ID:SPY1_HUMAN DESCRIPTION: RecName: Full=Protein sprouty homolog 1; Short=Spry-1; FUNCTION: May function as an antagonist of fibroblast growth factor (FGF) pathways and may negatively modulate respiratory organogenesis. SUBCELLULAR LOCATION: Cytoplasm. Membrane; Peripheral membrane protein. Note=Found in the cytoplasm in unstimulated cells but is translocated to the membrane ruffles in cells stimulated with EGF (epidermal growth factor). INDUCTION: By FGF signaling. DOMAIN: The Cys-rich domain is responsible for the localization of the protein to the membrane ruffles. SIMILARITY: Belongs to the sprouty family. SIMILARITY: Contains 1 SPR (sprouty) domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O43609
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0000132 establishment of mitotic spindle orientation GO:0001656 metanephros development GO:0001657 ureteric bud development GO:0001759 organ induction GO:0007275 multicellular organism development GO:0008285 negative regulation of cell proliferation GO:0009966 regulation of signal transduction GO:0034260 negative regulation of GTPase activity GO:0040037 negative regulation of fibroblast growth factor receptor signaling pathway GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway GO:0043407 negative regulation of MAP kinase activity GO:0046580 negative regulation of Ras protein signal transduction GO:0051387 negative regulation of neurotrophin TRK receptor signaling pathway GO:0060449 bud elongation involved in lung branching GO:0060940 epithelial to mesenchymal transition involved in cardiac fibroblast development GO:0070373 negative regulation of ERK1 and ERK2 cascade
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
