ID:RU2A_HUMAN DESCRIPTION: RecName: Full=U2 small nuclear ribonucleoprotein A'; Short=U2 snRNP A'; FUNCTION: This protein is associated with sn-RNP U2. It helps the A' protein to bind stem loop IV of U2 snRNA. SUBUNIT: Identified in the spliceosome C complex. Found in a pre- mRNA splicing complex with SFRS4, SFRS5, SNRNP70, SNRPA1, SRRM1 and SRRM2. Found in a pre-mRNA exonic splicing enhancer (ESE) complex with SNRNP70, SNRPA1, SRRM1 and TRA2B. SUBCELLULAR LOCATION: Nucleus. SIMILARITY: Belongs to the U2 small nuclear ribonucleoprotein A family. SIMILARITY: Contains 4 LRR (leucine-rich) repeats. SIMILARITY: Contains 1 LRRCT domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P09661
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
BC071717 - Homo sapiens small nuclear ribonucleoprotein polypeptide A', mRNA (cDNA clone MGC:88013 IMAGE:4514975), complete cds. AK223110 - Homo sapiens mRNA for small nuclear ribonucleoprotein polypeptide A' variant, clone: KAT09545. BC022816 - Homo sapiens small nuclear ribonucleoprotein polypeptide A', mRNA (cDNA clone MGC:39248 IMAGE:4904205), complete cds. AK223070 - Homo sapiens mRNA for small nuclear ribonucleoprotein polypeptide A' variant, clone: KAT01812. LF384281 - JP 2014500723-A/191784: Polycomb-Associated Non-Coding RNAs. X13482 - Human mRNA for U2 snRNP-specific A' protein. BC067846 - Homo sapiens small nuclear ribonucleoprotein polypeptide A', mRNA (cDNA clone MGC:87438 IMAGE:30330402), complete cds. AK090986 - Homo sapiens cDNA FLJ33667 fis, clone BRAMY2027782, moderately similar to U2 SMALL NUCLEAR RIBONUCLEOPROTEIN A'. AJ130971 - Homo sapiens mRNA for U2 snRNP-specific A' protein, alternative transcript 4. AJ130972 - Homo sapiens mRNA for U2 snRNP-specific A' protein, alternative transcript 3. AK312200 - Homo sapiens cDNA, FLJ92488, highly similar to Homo sapiens small nuclear ribonucleoprotein polypeptide A'(SNRPA1), mRNA. KJ892173 - Synthetic construct Homo sapiens clone ccsbBroadEn_01567 SNRPA1 gene, encodes complete protein. DQ892838 - Synthetic construct clone IMAGE:100005468; FLH190173.01X; RZPDo839F0475D small nuclear ribonucleoprotein polypeptide A' (SNRPA1) gene, encodes complete protein. DQ896084 - Synthetic construct Homo sapiens clone IMAGE:100010544; FLH190169.01L; RZPDo839F0465D small nuclear ribonucleoprotein polypeptide A' (SNRPA1) gene, encodes complete protein. AB528428 - Synthetic construct DNA, clone: pF1KB9903, Homo sapiens SNRPA1 gene for small nuclear ribonucleoprotein polypeptide A', without stop codon, in Flexi system. CU692724 - Synthetic construct Homo sapiens gateway clone IMAGE:100021871 5' read SNRPA1 mRNA. LF368167 - JP 2014500723-A/175670: Polycomb-Associated Non-Coding RNAs. LF368166 - JP 2014500723-A/175669: Polycomb-Associated Non-Coding RNAs. AK290078 - Homo sapiens cDNA FLJ75425 complete cds, highly similar to Homo sapiens small nuclear ribonucleoprotein polypeptide A', mRNA. LF368164 - JP 2014500723-A/175667: Polycomb-Associated Non-Coding RNAs. LF368163 - JP 2014500723-A/175666: Polycomb-Associated Non-Coding RNAs. LF368162 - JP 2014500723-A/175665: Polycomb-Associated Non-Coding RNAs. JD057824 - Sequence 38848 from Patent EP1572962. JD435174 - Sequence 416198 from Patent EP1572962. JD098353 - Sequence 79377 from Patent EP1572962. JD057880 - Sequence 38904 from Patent EP1572962. MA619858 - JP 2018138019-A/191784: Polycomb-Associated Non-Coding RNAs. MA603744 - JP 2018138019-A/175670: Polycomb-Associated Non-Coding RNAs. MA603743 - JP 2018138019-A/175669: Polycomb-Associated Non-Coding RNAs. MA603741 - JP 2018138019-A/175667: Polycomb-Associated Non-Coding RNAs. MA603740 - JP 2018138019-A/175666: Polycomb-Associated Non-Coding RNAs. MA603739 - JP 2018138019-A/175665: Polycomb-Associated Non-Coding RNAs.
Biochemical and Signaling Pathways
BioCarta from NCI Cancer Genome Anatomy Project h_smPathway - Spliceosomal Assembly
Reactome (by CSHL, EBI, and GO)
Protein P09661 (Reactome details) participates in the following event(s):
R-HSA-72124 Formation of the Spliceosomal A Complex R-HSA-72143 Lariat Formation and 5'-Splice Site Cleavage R-HSA-72139 Formation of the active Spliceosomal C (B*) complex R-HSA-72127 Formation of the Spliceosomal B Complex R-HSA-72130 Formation of an intermediate Spliceosomal C (Bact) complex R-HSA-156661 Formation of Exon Junction Complex R-HSA-8950505 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-72163 mRNA Splicing - Major Pathway R-HSA-9020591 Interleukin-12 signaling R-HSA-72172 mRNA Splicing R-HSA-447115 Interleukin-12 family signaling R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA R-HSA-449147 Signaling by Interleukins R-HSA-8953854 Metabolism of RNA R-HSA-1280215 Cytokine Signaling in Immune system R-HSA-168256 Immune System
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
