Human Gene SQOR (ENST00000260324.12_4) from GENCODE V47lift37
  Description: sulfide quinone oxidoreductase, transcript variant 1 (from RefSeq NM_021199.4)
Gencode Transcript: ENST00000260324.12_4
Gencode Gene: ENSG00000137767.14_11
Transcript (Including UTRs)
   Position: hg19 chr15:45,927,227-45,983,479 Size: 56,253 Total Exon Count: 10 Strand: +
Coding Region
   Position: hg19 chr15:45,951,122-45,983,228 Size: 32,107 Coding Exon Count: 9 

Page IndexSequence and LinksUniProtKB CommentsPrimersGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
PathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr15:45,927,227-45,983,479)mRNA (may differ from genome)Protein (450 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsMGI
OMIMPubMedReactomeUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: SQRD_HUMAN
DESCRIPTION: RecName: Full=Sulfide:quinone oxidoreductase, mitochondrial; EC=1.-.-.-; Flags: Precursor;
FUNCTION: Catalyzes the oxidation of hydrogen sulfide, with the help of a quinone (By similarity).
COFACTOR: Binds 1 FAD per subunit (By similarity).
SUBCELLULAR LOCATION: Mitochondrion (Probable).
SIMILARITY: Belongs to the SQRD family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 66.89 RPKM in Colon - Transverse
Total median expression: 647.52 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -33.6097-0.346 Picture PostScript Text
3' UTR -61.90251-0.247 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR023753 - Pyr_nucl-diS_OxRdtase_FAD/NAD
IPR015904 - Sulphide_quinone_reductase

Pfam Domains:
PF07992 - Pyridine nucleotide-disulphide oxidoreductase

SCOP Domains:
51735 - NAD(P)-binding Rossmann-fold domains
51905 - FAD/NAD(P)-binding domain
51971 - Nucleotide-binding domain
53335 - S-adenosyl-L-methionine-dependent methyltransferases

ModBase Predicted Comparative 3D Structure on Q9Y6N5
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details Gene DetailsGene Details 
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 RGDEnsembl WormBase 
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0016491 oxidoreductase activity
GO:0048038 quinone binding
GO:0070224 sulfide:quinone oxidoreductase activity

Biological Process:
GO:0055114 oxidation-reduction process
GO:0070221 sulfide oxidation, using sulfide:quinone oxidoreductase
GO:0070813 hydrogen sulfide metabolic process

Cellular Component:
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane


-  Descriptions from all associated GenBank mRNAs
  AK130140 - Homo sapiens cDNA FLJ26630 fis, clone MPC05384, highly similar to Mus musculus flavo-binding protein mRNA.
AK222463 - Homo sapiens mRNA for sulfide dehydrogenase like, clone: adKA01523.
AF042284 - Homo sapiens unknown mRNA.
E08981 - cDNA encoding a novel polypeptide derived from glioblastoma.
AF151802 - Homo sapiens CGI-44 protein mRNA, complete cds.
AK313111 - Homo sapiens cDNA, FLJ93596, highly similar to Homo sapiens sulfide quinone reductase-like (yeast) (SQRDL), mRNA.
BC016836 - Homo sapiens sulfide quinone reductase-like (yeast), mRNA (cDNA clone MGC:10012 IMAGE:3884024), complete cds.
E08980 - cDNA encoding a novel polypeptide derived from glioblastoma.
DQ894625 - Synthetic construct Homo sapiens clone IMAGE:100009085; FLH177022.01L; RZPDo839C03123D sulfide quinone reductase-like (yeast) (SQRDL) gene, encodes complete protein.
KJ899381 - Synthetic construct Homo sapiens clone ccsbBroadEn_08775 SQRDL gene, encodes complete protein.
DQ891446 - Synthetic construct clone IMAGE:100004076; FLH177025.01X; RZPDo839C03124D sulfide quinone reductase-like (yeast) (SQRDL) gene, encodes complete protein.
AF118085 - Homo sapiens PRO1975 mRNA, complete cds.
JD355690 - Sequence 336714 from Patent EP1572962.
JD308610 - Sequence 289634 from Patent EP1572962.
JD240272 - Sequence 221296 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  BioCyc Knowledge Library
PWY-7927 - sulfide oxidation IV (metazoa)

Reactome (by CSHL, EBI, and GO)

Protein Q9Y6N5 (Reactome details) participates in the following event(s):

R-HSA-1614605 Persulfide sulfur is dioxygenated
R-HSA-1614618 Persulfide sulfur is transferred onto sulfite
R-HSA-1614665 SQR oxidizes sulfide to bound persulfide
R-HSA-1614517 Sulfide oxidation to sulfate
R-HSA-1614558 Degradation of cysteine and homocysteine
R-HSA-1614635 Sulfur amino acid metabolism
R-HSA-71291 Metabolism of nitrogenous molecules
R-HSA-1430728 Metabolism

-  Other Names for This Gene
  Alternate Gene Symbols: CGI-44, ENST00000260324.1, ENST00000260324.10, ENST00000260324.11, ENST00000260324.2, ENST00000260324.3, ENST00000260324.4, ENST00000260324.5, ENST00000260324.6, ENST00000260324.7, ENST00000260324.8, ENST00000260324.9, NM_021199, Q9UQM8, Q9Y6N5, SQOR , SQOR_HUMAN, SQRDL , uc317gjt.1, uc317gjt.2
UCSC ID: ENST00000260324.12_4
RefSeq Accession: NM_021199.4
Protein: Q9Y6N5 (aka SQRD_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.