ID:S29A1_HUMAN DESCRIPTION: RecName: Full=Equilibrative nucleoside transporter 1; AltName: Full=Equilibrative nitrobenzylmercaptopurine riboside-sensitive nucleoside transporter; Short=Equilibrative NBMPR-sensitive nucleoside transporter; AltName: Full=Nucleoside transporter, es-type; AltName: Full=Solute carrier family 29 member 1; FUNCTION: Mediates both influx and efflux of nucleosides across the membrane (equilibrative transporter). It is sensitive (ES) to low concentrations of the inhibitor nitrobenzylmercaptopurine riboside (NBMPR) and is sodium-independent. It has a higher affinity for adenosine. Inhibited by dipyridamole and dilazep (anticancer chemotherapeutics drugs). BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=0.62 mM for adenosine; Note=Vmax for adenosine uptake is about the same for SLC29A1 and SLC29A2; INTERACTION: P49842:STK19; NbExp=1; IntAct=EBI-347907, EBI-347581; SUBCELLULAR LOCATION: Basolateral cell membrane; Multi-pass membrane protein. Apical cell membrane; Multi-pass membrane protein. Note=Predominantly localized in the basolateral membrane in polarized MDCK cells. TISSUE SPECIFICITY: Expressed in heart, brain, mammary gland, erythrocytes and placenta, and also in fetal liver and spleen. PTM: Glycosylated. SIMILARITY: Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
SCOP Domains: 103473 - MFS general substrate transporter
ModBase Predicted Comparative 3D Structure on Q99808
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
BC095398 - Homo sapiens cDNA clone IMAGE:30348758, containing frame-shift errors. AK304285 - Homo sapiens cDNA FLJ57777 complete cds, highly similar to Equilibrative nucleoside transporter 1. AK090491 - Homo sapiens cDNA FLJ33172 fis, clone ADRGL2002029, highly similar to Equilibrative nucleoside transporter 1. AX746476 - Sequence 1 from Patent EP1308459. AB490708 - Homo sapiens SLC29A1 mRNA for equilibrative nucleoside transporter 1, partial cds, clone: SLC29A1-d2/4. AX775997 - Sequence 267 from Patent WO03048202. U81375 - Human placental equilibrative nucleoside transporter 1 (hENT1) mRNA, complete cds. AF079117 - Homo sapiens equilibrative NBMPR-sensitive nucleoside transporter (ENT1) mRNA, complete cds. BC001382 - Homo sapiens solute carrier family 29 (nucleoside transporters), member 1, mRNA (cDNA clone MGC:1465 IMAGE:3051441), complete cds. AK293558 - Homo sapiens cDNA FLJ58447 complete cds, highly similar to Equilibrative nucleoside transporter 1. BC008954 - Homo sapiens solute carrier family 29 (nucleoside transporters), member 1, mRNA (cDNA clone MGC:3778 IMAGE:3010092), complete cds. AK090615 - Homo sapiens cDNA FLJ33296 fis, clone BNGH42001247, highly similar to Equilibrative nucleoside transporter 1. AB490709 - Homo sapiens SLC29A1 mRNA for equilibrative nucleoside transporter 1, partial cds, clone: SLC29A1-b2/4. JD343274 - Sequence 324298 from Patent EP1572962. DQ892133 - Synthetic construct clone IMAGE:100004763; FLH183313.01X; RZPDo839A11142D solute carrier family 29 (nucleoside transporters), member 1 (SLC29A1) gene, encodes complete protein. DQ895327 - Synthetic construct Homo sapiens clone IMAGE:100009787; FLH183309.01L; RZPDo839A11141D solute carrier family 29 (nucleoside transporters), member 1 (SLC29A1) gene, encodes complete protein. CU679195 - Synthetic construct Homo sapiens gateway clone IMAGE:100019488 5' read SLC29A1 mRNA. KJ891110 - Synthetic construct Homo sapiens clone ccsbBroadEn_00504 SLC29A1 gene, encodes complete protein. JD022989 - Sequence 4013 from Patent EP1572962. JD561757 - Sequence 542781 from Patent EP1572962. JD316629 - Sequence 297653 from Patent EP1572962. JD422797 - Sequence 403821 from Patent EP1572962. JD537056 - Sequence 518080 from Patent EP1572962. JD193925 - Sequence 174949 from Patent EP1572962. JD393686 - Sequence 374710 from Patent EP1572962. JD556648 - Sequence 537672 from Patent EP1572962. JD258061 - Sequence 239085 from Patent EP1572962. JD133152 - Sequence 114176 from Patent EP1572962. JD174467 - Sequence 155491 from Patent EP1572962. JD548273 - Sequence 529297 from Patent EP1572962. JD528010 - Sequence 509034 from Patent EP1572962. JD102283 - Sequence 83307 from Patent EP1572962. JD222184 - Sequence 203208 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q99808 (Reactome details) participates in the following event(s):
R-HSA-109534 Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1 R-HSA-109536 Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1 R-HSA-109527 Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2 R-HSA-109529 Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2 R-HSA-83936 Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane R-HSA-425397 Transport of vitamins, nucleosides, and related molecules R-HSA-425407 SLC-mediated transmembrane transport R-HSA-382551 Transport of small molecules
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
