ID:SNAI1_HUMAN DESCRIPTION: RecName: Full=Zinc finger protein SNAI1; AltName: Full=Protein snail homolog 1; Short=Protein sna; FUNCTION: Involved in the epithelial to mesenchymal transition (EMT) and formation and maintenance of embryonic mesoderm (By similarity). Binds to 3 E-boxes of the E-cadherin gene promoter and represses its transcription. SUBUNIT: Interacts with FBXL14 and GSK3B. Interacts with BTRC; interaction occurs when it is phosphorylated on the destruction motif. Interacts (via SNAG domain) with WTIP (via LIM domains) (By similarity). Interacts (via SNAG domain) with LIMD1 (via LIM domains), and AJUBA (via LIM domains). Interacts with LOXL2 and LOXL3. INTERACTION: P49841:GSK3B; NbExp=4; IntAct=EBI-1045459, EBI-373586; O60341:KDM1A; NbExp=4; IntAct=EBI-1045459, EBI-710124; P09874:PARP1; NbExp=10; IntAct=EBI-1045459, EBI-355676; SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=Once phosphorylated (probably on Ser-107, Ser-111, Ser-115 and Ser-119) it is exported from the nucleus to the cytoplasm where subsequent phosphorylation of the destruction motif and ubiquitination involving BTRC occurs. TISSUE SPECIFICITY: Expressed in a variety of tissues with the highest expression in kidney. Expressed in mesenchymal and epithelial cell lines. PTM: Phosphorylated by GSK3B. Once phosphorylated, it becomes a target for BTRC ubiquitination. PTM: Ubiquitinated on Lys-98, Lys-137 and Lys-146 by FBXL14 and BTRC leading to degradation. BTRC-triggered ubiquitination requires previous GSK3B-mediated SNAI1 phosphorylation. PTM: O-GlcNAcylation at Ser-112 is enhanced in hyperglycaemic conditions, it opposes phosphorylation by GSK3B, and stabilizes the protein. SIMILARITY: Belongs to the snail C2H2-type zinc-finger protein family. SIMILARITY: Contains 4 C2H2-type zinc fingers.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O95863
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding GO:0003676 nucleic acid binding GO:0003677 DNA binding GO:0005515 protein binding GO:0019900 kinase binding GO:0043565 sequence-specific DNA binding GO:0046872 metal ion binding
Biological Process: GO:0000122 negative regulation of transcription from RNA polymerase II promoter GO:0001649 osteoblast differentiation GO:0001707 mesoderm formation GO:0001837 epithelial to mesenchymal transition GO:0003198 epithelial to mesenchymal transition involved in endocardial cushion formation GO:0006357 regulation of transcription from RNA polymerase II promoter GO:0007275 multicellular organism development GO:0007498 mesoderm development GO:0010718 positive regulation of epithelial to mesenchymal transition GO:0010957 negative regulation of vitamin D biosynthetic process GO:0016477 cell migration GO:0030335 positive regulation of cell migration GO:0031069 hair follicle morphogenesis GO:0043518 negative regulation of DNA damage response, signal transduction by p53 class mediator GO:0045892 negative regulation of transcription, DNA-templated GO:0045893 positive regulation of transcription, DNA-templated GO:0060021 palate development GO:0060536 cartilage morphogenesis GO:0060707 trophoblast giant cell differentiation GO:0060806 negative regulation of cell differentiation involved in embryonic placenta development GO:0060972 left/right pattern formation GO:0061314 Notch signaling involved in heart development GO:0070828 heterochromatin organization GO:1902230 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage GO:2000810 regulation of bicellular tight junction assembly
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
