Human Gene SLPI (ENST00000338380.2_7) from GENCODE V47lift37

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Description: secretory leukocyte peptidase inhibitor (from RefSeq NM_003064.4)
Gencode Transcript: ENST00000338380.2_7
Gencode Gene: ENSG00000124107.5_9
Transcript (Including UTRs)
Position: hg19 chr20:43,880,880-43,883,205 Size: 2,326 Total Exon Count: 4 Strand: -
Coding Region
Position: hg19 chr20:43,881,056-43,883,184 Size: 2,129 Coding Exon Count: 4

Page Index	Sequence and Links	Primers	MalaCards	CTD	Gene Alleles
RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species	GO Annotations
mRNA Descriptions	Pathways	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr20:43,880,880-43,883,205)			mRNA (may differ from genome)		Protein (132 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	Malacards	MGI	OMIM	PubMed	UniProtKB
Wikipedia	BioGrid CRISPR DB

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

MalaCards Disease Associations


	MalaCards Gene Search: SLPI Diseases sorted by gene-association score: lung disease (4), bronchitis (4), cystic fibrosis (3), mastitis (3), osteoporosis (2), vaginal disease (2), urinary tract obstruction (2), idiopathic hypercalciuria (2), ovarian cancer, somatic (1)

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D013749 Tetrachlorodibenzodioxin D004041 Dietary Fats D004054 Diethylstilbestrol D004958 Estradiol D004997 Ethinyl Estradiol D006861 Hydrogen Peroxide D015056 1-Methyl-3-isobutylxanthine C029141 2,2,5,7,8-pentamethyl-1-hydroxychroman C014211 2,3,7,8-tetrachlorodibenzofuran C010914 2,4-diaminotoluene C049584 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine C035207 4-amino-2,6-dinitrotoluene D000082 Acetaminophen D016604 Aflatoxin B1 D000643 Ammonium Chloride D001151 Arsenic D001241 Aspirin D001564 Benzo(a)pyrene D002330 Carmustine D002509 Cephaloridine D002945 Cisplatin D003300 Copper D003474 Curcumin D003520 Cyclophosphamide D016572 Cyclosporine D003907 Dexamethasone D004137 Dinitrochlorobenzene D005419 Flavonoids D019833 Genistein D005839 Gentamicins D007501 Iron C098607 JP8 aviation fuel D008070 Lipopolysaccharides D058185 Magnetite Nanoparticles C558013 NSC 689534 D010634 Phenobarbital D011374 Progesterone D012906 Smoke D053260 Soot D004113 Succimer D014028 Tobacco Smoke Pollution D014118 Toxins, Biological D014241 Trichloroethylene D014302 Trinitrobenzenesulfonic Acid C006780 bisphenol A C018021 cobaltous chloride C057862 cyanoginosin LR C000499 ferric oxide C065382 fluticasone C069837 fullerene C60 C051890 irinotecan C031721 naphthalene C474055 octylphenol C023036 perfluorooctanoic acid C006253 pirinixic acid C089730 rosiglitazone C057823 salmeterol C541923 sandostatinLAR C047246 temozolomide D020122 tert-Butylhydroperoxide C009495 titanium dioxide C015559 trimellitic anhydride C022884 undecane

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 6514.72 RPKM in Minor Salivary Gland Total median expression: 9269.01 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-0.10	21	-0.005	Picture	PostScript	Text
3' UTR	-52.20	176	-0.297	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

Pfam Domains:
PF00095 - WAP-type (Whey Acidic Protein) 'four-disulfide core'

SCOP Domains:
57256 - Elafin-like

ModBase Predicted Comparative 3D Structure on Q6LDI0


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details	Gene Details
Gene Sorter	Gene Sorter
	RGD

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0008233 peptidase activity Biological Process: GO:0006508 proteolysis

Descriptions from all associated GenBank mRNAs


	X04470 - Human mRNA for antileukoprotease (ALP) from cervix uterus. BC020708 - Homo sapiens secretory leukocyte peptidase inhibitor, mRNA (cDNA clone MGC:22479 IMAGE:4733996), complete cds. X04503 - Human SLPI mRNA fragment for secretory leucocyte protease inhibitor. AX772818 - Sequence 15 from Patent WO03046180. JD108211 - Sequence 89235 from Patent EP1572962. JD201692 - Sequence 182716 from Patent EP1572962. JD478725 - Sequence 459749 from Patent EP1572962. JD541168 - Sequence 522192 from Patent EP1572962. JD471476 - Sequence 452500 from Patent EP1572962. JD391163 - Sequence 372187 from Patent EP1572962. AF114471 - Homo sapiens secretory leukocyte proteinase inhibitor precursor, mRNA, complete cds. KJ892160 - Synthetic construct Homo sapiens clone ccsbBroadEn_01554 SLPI gene, encodes complete protein. AB464192 - Synthetic construct DNA, clone: pF1KB6712, Homo sapiens SLPI gene for secretory leukocyte peptidase inhibitor, without stop codon, in Flexi system. DQ891365 - Synthetic construct clone IMAGE:100003995; FLH176260.01X; RZPDo839B04122D secretory leukocyte peptidase inhibitor (SLPI) gene, encodes complete protein. DQ894545 - Synthetic construct Homo sapiens clone IMAGE:100009005; FLH176256.01L; RZPDo839B04121D secretory leukocyte peptidase inhibitor (SLPI) gene, encodes complete protein. AK312192 - Homo sapiens cDNA, FLJ92479, Homo sapiens secretory leukocyte protease inhibitor(antileukoproteinase) (SLPI), mRNA. JD066425 - Sequence 47449 from Patent EP1572962.

Biochemical and Signaling Pathways


	BioCarta from NCI Cancer Genome Anatomy Project h_pepiPathway - Proepithelin Conversion to Epithelin and Wound Repair Control

Other Names for This Gene


	Alternate Gene Symbols: ENST00000338380.1, NM_003064, Q6LDI0, Q6LDI0_HUMAN, SLPI , uc317vab.1, uc317vab.2 UCSC ID: ENST00000338380.2_7 RefSeq Accession: NM_003064.4 Protein: Q6LDI0

Gene Model Information


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Methods, Credits, and Use Restrictions


	Click here for details on how this gene model was made and data restrictions if any.