ID:SRSF4_HUMAN DESCRIPTION: RecName: Full=Serine/arginine-rich splicing factor 4; AltName: Full=Pre-mRNA-splicing factor SRP75; AltName: Full=SRP001LB; AltName: Full=Splicing factor, arginine/serine-rich 4; FUNCTION: Plays a role in alternative splice site selection during pre-mRNA splicing. Represses the splicing of MAPT/Tau exon 10. SUBUNIT: Found in a pre-mRNA splicing complex with SRSF4/SFRS4, SRSF5/SFRS5, SNRNP70, SNRPA1, SRRM1 and SRRM2. Interacts with PNN. SUBCELLULAR LOCATION: Nucleus speckle. PTM: Extensively phosphorylated on serine residues in the RS domain. SIMILARITY: Belongs to the splicing factor SR family. SIMILARITY: Contains 2 RRM (RNA recognition motif) domains.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q08170
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
AK223444 - Homo sapiens mRNA for splicing factor, arginine/serine-rich 4 variant, clone: FCC112H02. BC002781 - Homo sapiens splicing factor, arginine/serine-rich 4, mRNA (cDNA clone MGC:3920 IMAGE:3619538), complete cds. AB209856 - Homo sapiens mRNA for splicing factor, arginine/serine-rich 4 variant protein. AK291509 - Homo sapiens cDNA FLJ76859 complete cds, highly similar to Homo sapiens splicing factor, arginine/serine-rich 4 (SFRS4), mRNA. L14076 - Human pre-mRNA splicing factor SRp75 mRNA, complete cds. AK293706 - Homo sapiens cDNA FLJ50118 complete cds, highly similar to Splicing factor, arginine/serine-rich 4. BT007415 - Homo sapiens splicing factor, arginine/serine-rich 4 mRNA, complete cds. DQ893846 - Synthetic construct Homo sapiens clone IMAGE:100008306; FLH164911.01L; RZPDo839D07157D splicing factor, arginine/serine-rich 4 (SFRS4) gene, encodes complete protein. KJ892129 - Synthetic construct Homo sapiens clone ccsbBroadEn_01523 SRSF4 gene, encodes complete protein. AB527790 - Synthetic construct DNA, clone: pF1KB5874, Homo sapiens SFRS4 gene for splicing factor, arginine/serine-rich 4, without stop codon, in Flexi system. CU678194 - Synthetic construct Homo sapiens gateway clone IMAGE:100019665 5' read SFRS4 mRNA. AK310528 - Homo sapiens cDNA, FLJ17570. JD500191 - Sequence 481215 from Patent EP1572962. JD319901 - Sequence 300925 from Patent EP1572962. JD418242 - Sequence 399266 from Patent EP1572962. JD096968 - Sequence 77992 from Patent EP1572962. JD294871 - Sequence 275895 from Patent EP1572962. JD526183 - Sequence 507207 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q08170 (Reactome details) participates in the following event(s):
R-HSA-72124 Formation of the Spliceosomal A Complex R-HSA-75096 Docking of the TAP:EJC Complex with the NPC R-HSA-72143 Lariat Formation and 5'-Splice Site Cleavage R-HSA-72139 Formation of the active Spliceosomal C (B*) complex R-HSA-72127 Formation of the Spliceosomal B Complex R-HSA-72130 Formation of an intermediate Spliceosomal C (Bact) complex R-HSA-8849157 TREX complex binds spliced, capped mRNA:CBC:EJC cotranscriptionally R-HSA-72185 mRNA polyadenylation R-HSA-72180 Cleavage of mRNA at the 3'-end R-HSA-156661 Formation of Exon Junction Complex R-HSA-159101 NXF1:NXT1 (TAP:p15) binds capped mRNA:CBC:EJC:TREX (minus DDX39B) R-HSA-72163 mRNA Splicing - Major Pathway R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-72187 mRNA 3'-end processing R-HSA-109688 Cleavage of Growing Transcript in the Termination Region R-HSA-72172 mRNA Splicing R-HSA-72202 Transport of Mature Transcript to Cytoplasm R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA R-HSA-73856 RNA Polymerase II Transcription Termination R-HSA-8953854 Metabolism of RNA R-HSA-73857 RNA Polymerase II Transcription R-HSA-74160 Gene expression (Transcription)
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
