Human Gene SLC39A14 (ENST00000381237.6_14) from GENCODE V47lift37
  Description: solute carrier family 39 member 14, transcript variant 10 (from RefSeq NM_001351660.2)
Gencode Transcript: ENST00000381237.6_14
Gencode Gene: ENSG00000104635.15_17
Transcript (Including UTRs)
   Position: hg19 chr8:22,224,791-22,280,249 Size: 55,459 Total Exon Count: 9 Strand: +
Coding Region
   Position: hg19 chr8:22,262,224-22,277,211 Size: 14,988 Coding Exon Count: 8 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesGeneReviewsModel Information
Methods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr8:22,224,791-22,280,249)mRNA (may differ from genome)Protein (492 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
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UniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: S39AE_HUMAN
DESCRIPTION: RecName: Full=Zinc transporter ZIP14; AltName: Full=LIV-1 subfamily of ZIP zinc transporter 4; Short=LZT-Hs4; AltName: Full=Solute carrier family 39 member 14; AltName: Full=Zrt- and Irt-like protein 14; Short=ZIP-14; Flags: Precursor;
FUNCTION: May mediate cellular uptake of nontransferrin-bound iron (By similarity). Broad-scope metal ion transporter with a preference for zinc uptake.
SUBUNIT: Homotrimer.
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein (Potential). Cell projection, lamellipodium. Note=Localized to the plasma membrane and also found colocalized with F-actin concentrated on lamellipodiae.
TISSUE SPECIFICITY: Ubiquitously expressed, with increased expression in liver, pancreas, fetal liver, thyroid gland, left and right ventricle, right atrium and fetal heart. Weakly expressed in spleen, thymus, and peripheral blood leukocytes.
SIMILARITY: Belongs to the ZIP transporter (TC 2.A.5) family.
SEQUENCE CAUTION: Sequence=BAA06685.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: SLC39A14
Diseases sorted by gene-association score: hypermanganesemia with dystonia 2* (1229), dystonia 2 (20), dystonia (13)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene
  • D015032 Zinc
  • D000082 Acetaminophen
  • D019327 Copper Sulfate
  • C044387 N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine
  • C517041 (4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II)
  • C023514 2,6-dinitrotoluene
  • C532162 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine
  • C028451 3,4,3',4'-tetrachlorobiphenyl
  • C009505 4,4'-diaminodiphenylmethane
  • C002850 4,7-diphenylphenanthroline sulfonate
          more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 156.02 RPKM in Liver
Total median expression: 878.94 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -70.40146-0.482 Picture PostScript Text
3' UTR -902.203038-0.297 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR003689 - ZIP

Pfam Domains:
PF02535 - ZIP Zinc transporter

ModBase Predicted Comparative 3D Structure on Q15043
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005384 manganese ion transmembrane transporter activity
GO:0005385 zinc ion transmembrane transporter activity
GO:0015093 ferrous iron transmembrane transporter activity
GO:0046873 metal ion transmembrane transporter activity

Biological Process:
GO:0006811 ion transport
GO:0006826 iron ion transport
GO:0006829 zinc II ion transport
GO:0006882 cellular zinc ion homeostasis
GO:0030001 metal ion transport
GO:0055085 transmembrane transport
GO:0071421 manganese ion transmembrane transport
GO:0071577 zinc II ion transmembrane transport
GO:0071578 zinc II ion transmembrane import
GO:1903874 ferrous iron transmembrane transport

Cellular Component:
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030027 lamellipodium
GO:0042995 cell projection


-  Descriptions from all associated GenBank mRNAs
  BC015770 - Homo sapiens solute carrier family 39 (zinc transporter), member 14, mRNA (cDNA clone MGC:23235 IMAGE:4865469), complete cds.
JF432188 - Synthetic construct Homo sapiens clone IMAGE:100073347 solute carrier family 39 (zinc transporter), member 14 (SLC39A14) gene, encodes complete protein.
KU178568 - Homo sapiens solute carrier family 39 member 14 isoform 1 (SLC39A14) mRNA, partial cds.
KU178569 - Homo sapiens solute carrier family 39 member 14 isoform 2 (SLC39A14) mRNA, complete cds, alternatively spliced.
KU178570 - Homo sapiens solute carrier family 39 member 14 isoform 3 (SLC39A14) mRNA, partial cds, alternatively spliced.
KU178571 - Homo sapiens solute carrier family 39 member 14 isoform 4 (SLC39A14) mRNA, complete cds, alternatively spliced.
AK172810 - Homo sapiens cDNA FLJ23971 fis, clone HEP18208.
D31887 - Homo sapiens KIAA0062 mRNA.
AK295807 - Homo sapiens cDNA FLJ52300 complete cds, highly similar to Homo sapiens solute carrier family 39 (zinc transporter), member 14 (SLC39A14), mRNA.
JD405401 - Sequence 386425 from Patent EP1572962.
AB383730 - Synthetic construct DNA, clone: pF1KSDA0062, Homo sapiens SLC39A14 gene for solute carrier family 39, member 14, complete cds, without stop codon, in Flexi system.
JD386359 - Sequence 367383 from Patent EP1572962.
CU677439 - Synthetic construct Homo sapiens gateway clone IMAGE:100019606 5' read SLC39A14 mRNA.
AK096825 - Homo sapiens cDNA FLJ39506 fis, clone PROST2017612.
AF026940 - Homo sapiens cig19 mRNA, partial sequence.
BC000068 - Homo sapiens solute carrier family 39 (zinc transporter), member 14, mRNA (cDNA clone IMAGE:3503901), partial cds.
BX648538 - Homo sapiens mRNA; cDNA DKFZp779O1626 (from clone DKFZp779O1626).
JD498169 - Sequence 479193 from Patent EP1572962.
JD204218 - Sequence 185242 from Patent EP1572962.
JD491350 - Sequence 472374 from Patent EP1572962.
JD200316 - Sequence 181340 from Patent EP1572962.
JD385086 - Sequence 366110 from Patent EP1572962.
JD259146 - Sequence 240170 from Patent EP1572962.
JD081370 - Sequence 62394 from Patent EP1572962.
JD275805 - Sequence 256829 from Patent EP1572962.
JD208990 - Sequence 190014 from Patent EP1572962.
JD188950 - Sequence 169974 from Patent EP1572962.
JD506940 - Sequence 487964 from Patent EP1572962.
JD039610 - Sequence 20634 from Patent EP1572962.
JD363741 - Sequence 344765 from Patent EP1572962.
JD046100 - Sequence 27124 from Patent EP1572962.
JD227448 - Sequence 208472 from Patent EP1572962.
JD488818 - Sequence 469842 from Patent EP1572962.
JD322041 - Sequence 303065 from Patent EP1572962.
JD360356 - Sequence 341380 from Patent EP1572962.
JD160504 - Sequence 141528 from Patent EP1572962.
JD540589 - Sequence 521613 from Patent EP1572962.
JD069129 - Sequence 50153 from Patent EP1572962.
JD536759 - Sequence 517783 from Patent EP1572962.
JD181883 - Sequence 162907 from Patent EP1572962.
JD565726 - Sequence 546750 from Patent EP1572962.
JD222019 - Sequence 203043 from Patent EP1572962.
JD108967 - Sequence 89991 from Patent EP1572962.
JD456245 - Sequence 437269 from Patent EP1572962.
JD410042 - Sequence 391066 from Patent EP1572962.
JD360494 - Sequence 341518 from Patent EP1572962.
JD507736 - Sequence 488760 from Patent EP1572962.
JD315576 - Sequence 296600 from Patent EP1572962.
JD467809 - Sequence 448833 from Patent EP1572962.
JD052435 - Sequence 33459 from Patent EP1572962.
JD258107 - Sequence 239131 from Patent EP1572962.
JD132102 - Sequence 113126 from Patent EP1572962.
JD546595 - Sequence 527619 from Patent EP1572962.
JD333667 - Sequence 314691 from Patent EP1572962.
MP015425 - Sequence 628 from Patent WO2019016252.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q15043 (Reactome details) participates in the following event(s):

R-HSA-442317 ZIP6 and ZIP14 mediate zinc influx into cells
R-HSA-442387 ZIP8 mediates zinc influx into cells
R-HSA-442380 Zinc influx into cells by the SLC39 gene family
R-HSA-435354 Zinc transporters
R-HSA-425410 Metal ion SLC transporters
R-HSA-425366 Transport of bile salts and organic acids, metal ions and amine compounds
R-HSA-425407 SLC-mediated transmembrane transport
R-HSA-382551 Transport of small molecules

-  Other Names for This Gene
  Alternate Gene Symbols: A6NH98, B4DIW3, B6EU88, D3DSR4, ENST00000381237.1, ENST00000381237.2, ENST00000381237.3, ENST00000381237.4, ENST00000381237.5, KIAA0062 , NM_001351660, Q15043, Q6ZME8, Q96BB3, S39AE_HUMAN, SLC39A14 , uc318qde.1, uc318qde.2, ZIP14
UCSC ID: ENST00000381237.6_14
RefSeq Accession: NM_001128431.4
Protein: Q15043 (aka S39AE_HUMAN)

-  GeneReviews for This Gene
  GeneReviews article(s) related to gene SLC39A14:
slc39a14-def (SLC39A14 Deficiency)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.