ID:SOX1_HUMAN DESCRIPTION: RecName: Full=Transcription factor SOX-1; FUNCTION: Transcriptional activator. May function as a switch in neuronal development. Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation (By similarity). INTERACTION: P40763:STAT3; NbExp=2; IntAct=EBI-2935583, EBI-518675; SUBCELLULAR LOCATION: Nucleus (Probable). TISSUE SPECIFICITY: Mainly expressed in the developing central nervous system. SIMILARITY: Contains 1 HMG box DNA-binding domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O00570
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0001046 core promoter sequence-specific DNA binding GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0003677 DNA binding GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0005515 protein binding GO:0043565 sequence-specific DNA binding
Biological Process: GO:0001764 neuron migration GO:0002089 lens morphogenesis in camera-type eye GO:0006325 chromatin organization GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006366 transcription from RNA polymerase II promoter GO:0007399 nervous system development GO:0021521 ventral spinal cord interneuron specification GO:0021879 forebrain neuron differentiation GO:0021884 forebrain neuron development GO:0030900 forebrain development GO:0045944 positive regulation of transcription from RNA polymerase II promoter GO:1990830 cellular response to leukemia inhibitory factor
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
