Human Gene SOCS1 (ENST00000332029.4_6) from GENCODE V47lift37 |
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 Sequence and Links to Tools and Databases
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Comments and Description Text from UniProtKB
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ID: Q4JHT5_HUMAN
DESCRIPTION: SubName: Full=Suppressor of cytokine signaling 1; SubName: Full=cDNA FLJ45719 fis, clone FELNG2001953, highly similar to Suppressor of cytokine signaling 1;
PATHWAY: Protein modification; protein ubiquitination.
SIMILARITY: Contains 1 SOCS box domain.
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Primer design for this transcript
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MalaCards Disease Associations
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Comparative Toxicogenomics Database (CTD)
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 Common Gene Haplotype Alleles
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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
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Microarray Expression Data
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mRNA Secondary Structure of 3' and 5' UTRs
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The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
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Protein Domain and Structure Information
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InterPro Domains: Graphical view of domain structure
IPR000980 - SH2
IPR001496 - SOCS_C
Pfam Domains:
PF00017 - SH2 domain
SCOP Domains:
158235 - SOCS box-like
55550 - SH2 domain
ModBase Predicted Comparative 3D Structure on Q4JHT5
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
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Orthologous Genes in Other Species
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Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
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Gene Ontology (GO) Annotations with Structured Vocabulary
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Descriptions from all associated GenBank mRNAs
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LF212663 - JP 2014500723-A/20166: Polycomb-Associated Non-Coding RNAs.
AB000676 - Homo sapiens mRNA for JAB, partial cds.
U88326 - Human suppressor of cytokine signalling-1 (SOCS-1) mRNA, complete cds.
AB000734 - Homo sapiens mRNA for TIP3, complete cds.
AK127621 - Homo sapiens cDNA FLJ45719 fis, clone FELNG2001953, highly similar to Suppressor of cytokine signaling 1.
AB005043 - Homo sapiens mRNA for STAT induced STAT inhibitor-1, complete cds.
JD563134 - Sequence 544158 from Patent EP1572962.
JD172996 - Sequence 154020 from Patent EP1572962.
JD487558 - Sequence 468582 from Patent EP1572962.
JD075868 - Sequence 56892 from Patent EP1572962.
JD540226 - Sequence 521250 from Patent EP1572962.
JD560245 - Sequence 541269 from Patent EP1572962.
JD416045 - Sequence 397069 from Patent EP1572962.
BC148542 - Synthetic construct Homo sapiens clone IMAGE:100015498, MGC:183062 suppressor of cytokine signaling 1 (SOCS1) mRNA, encodes complete protein.
BC153088 - Synthetic construct Homo sapiens clone IMAGE:100016379, MGC:184312 suppressor of cytokine signaling 1 (SOCS1) mRNA, encodes complete protein.
AB464719 - Synthetic construct DNA, clone: pF1KB8763, Homo sapiens SOCS1 gene for suppressor of cytokine signaling 1, without stop codon, in Flexi system.
BC029307 - Homo sapiens suppressor of cytokine signaling 1, mRNA (cDNA clone IMAGE:5179306), with apparent retained intron.
JD474898 - Sequence 455922 from Patent EP1572962.
MA448240 - JP 2018138019-A/20166: Polycomb-Associated Non-Coding RNAs.
MP067513 - Sequence 17 from Patent WO2018232288.
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Biochemical and Signaling Pathways
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BioCarta from NCI Cancer Genome Anatomy Project
h_ghPathway - Growth Hormone Signaling Pathway
h_il2rbPathway - IL-2 Receptor Beta Chain in T cell Activation
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Other Names for This Gene
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Alternate Gene Symbols: ENST00000332029.1, ENST00000332029.2, ENST00000332029.3, hCG_14617 , NM_003745, Q4JHT5, Q4JHT5_HUMAN, SOCS1 , uc317tio.1, uc317tio.2
UCSC ID: ENST00000332029.4_6
RefSeq Accession: NM_003745.2
Protein: Q4JHT5
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Gene Model Information
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for a detailed description of the fields of the table above.
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Methods, Credits, and Use Restrictions
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for details on how this gene model was made and data restrictions if any.
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US Server
