ID:SNF8_HUMAN DESCRIPTION: RecName: Full=Vacuolar-sorting protein SNF8; AltName: Full=ELL-associated protein of 30 kDa; AltName: Full=ESCRT-II complex subunit VPS22; Short=hVps22; FUNCTION: Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. The ESCRT-II complex may also play a role in transcription regulation by participating in derepression of transcription by RNA polymerase II, possibly via its interaction with ELL. Required for degradation of both endocytosed EGF and EGFR, but not for the EGFR ligand-mediated internalization. It is also required for the degradation of CXCR4. SUBUNIT: Component of the endosomal sorting complex required for transport II (ESCRT-II), composed of SNF8, VPS25 and VPS36. SNF8 is essential for the stability of the ESCRT-II complex. ESCRT-II interacts with ELL. Interacts with TSG101 (via the C-terminal domain). Interacts with RILPL1 (via the N-terminal domain); which recruits ESCRT-II to the endosome membranes. Interacts with 14-3-3 proteins. SUBCELLULAR LOCATION: Cytoplasm. Endosome membrane. Nucleus (Probable). Late endosome membrane. Note=Recruited to the endosome membrane to participate in vesicle formation. SIMILARITY: Belongs to the SNF8 family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q96H20
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0005515 protein binding GO:0008022 protein C-terminus binding GO:0008134 transcription factor binding GO:0016247 channel regulator activity GO:0042803 protein homodimerization activity GO:0047485 protein N-terminus binding
Biological Process: GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006357 regulation of transcription from RNA polymerase II promoter GO:0010628 positive regulation of gene expression GO:0010797 regulation of multivesicular body size involved in endosome transport GO:0015031 protein transport GO:0016197 endosomal transport GO:0016236 macroautophagy GO:0032456 endocytic recycling GO:0036258 multivesicular body assembly GO:0042176 regulation of protein catabolic process GO:0043328 protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway GO:0045022 early endosome to late endosome transport GO:0045732 positive regulation of protein catabolic process GO:0061635 regulation of protein complex stability GO:0071985 multivesicular body sorting pathway GO:1903543 positive regulation of exosomal secretion GO:1903772 regulation of viral budding via host ESCRT complex GO:0043405 regulation of MAP kinase activity
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
