ID:ADT1_HUMAN DESCRIPTION: RecName: Full=ADP/ATP translocase 1; AltName: Full=ADP,ATP carrier protein 1; AltName: Full=ADP,ATP carrier protein, heart/skeletal muscle isoform T1; AltName: Full=Adenine nucleotide translocator 1; Short=ANT 1; AltName: Full=Solute carrier family 25 member 4; FUNCTION: Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane. SUBUNIT: Found in a complex with ARL2, ARL2BP and SLC25A4. Interacts with ARL2BP (By similarity). Homodimer. Interacts with HIV-1 Vpr. SUBCELLULAR LOCATION: Mitochondrion inner membrane; Multi-pass membrane protein. DISEASE: Defects in SLC25A4 are a cause of progressive external ophthalmoplegia with mitochondrial DNA deletions autosomal dominant type 2 (PEOA2) [MIM:609283]. Progressive external ophthalmoplegia is characterized by progressive weakness of ocular muscles and levator muscle of the upper eyelid. In a minority of cases, it is associated with skeletal myopathy, which predominantly involves axial or proximal muscles and which causes abnormal fatigability and even permanent muscle weakness. Ragged- red fibers and atrophy are found on muscle biopsy. A large proportion of chronic ophthalmoplegias are associated with other symptoms, leading to a multisystemic pattern of this disease. Additional symptoms are variable, and may include cataracts, hearing loss, sensory axonal neuropathy, ataxia, depression, hypogonadism, and parkinsonism. MISCELLANEOUS: The transmembrane helices are not perpendicular to the plane of the membrane, but cross the membrane at an angle. Odd-numbered transmembrane helices exhibit a sharp kink, due to the presence of a conserved proline residue (By similarity). SIMILARITY: Belongs to the mitochondrial carrier family. SIMILARITY: Contains 3 Solcar repeats. WEB RESOURCE: Name=GeneReviews; URL="http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/SLC25A4";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P12235
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0000002 mitochondrial genome maintenance GO:0006091 generation of precursor metabolites and energy GO:0008637 apoptotic mitochondrial changes GO:0015853 adenine transport GO:0015866 ADP transport GO:0015867 ATP transport GO:0016032 viral process GO:0046902 regulation of mitochondrial membrane permeability GO:0050796 regulation of insulin secretion GO:0055085 transmembrane transport GO:0060546 negative regulation of necroptotic process
J02966 - Human mitochondrial ADP/ADT translocator mRNA, complete cds. AK291902 - Homo sapiens cDNA FLJ75273 complete cds, highly similar to Homo sapiens solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4, mRNA. BC063643 - Homo sapiens solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4, mRNA (cDNA clone MGC:70914 IMAGE:4708068), complete cds. BC008664 - Homo sapiens solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4, mRNA (cDNA clone MGC:9281 IMAGE:3871960), complete cds. AB209764 - Homo sapiens mRNA for solute carrier family 25 member 4 variant protein. BC061589 - Homo sapiens solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4, mRNA (cDNA clone MGC:75169 IMAGE:6195081), complete cds. J03593 - Human ADP/ATP translocase mRNA, 5' end, clone pHAT14. DQ894735 - Synthetic construct Homo sapiens clone IMAGE:100009195; FLH177938.01L; RZPDo839F08125D solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4 (SLC25A4) gene, encodes complete protein. DQ891547 - Synthetic construct clone IMAGE:100004177; FLH177942.01X; RZPDo839F08126D solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4 (SLC25A4) gene, encodes complete protein. AB464231 - Synthetic construct DNA, clone: pF1KB6366, Homo sapiens SLC25A4 gene for solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4, without stop codon, in Flexi system. KJ890673 - Synthetic construct Homo sapiens clone ccsbBroadEn_00067 SLC25A4 gene, encodes complete protein. KR709659 - Synthetic construct Homo sapiens clone CCSBHm_00004944 SLC25A4 (SLC25A4) mRNA, encodes complete protein. KR709660 - Synthetic construct Homo sapiens clone CCSBHm_00004947 SLC25A4 (SLC25A4) mRNA, encodes complete protein. KR709661 - Synthetic construct Homo sapiens clone CCSBHm_00004948 SLC25A4 (SLC25A4) mRNA, encodes complete protein. KR709662 - Synthetic construct Homo sapiens clone CCSBHm_00004949 SLC25A4 (SLC25A4) mRNA, encodes complete protein. KU177900 - Homo sapiens solute carrier family 25 member 4 isoform 1 (SLC25A4) mRNA, partial cds. KU177901 - Homo sapiens solute carrier family 25 member 4 isoform 2 (SLC25A4) mRNA, partial cds, alternatively spliced. KU177902 - Homo sapiens solute carrier family 25 member 4 isoform 3 (SLC25A4) mRNA, partial cds, alternatively spliced. JD026342 - Sequence 7366 from Patent EP1572962. JD033251 - Sequence 14275 from Patent EP1572962. JD023680 - Sequence 4704 from Patent EP1572962. JD028537 - Sequence 9561 from Patent EP1572962. JD154695 - Sequence 135719 from Patent EP1572962. JD314954 - Sequence 295978 from Patent EP1572962. JD089054 - Sequence 70078 from Patent EP1572962. JD194629 - Sequence 175653 from Patent EP1572962. JD537266 - Sequence 518290 from Patent EP1572962. JD135679 - Sequence 116703 from Patent EP1572962. JD135676 - Sequence 116700 from Patent EP1572962. JD135678 - Sequence 116702 from Patent EP1572962. JD238022 - Sequence 219046 from Patent EP1572962. JD238021 - Sequence 219045 from Patent EP1572962. AF052119 - Homo sapiens clone 23622 mRNA sequence.
Biochemical and Signaling Pathways
BioCarta from NCI Cancer Genome Anatomy Project h_etcPathway - Electron Transport Reaction in Mitochondria
Reactome (by CSHL, EBI, and GO)
Protein P12235 (Reactome details) participates in the following event(s):
R-HSA-5250209 ARL2:GTP:ARL2BP binds SLC25A4 R-HSA-180905 Association of Vpr with ANT1 R-HSA-1307803 TIMM22 inserts proteins into inner membrane R-HSA-1268022 TOMM40 complex translocates proteins from the cytosol to the mitochondrial intermembrane space R-HSA-1299481 TIMM9:TIMM10 binds hydrophobic proteins R-HSA-5672027 ARL2:GTP:ARL2BP:SLC25A4 dimer exchanges ATP for ADP across the mitochondrial inner membrane R-HSA-1955380 TIMM9:TIMM10 transfers proteins to TIMM22 R-HSA-422356 Regulation of insulin secretion R-HSA-180897 Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization R-HSA-1268020 Mitochondrial protein import R-HSA-163685 Energy Metabolism R-HSA-176033 Interactions of Vpr with host cellular proteins R-HSA-392499 Metabolism of proteins R-HSA-1430728 Metabolism R-HSA-162909 Host Interactions of HIV factors R-HSA-162906 HIV Infection R-HSA-5663205 Infectious disease R-HSA-1643685 Disease
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
