ID:RU17_HUMAN DESCRIPTION: RecName: Full=U1 small nuclear ribonucleoprotein 70 kDa; Short=U1 snRNP 70 kDa; Short=U1-70K; Short=snRNP70; FUNCTION: Mediates the splicing of pre-mRNA by binding to the loop I region of U1-snRNA. The truncated isoforms cannot bind U1-snRNA. SUBUNIT: Interacts with SCNM1 (By similarity). Found in a pre-mRNA splicing complex with SFRS4, SFRS5, SNRNP70, SNRPA1, SRRM1 and SRRM2. Found in a pre-mRNA exonic splicing enhancer (ESE) complex with SNRNP70, SNRPA1, SRRM1 and TRA2B/SFRS10. Interacts with dephosphorylated SFRS13A and SFPQ. Interacts with NUDT21/CPSF5, CPSF6, SCAF11, and ZRANB2. INTERACTION: P49760:CLK2; NbExp=2; IntAct=EBI-1049228, EBI-750020; SUBCELLULAR LOCATION: Nucleus. Nucleus speckle (By similarity). Nucleus, nucleoplasm (By similarity). Note=Colocalizes with SCNM1 and LUC7L2 in nuclear speckles (By similarity). PTM: The N-terminus is blocked. PTM: Extensively phosphorylated on serine residues in the C- terminal region. MISCELLANEOUS: Major ribonucleoprotein antigen recognized by the sera from patients with autoimmune diseases, such as systemic lupus erythematosus. SIMILARITY: Contains 1 RRM (RNA recognition motif) domain. SEQUENCE CAUTION: Sequence=CAA28352.1; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=CAA29964.1; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=CAA29966.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P08621
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
AK293120 - Homo sapiens cDNA FLJ77404 complete cds, highly similar to Homo sapiens small nuclear ribonucleoprotein 70kDa polypeptide (RNP antigen) (SNRP70), transcript variant 1, mRNA. X06817 - Human mRNA for hU1-70k snRNP protein (RNPH1, part 1). AK096783 - Homo sapiens cDNA FLJ39464 fis, clone PROST2012140, highly similar to U1 SMALL NUCLEAR RIBONUCLEOPROTEIN 70 KDA. BC001315 - Homo sapiens small nuclear ribonucleoprotein 70kDa (U1), mRNA (cDNA clone MGC:5527 IMAGE:3454479), complete cds. X04654 - Human mRNA for U1 RNA-associated 70K protein. M22636 - Human U1 small nuclear ribonucleoprotein 70 kd protein mRNA, complete cds. X06815 - Human mRNA for hU1-70K small nuclear RNP protein (RNP FL1.7) (nonproductive). JD468786 - Sequence 449810 from Patent EP1572962. JD200329 - Sequence 181353 from Patent EP1572962. X06813 - Human mRNA for hU1-70K snRNP protein (RNPW1, part 1). JD458233 - Sequence 439257 from Patent EP1572962. KJ897588 - Synthetic construct Homo sapiens clone ccsbBroadEn_06982 SNRNP70 gene, encodes complete protein. AB463266 - Synthetic construct DNA, clone: pF1KB5169, Homo sapiens SNRP70 gene for small nuclear ribonucleoprotein 70kDa polypeptide, without stop codon, in Flexi system. X84841 - H.sapiens mRNA for 68kDa (U1) ribonucleoprotein. X06818 - Human mRNA for hU1-70K snRNP protein (RNPH2, part 1). X06812 - Human mRNA for hU1-70K snRNP protein (RNP8). X07401 - Human mRNA for hU1-70K snRNP protein (RNP6). AL832819 - Homo sapiens mRNA; cDNA DKFZp667C0424 (from clone DKFZp667C0424). AK056808 - Homo sapiens cDNA FLJ32246 fis, clone PROST1000097, highly similar to U1 SMALL NUCLEAR RIBONUCLEOPROTEIN 70 KDA. AL117507 - Homo sapiens mRNA; cDNA DKFZp434F1935 (from clone DKFZp434F1935); partial cds. AK027127 - Homo sapiens cDNA: FLJ23474 fis, clone HSI13633, highly similar to HSU170S6 Human mRNA for hU1-70K small nuclear RNP protein. X06814 - Human mRNA for hU1-70K small nuclear RNP protein (RNP12). AL117399 - Homo sapiens mRNA; cDNA DKFZp434N041 (from clone DKFZp434N041); partial cds. AK092927 - Homo sapiens cDNA FLJ35608 fis, clone SPLEN2009803. AX747810 - Sequence 1335 from Patent EP1308459. BC000342 - Homo sapiens small nuclear ribonucleoprotein 70kDa (U1), mRNA (cDNA clone IMAGE:2822991), complete cds. X06816 - Human mRNA for hU1-70K small nuclear RNP protein (RNP3). X07402 - Human mRNA for hU1-70k snRNP protein (RNPH1, part 2). X06811 - Human mRNA for U1-70K snRNP protein (RNP11). X07403 - Human mRNA for hU1-70K snRNP protein (RNPH2, part 2). JD446564 - Sequence 427588 from Patent EP1572962. X06819 - Human mRNA for hU1-70K snRNP protein (RNPW1, part 2). JD467503 - Sequence 448527 from Patent EP1572962. JD157152 - Sequence 138176 from Patent EP1572962. JD275891 - Sequence 256915 from Patent EP1572962.
Biochemical and Signaling Pathways
BioCarta from NCI Cancer Genome Anatomy Project h_smPathway - Spliceosomal Assembly
Reactome (by CSHL, EBI, and GO)
Protein P08621 (Reactome details) participates in the following event(s):
R-HSA-72107 Formation of the Spliceosomal E complex R-HSA-72130 Formation of an intermediate Spliceosomal C (Bact) complex R-HSA-72124 Formation of the Spliceosomal A Complex R-HSA-72127 Formation of the Spliceosomal B Complex R-HSA-72163 mRNA Splicing - Major Pathway R-HSA-72172 mRNA Splicing R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA R-HSA-8953854 Metabolism of RNA
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
