ID:NAC1_HUMAN DESCRIPTION: RecName: Full=Sodium/calcium exchanger 1; AltName: Full=Na(+)/Ca(2+)-exchange protein 1; Flags: Precursor; FUNCTION: Rapidly transports Ca(2+) during excitation-contraction coupling. Ca(2+) is extruded from the cell during relaxation so as to prevent overloading of intracellular stores. ENZYME REGULATION: By ATP. SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Expressed in cardiac sarcolemma, brain, kidney, liver, pancreas, skeletal muscle, placenta and lung. SIMILARITY: Belongs to the sodium/potassium/calcium exchanger family. SLC8 subfamily. SIMILARITY: Contains 2 Calx-beta domains.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P32418
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0005432 calcium:sodium antiporter activity GO:0005509 calcium ion binding GO:0005515 protein binding GO:0005516 calmodulin binding GO:0008092 cytoskeletal protein binding GO:0015297 antiporter activity GO:0030506 ankyrin binding GO:0044325 ion channel binding GO:0046872 metal ion binding GO:0099580 ion antiporter activity involved in regulation of postsynaptic membrane potential
Biological Process: GO:0001666 response to hypoxia GO:0002026 regulation of the force of heart contraction GO:0002027 regulation of heart rate GO:0002028 regulation of sodium ion transport GO:0006811 ion transport GO:0006814 sodium ion transport GO:0006816 calcium ion transport GO:0006874 cellular calcium ion homeostasis GO:0006883 cellular sodium ion homeostasis GO:0006936 muscle contraction GO:0007154 cell communication GO:0007204 positive regulation of cytosolic calcium ion concentration GO:0007584 response to nutrient GO:0009749 response to glucose GO:0010649 regulation of cell communication by electrical coupling GO:0010763 positive regulation of fibroblast migration GO:0010881 regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion GO:0010882 regulation of cardiac muscle contraction by calcium ion signaling GO:0014829 vascular smooth muscle contraction GO:0021537 telencephalon development GO:0030501 positive regulation of bone mineralization GO:0033198 response to ATP GO:0034614 cellular response to reactive oxygen species GO:0035725 sodium ion transmembrane transport GO:0035902 response to immobilization stress GO:0035994 response to muscle stretch GO:0036376 sodium ion export from cell GO:0042493 response to drug GO:0042542 response to hydrogen peroxide GO:0044557 relaxation of smooth muscle GO:0051481 negative regulation of cytosolic calcium ion concentration GO:0051924 regulation of calcium ion transport GO:0055013 cardiac muscle cell development GO:0055074 calcium ion homeostasis GO:0055085 transmembrane transport GO:0055119 relaxation of cardiac muscle GO:0060048 cardiac muscle contraction GO:0060078 regulation of postsynaptic membrane potential GO:0060401 cytosolic calcium ion transport GO:0060402 calcium ion transport into cytosol GO:0070509 calcium ion import GO:0070588 calcium ion transmembrane transport GO:0071313 cellular response to caffeine GO:0071320 cellular response to cAMP GO:0071456 cellular response to hypoxia GO:0086012 membrane depolarization during cardiac muscle cell action potential GO:0086064 cell communication by electrical coupling involved in cardiac conduction GO:0098719 sodium ion import across plasma membrane GO:0098735 positive regulation of the force of heart contraction GO:1901660 calcium ion export GO:1903779 regulation of cardiac conduction
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
