName: Full=Serine/arginine-rich splicing factor 8; AltName: Full=Pre-mRNA-splicing factor SRP46; Short=Splicing factor SRp46; AltName: Full=Splicing factor, arginine/serine-rich 2B; FUNCTION: Involved in pre-mRNA alternative splicing. SUBCELLULAR LOCATION: Nucleus. TISSUE SPECIFICITY: Strongly expressed in pancreas, spleen and prostate. Weakly expressed in lung, liver and thymus. SIMILARITY: Belongs to the splicing factor SR family. SIMILARITY: Contains 1 RRM (RNA recognition motif) domain.

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene C016403 2,4-dinitrotoluene D000082 Acetaminophen D019327 Copper Sulfate D005557 Formaldehyde D011794 Quercetin D024483 Vitamin K 3

Common Gene Haplotype Alleles


	Press "+" in the title bar above to open this section.

Microarray Expression Data


	Press "+" in the title bar above to open this section.

mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-132.30	308	-0.430	Picture	PostScript	Text
3' UTR	-809.20	3150	-0.257	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR012677 - Nucleotide-bd_a/b_plait
IPR000504 - RRM_dom

Pfam Domains:
PF00076 - RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)

SCOP Domains:
54928 - RNA-binding domain, RBD

Protein Data Bank (PDB) 3-D Structure
MuPIT help

2DNM - NMR MuPIT

ModBase Predicted Comparative 3D Structure on Q9BRL6


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details	Gene Details
Gene Sorter	Gene Sorter
	RGD

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0003676 nucleic acid binding GO:0003723 RNA binding GO:0005515 protein binding Biological Process: GO:0006397 mRNA processing GO:0008380 RNA splicing Cellular Component: GO:0005634 nucleus GO:0005829 cytosol GO:0016607 nuclear speck

Descriptions from all associated GenBank mRNAs


	KJ902178 - Synthetic construct Homo sapiens clone ccsbBroadEn_11572 SRSF8 gene, encodes complete protein. AK309776 - Homo sapiens cDNA, FLJ99817. AK312514 - Homo sapiens cDNA, FLJ92879, Homo sapiens Splicing factor, arginine/serine-rich, 46kD (SRP46),mRNA. AK023379 - Homo sapiens cDNA FLJ13317 fis, clone OVARC1001577, highly similar to Homo sapiens Splicing factor, arginine/serine-rich, 46 kD (SRP46), mRNA. BC057783 - Homo sapiens splicing factor, arginine/serine-rich 2B, mRNA (cDNA clone MGC:71595 IMAGE:5285882), complete cds. AF031166 - Homo sapiens SRp46 splicing factor (SRP46) mRNA, partial cds. JD090138 - Sequence 71162 from Patent EP1572962. JD067183 - Sequence 48207 from Patent EP1572962. JD303106 - Sequence 284130 from Patent EP1572962. JD244981 - Sequence 226005 from Patent EP1572962. JD502129 - Sequence 483153 from Patent EP1572962. JD508601 - Sequence 489625 from Patent EP1572962. AJ270685 - Homo sapiens partial unknown mRNA from drug-resistant melanoma cells, 3'UTR, clone DSM-1. JD199351 - Sequence 180375 from Patent EP1572962. JD164879 - Sequence 145903 from Patent EP1572962. JD511370 - Sequence 492394 from Patent EP1572962. JD181732 - Sequence 162756 from Patent EP1572962. JD110638 - Sequence 91662 from Patent EP1572962. JD556831 - Sequence 537855 from Patent EP1572962. JD376121 - Sequence 357145 from Patent EP1572962. JD497883 - Sequence 478907 from Patent EP1572962. JD536209 - Sequence 517233 from Patent EP1572962. JD421887 - Sequence 402911 from Patent EP1572962. JD421886 - Sequence 402910 from Patent EP1572962. JD291728 - Sequence 272752 from Patent EP1572962. JD533687 - Sequence 514711 from Patent EP1572962. JD446343 - Sequence 427367 from Patent EP1572962.

Other Names for This Gene


	Alternate Gene Symbols: B2R6B8, ENST00000587424.1, ENST00000587424.2, NR_169861, Q6PF01, Q96TA3, Q9BRL6, SFRS2B, SRP46, SRSF8_HUMAN, uc326rhb.1, uc326rhb.2 UCSC ID: ENST00000587424.3_4 RefSeq Accession: NM_000014.6 Protein: Q9BRL6 (aka SRSF8_HUMAN)

Gene Model Information


	Click here for a detailed description of the fields of the table above.

Methods, Credits, and Use Restrictions


	Click here for details on how this gene model was made and data restrictions if any.