ID:SC5A3_HUMAN DESCRIPTION: RecName: Full=Sodium/myo-inositol cotransporter; Short=Na(+)/myo-inositol cotransporter; AltName: Full=Sodium/myo-inositol transporter 1; Short=SMIT1; AltName: Full=Solute carrier family 5 member 3; FUNCTION: Prevents intracellular accumulation of high concentrations of myo-inositol (an osmolyte) that result in impairment of cellular function. SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. SIMILARITY: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF00474 - Sodium:solute symporter family
ModBase Predicted Comparative 3D Structure on P53794
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006020 inositol metabolic process GO:0006811 ion transport GO:0006814 sodium ion transport GO:0007422 peripheral nervous system development GO:0015798 myo-inositol transport GO:0043576 regulation of respiratory gaseous exchange GO:0055085 transmembrane transport
AY061855 - Homo sapiens mitochondrial ribosomal protein S6 (C21orf101) mRNA, complete cds; nuclear gene for mitochondrial product. AX750578 - Sequence 4 from Patent WO0221134. AK312084 - Homo sapiens cDNA, FLJ92365, Homo sapiens mitochondrial ribosomal protein S6 (MRPS6), nuclear gene encoding mitochondrial protein, mRNA. AB049942 - Homo sapiens MRPS6 mRNA for mitochondrial ribosomal protein S6, partial cds. BC010076 - Homo sapiens mitochondrial ribosomal protein S6, mRNA (cDNA clone MGC:19576 IMAGE:4304420), complete cds. BC004976 - Homo sapiens mitochondrial ribosomal protein S6, mRNA (cDNA clone MGC:3825 IMAGE:2958115), complete cds. BC000547 - Homo sapiens mitochondrial ribosomal protein S6, mRNA (cDNA clone MGC:2037 IMAGE:3162515), complete cds. JD459250 - Sequence 440274 from Patent EP1572962. JD242332 - Sequence 223356 from Patent EP1572962. BC051302 - Homo sapiens mitochondrial ribosomal protein S6, mRNA (cDNA clone MGC:59918 IMAGE:4855355), complete cds. JD118744 - Sequence 99768 from Patent EP1572962. HQ448691 - Synthetic construct Homo sapiens clone IMAGE:100072135; CCSB006972_02 mitochondrial ribosomal protein S6 (MRPS6) gene, encodes complete protein. KJ899489 - Synthetic construct Homo sapiens clone ccsbBroadEn_08883 MRPS6 gene, encodes complete protein. AK055913 - Homo sapiens cDNA FLJ31351 fis, clone MESAN2000167. AB527215 - Synthetic construct DNA, clone: pF1KE0349, Homo sapiens SLC5A3 gene for solute carrier family 5 (sodium/myo-inositol cotransporter), member 3, without stop codon, in Flexi system. BC140349 - Synthetic construct Homo sapiens clone IMAGE:100014394, MGC:173243 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 (SLC5A3) mRNA, encodes complete protein. BC146536 - Synthetic construct Homo sapiens clone IMAGE:100014885, MGC:180153 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 (SLC5A3) mRNA, encodes complete protein. AX750579 - Sequence 5 from Patent WO0221134. AL833562 - Homo sapiens mRNA; cDNA DKFZp686J1244 (from clone DKFZp686J1244). X83558 - Homo sapiens G21VN02 mRNA. AK092248 - Homo sapiens cDNA FLJ34929 fis, clone NT2RP7004728. FW340093 - Screening. AB074183 - Homo sapiens primary neuroblastoma cDNA, clone:Nbla10457, full insert sequence. AK024896 - Homo sapiens cDNA: FLJ21243 fis, clone COL01164. AK026169 - Homo sapiens cDNA: FLJ22516 fis, clone HRC12162.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein P53794 (Reactome details) participates in the following event(s):
R-HSA-429663 SLC5A3 (SMIT1) transports myo-inositol (Ins) with Na+ from extracellular region to cytosol R-HSA-429593 Inositol transporters R-HSA-425366 Transport of bile salts and organic acids, metal ions and amine compounds R-HSA-425407 SLC-mediated transmembrane transport R-HSA-382551 Transport of small molecules
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
