Human Gene SPRR2A (ENST00000392653.3_7) from GENCODE V47lift37

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Description: small proline rich protein 2A (from RefSeq NM_005988.3)
Gencode Transcript: ENST00000392653.3_7
Gencode Gene: ENSG00000241794.2_9
Transcript (Including UTRs)
Position: hg19 chr1:153,028,596-153,029,988 Size: 1,393 Total Exon Count: 2 Strand: -
Coding Region
Position: hg19 chr1:153,028,993-153,029,211 Size: 219 Coding Exon Count: 1

Page Index	Sequence and Links	UniProtKB Comments	Primers	CTD	Gene Alleles
RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species	GO Annotations
mRNA Descriptions	Pathways	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr1:153,028,596-153,029,988)			mRNA (may differ from genome)		Protein (72 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	MGI	OMIM	PubMed	Reactome	UniProtKB
Wikipedia	BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: SPR2A_HUMAN DESCRIPTION: RecName: Full=Small proline-rich protein 2A; Short=SPR-2A; AltName: Full=2-1; FUNCTION: Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane. SUBCELLULAR LOCATION: Cytoplasm. INDUCTION: During squamous differentiation of epidermal keratinocytes. SIMILARITY: Belongs to the cornifin (SPRR) family.

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D013749 Tetrachlorodibenzodioxin C014347 decitabine C105260 4-tert-octylphenol D017632 Asbestos, Serpentine D001564 Benzo(a)pyrene D004054 Diethylstilbestrol D004958 Estradiol D004997 Ethinyl Estradiol D005480 Flurbiprofen D019833 Genistein more ... click here to view the complete list

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 1851.25 RPKM in Esophagus - Mucosa Total median expression: 1984.22 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-11.60	61	-0.190	Picture	PostScript	Text
3' UTR	-105.50	397	-0.266	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR026075 - SPRR/LCE

Pfam Domains:
PF14820 - Small proline-rich 2

ModBase Predicted Comparative 3D Structure on P35326


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0005198 structural molecule activity GO:0005515 protein binding Biological Process: GO:0008544 epidermis development GO:0018149 peptide cross-linking GO:0030216 keratinocyte differentiation GO:0031424 keratinization GO:0070268 cornification Cellular Component: GO:0001533 cornified envelope GO:0005737 cytoplasm GO:0005829 cytosol

Descriptions from all associated GenBank mRNAs


	BC128049 - Homo sapiens small proline-rich protein 2A, mRNA (cDNA clone MGC:158955 IMAGE:40115066), complete cds. JD500953 - Sequence 481977 from Patent EP1572962. JD550171 - Sequence 531195 from Patent EP1572962. JD065383 - Sequence 46407 from Patent EP1572962. JD218570 - Sequence 199594 from Patent EP1572962. JD381730 - Sequence 362754 from Patent EP1572962. JD260407 - Sequence 241431 from Patent EP1572962. JD359900 - Sequence 340924 from Patent EP1572962. JD066987 - Sequence 48011 from Patent EP1572962. JD088714 - Sequence 69738 from Patent EP1572962. JD429434 - Sequence 410458 from Patent EP1572962. JD413225 - Sequence 394249 from Patent EP1572962. JD504062 - Sequence 485086 from Patent EP1572962. JD245324 - Sequence 226348 from Patent EP1572962. BC096108 - Homo sapiens small proline-rich protein 2A, mRNA (cDNA clone MGC:116754 IMAGE:40002232), complete cds. BC096109 - Homo sapiens small proline-rich protein 2A, mRNA (cDNA clone MGC:116755 IMAGE:40002234), complete cds. BC096110 - Homo sapiens small proline-rich protein 2A, mRNA (cDNA clone MGC:116756 IMAGE:40002235), complete cds. BC096111 - Homo sapiens small proline-rich protein 2A, mRNA (cDNA clone MGC:116757 IMAGE:40002236), complete cds. AK311939 - Homo sapiens cDNA, FLJ92206, Homo sapiens small proline-rich protein 2A (SPRR2A), mRNA. KJ897597 - Synthetic construct Homo sapiens clone ccsbBroadEn_06991 SPRR2A gene, encodes complete protein.

Biochemical and Signaling Pathways


	Reactome (by CSHL, EBI, and GO) Protein P35326 (Reactome details) participates in the following event(s): R-HSA-6810937 Lamellar bodies bind the early cornified envelope R-HSA-6814734 CDSN binds the cornified envelope R-HSA-6814298 Late envelope proteins bind cornified envelope:CDSN R-HSA-6814387 CASP14 cleaves filaggrin R-HSA-6809371 Formation of the cornified envelope R-HSA-6805567 Keratinization R-HSA-1266738 Developmental Biology

Other Names for This Gene


	Alternate Gene Symbols: B2R4T3, D3DV35, ENST00000392653.1, ENST00000392653.2, NM_005988, P35326, Q5T529, SPR2A_HUMAN, SPRR2A , uc318vgs.1, uc318vgs.2 UCSC ID: ENST00000392653.3_7 RefSeq Accession: NM_005988.3 Protein: P35326 (aka SPR2A_HUMAN or SP2A_HUMAN)

Gene Model Information


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Methods, Credits, and Use Restrictions


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