ID:SPC24_HUMAN DESCRIPTION: RecName: Full=Kinetochore protein Spc24; Short=hSpc24; FUNCTION: Acts as a component of the essential kinetochore- associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore. SUBUNIT: Component of the NDC80 complex, which consists of NDC80/HEC1, CDCA1, SPBC24 and SPBC25. The NDC80 complex is formed by two subcomplexes composed of NDC80/HEC1-CDCA1 and SPBC24- SPBC25. Each subcomplex is formed by parallel interactions through the coiled-coil domains of individual subunits. Formation of a tetrameric complex is mediated by interactions between the C- terminal regions of both subunits of the NDC80/HEC1-CDCA1 subcomplex and the N-terminal regions of both subunits of the SPBC24-SPBC25 complex. The tetrameric NDC80 complex has an elongated rod-like structure with globular domains at either end. INTERACTION: Q9HBM1:SPC25; NbExp=5; IntAct=EBI-999900, EBI-999909; SUBCELLULAR LOCATION: Nucleus. Chromosome, centromere, kinetochore. Note=Localizes to kinetochores from late prophase to anaphase. Localizes specifically to the outer plate of the kinetochore. SIMILARITY: Belongs to the SPC24 family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q8NBT2
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
AK075287 - Homo sapiens cDNA FLJ90806 fis, clone Y79AA1000750. JD277110 - Sequence 258134 from Patent EP1572962. JD314022 - Sequence 295046 from Patent EP1572962. JD503163 - Sequence 484187 from Patent EP1572962. JD148380 - Sequence 129404 from Patent EP1572962. JD463897 - Sequence 444921 from Patent EP1572962. JD478645 - Sequence 459669 from Patent EP1572962. JD543363 - Sequence 524387 from Patent EP1572962. JD222933 - Sequence 203957 from Patent EP1572962. JD543362 - Sequence 524386 from Patent EP1572962. JD222932 - Sequence 203956 from Patent EP1572962. JD249977 - Sequence 231001 from Patent EP1572962. JD135554 - Sequence 116578 from Patent EP1572962. JD483601 - Sequence 464625 from Patent EP1572962. JD278627 - Sequence 259651 from Patent EP1572962. JD431020 - Sequence 412044 from Patent EP1572962. JD065825 - Sequence 46849 from Patent EP1572962. JD160425 - Sequence 141449 from Patent EP1572962. JD249726 - Sequence 230750 from Patent EP1572962. JD478506 - Sequence 459530 from Patent EP1572962. JD543186 - Sequence 524210 from Patent EP1572962. JD283379 - Sequence 264403 from Patent EP1572962. JD331480 - Sequence 312504 from Patent EP1572962. JD204216 - Sequence 185240 from Patent EP1572962. JD038342 - Sequence 19366 from Patent EP1572962. JD241744 - Sequence 222768 from Patent EP1572962. JD146149 - Sequence 127173 from Patent EP1572962. JD263889 - Sequence 244913 from Patent EP1572962. JD299435 - Sequence 280459 from Patent EP1572962. JD356714 - Sequence 337738 from Patent EP1572962. JD356713 - Sequence 337737 from Patent EP1572962. JD346646 - Sequence 327670 from Patent EP1572962. JD505157 - Sequence 486181 from Patent EP1572962. AK303157 - Homo sapiens cDNA FLJ51585 complete cds, moderately similar to Homo sapiens spindle pole body component 24 homolog (SPBC24), mRNA. JD107667 - Sequence 88691 from Patent EP1572962. JD518500 - Sequence 499524 from Patent EP1572962. JD357859 - Sequence 338883 from Patent EP1572962. JD341399 - Sequence 322423 from Patent EP1572962. JD311662 - Sequence 292686 from Patent EP1572962. JD379615 - Sequence 360639 from Patent EP1572962. JD120529 - Sequence 101553 from Patent EP1572962. JD206476 - Sequence 187500 from Patent EP1572962. JD064469 - Sequence 45493 from Patent EP1572962. JD545497 - Sequence 526521 from Patent EP1572962. JD333012 - Sequence 314036 from Patent EP1572962. JD069634 - Sequence 50658 from Patent EP1572962. JD513864 - Sequence 494888 from Patent EP1572962. JD069633 - Sequence 50657 from Patent EP1572962. JD513863 - Sequence 494887 from Patent EP1572962. JD513865 - Sequence 494889 from Patent EP1572962. JD414437 - Sequence 395461 from Patent EP1572962. JD524654 - Sequence 505678 from Patent EP1572962. JD352427 - Sequence 333451 from Patent EP1572962. JD450729 - Sequence 431753 from Patent EP1572962. JD534120 - Sequence 515144 from Patent EP1572962. JD295892 - Sequence 276916 from Patent EP1572962. JD562274 - Sequence 543298 from Patent EP1572962. JD262569 - Sequence 243593 from Patent EP1572962. JD154374 - Sequence 135398 from Patent EP1572962. JD326191 - Sequence 307215 from Patent EP1572962. JD295891 - Sequence 276915 from Patent EP1572962. JD295890 - Sequence 276914 from Patent EP1572962. JD562273 - Sequence 543297 from Patent EP1572962. JD296980 - Sequence 278004 from Patent EP1572962. JD562272 - Sequence 543296 from Patent EP1572962. JD154373 - Sequence 135397 from Patent EP1572962. AK303266 - Homo sapiens cDNA FLJ51584 complete cds, highly similar to Homo sapiens spindle pole body component 24 homolog (SPBC24), mRNA. BC105037 - Homo sapiens SPC24, NDC80 kinetochore complex component, homolog (S. cerevisiae), mRNA (cDNA clone MGC:132697 IMAGE:8144040), complete cds. BC105039 - Homo sapiens SPC24, NDC80 kinetochore complex component, homolog (S. cerevisiae), mRNA (cDNA clone MGC:132699 IMAGE:8144042), complete cds. LF384523 - JP 2014500723-A/192026: Polycomb-Associated Non-Coding RNAs. KJ895609 - Synthetic construct Homo sapiens clone ccsbBroadEn_05003 SPC24 gene, encodes complete protein. AY456387 - Homo sapiens kinetochore protein Spc24 mRNA, complete cds. LF375799 - JP 2014500723-A/183302: Polycomb-Associated Non-Coding RNAs. LF375800 - JP 2014500723-A/183303: Polycomb-Associated Non-Coding RNAs. LF375801 - JP 2014500723-A/183304: Polycomb-Associated Non-Coding RNAs. LF375802 - JP 2014500723-A/183305: Polycomb-Associated Non-Coding RNAs. LF375803 - JP 2014500723-A/183306: Polycomb-Associated Non-Coding RNAs. JD344318 - Sequence 325342 from Patent EP1572962. JD465589 - Sequence 446613 from Patent EP1572962. MA620100 - JP 2018138019-A/192026: Polycomb-Associated Non-Coding RNAs. MA611376 - JP 2018138019-A/183302: Polycomb-Associated Non-Coding RNAs. MA611377 - JP 2018138019-A/183303: Polycomb-Associated Non-Coding RNAs. MA611378 - JP 2018138019-A/183304: Polycomb-Associated Non-Coding RNAs. MA611379 - JP 2018138019-A/183305: Polycomb-Associated Non-Coding RNAs. MA611380 - JP 2018138019-A/183306: Polycomb-Associated Non-Coding RNAs.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q8NBT2 (Reactome details) participates in the following event(s):
R-HSA-141409 Mad1 binds kinetochore R-HSA-375302 Kinetochore capture of astral microtubules R-HSA-5666129 CDC42:GTP recruits DIAPH2-2 to kinetochores R-HSA-5666169 Kinetochore capture of astral microtubules is positively regulated by CDC42:GTP:p-S196-DIAPH2-2 R-HSA-141431 MAD2 associates with the Mad1 kinetochore complex R-HSA-141439 Release of activated MAD2 from kinetochores R-HSA-2467811 Separation of sister chromatids R-HSA-2467809 ESPL1 (Separase) cleaves centromeric cohesin R-HSA-5666160 AURKB phosphorylates DIAPH2-2 at kinetochores R-HSA-141422 MAD2 converted to an inhibitory state via interaction with Mad1 R-HSA-1638821 PP2A-B56 dephosphorylates centromeric cohesin R-HSA-1638803 Phosphorylation of cohesin by PLK1 at centromeres R-HSA-2468287 CDK1 phosphorylates CDCA5 (Sororin) at centromeres R-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-68877 Mitotic Prometaphase R-HSA-5663220 RHO GTPases Activate Formins R-HSA-2500257 Resolution of Sister Chromatid Cohesion R-HSA-2467813 Separation of Sister Chromatids R-HSA-141424 Amplification of signal from the kinetochores R-HSA-68886 M Phase R-HSA-195258 RHO GTPase Effectors R-HSA-68882 Mitotic Anaphase R-HSA-69618 Mitotic Spindle Checkpoint R-HSA-69278 Cell Cycle (Mitotic) R-HSA-194315 Signaling by Rho GTPases R-HSA-2555396 Mitotic Metaphase and Anaphase R-HSA-69620 Cell Cycle Checkpoints R-HSA-1640170 Cell Cycle R-HSA-162582 Signal Transduction
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
