Human Gene SFXN2 (ENST00000369893.10_4) from GENCODE V47lift37

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Description: sideroflexin 2, transcript variant 1 (from RefSeq NM_178858.6)
Gencode Transcript: ENST00000369893.10_4
Gencode Gene: ENSG00000156398.13_16
Transcript (Including UTRs)
Position: hg19 chr10:104,474,393-104,503,249 Size: 28,857 Total Exon Count: 12 Strand: +
Coding Region
Position: hg19 chr10:104,486,394-104,497,519 Size: 11,126 Coding Exon Count: 11

Page Index	Sequence and Links	UniProtKB Comments	Primers	CTD	Gene Alleles
RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species	GO Annotations
mRNA Descriptions	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr10:104,474,393-104,503,249)			mRNA (may differ from genome)		Protein (322 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	MGI	OMIM	PubMed	UniProtKB	BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: SFXN2_HUMAN DESCRIPTION: RecName: Full=Sideroflexin-2; FUNCTION: Potential iron transporter. SUBCELLULAR LOCATION: Mitochondrion membrane; Multi-pass membrane protein (By similarity). SIMILARITY: Belongs to the sideroflexin family. SEQUENCE CAUTION: Sequence=BAB70993.1; Type=Erroneous initiation;

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D016604 Aflatoxin B1 D016572 Cyclosporine C495626 14-deoxy-11,12-didehydroandrographolide C029497 2,3-bis(3'-hydroxybenzyl)butyrolactone C009505 4,4'-diaminodiphenylmethane D000082 Acetaminophen D001104 Arbutin D001564 Benzo(a)pyrene D019327 Copper Sulfate D003375 Coumestrol more ... click here to view the complete list

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 4.48 RPKM in Kidney - Cortex Total median expression: 68.13 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-17.00	71	-0.239	Picture	PostScript	Text
3' UTR	-2173.90	5730	-0.379	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR004686 - Mtc

Pfam Domains:
PF03820 - Sideroflexins

ModBase Predicted Comparative 3D Structure on Q96NB2


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details			Gene Details
Gene Sorter			Gene Sorter
		Ensembl

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0015075 ion transmembrane transporter activity Biological Process: GO:0006811 ion transport GO:0034220 ion transmembrane transport GO:0055072 iron ion homeostasis GO:0055085 transmembrane transport Cellular Component: GO:0005739 mitochondrion GO:0016020 membrane GO:0016021 integral component of membrane GO:0031966 mitochondrial membrane

Descriptions from all associated GenBank mRNAs


	BC022091 - Homo sapiens sideroflexin 2, mRNA (cDNA clone MGC:4567 IMAGE:3029622), complete cds. AF462052 - Homo sapiens sideroflexin (SFXN) mRNA, complete cds. AK308246 - Homo sapiens cDNA, FLJ98194. AK055711 - Homo sapiens cDNA FLJ31149 fis, clone IMR322001491, moderately similar to Rattus norvegicus tricarboxylate carrier-like protein mRNA. JD287000 - Sequence 268024 from Patent EP1572962. DQ896103 - Synthetic construct Homo sapiens clone IMAGE:100010563; FLH190333.01L; RZPDo839H0265D sideroflexin 2 (SFXN2) gene, encodes complete protein. DQ892856 - Synthetic construct clone IMAGE:100005486; FLH190337.01X; RZPDo839H0275D sideroflexin 2 (SFXN2) gene, encodes complete protein. KJ895340 - Synthetic construct Homo sapiens clone ccsbBroadEn_04734 SFXN2 gene, encodes complete protein. JD547835 - Sequence 528859 from Patent EP1572962. JD287274 - Sequence 268298 from Patent EP1572962. JD039400 - Sequence 20424 from Patent EP1572962. JD261456 - Sequence 242480 from Patent EP1572962. JD439089 - Sequence 420113 from Patent EP1572962. JD338605 - Sequence 319629 from Patent EP1572962. JD241710 - Sequence 222734 from Patent EP1572962. JD207873 - Sequence 188897 from Patent EP1572962. JD207872 - Sequence 188896 from Patent EP1572962. JD556688 - Sequence 537712 from Patent EP1572962. JD523873 - Sequence 504897 from Patent EP1572962. JD485258 - Sequence 466282 from Patent EP1572962. JD202942 - Sequence 183966 from Patent EP1572962. JD463677 - Sequence 444701 from Patent EP1572962. JD152192 - Sequence 133216 from Patent EP1572962. JD407511 - Sequence 388535 from Patent EP1572962. JD212904 - Sequence 193928 from Patent EP1572962. JD466374 - Sequence 447398 from Patent EP1572962. JD243624 - Sequence 224648 from Patent EP1572962. JD204785 - Sequence 185809 from Patent EP1572962. JD331546 - Sequence 312570 from Patent EP1572962. JD515547 - Sequence 496571 from Patent EP1572962. JD514203 - Sequence 495227 from Patent EP1572962. JD070749 - Sequence 51773 from Patent EP1572962. JD132924 - Sequence 113948 from Patent EP1572962. JD419040 - Sequence 400064 from Patent EP1572962. JD419041 - Sequence 400065 from Patent EP1572962. JD475685 - Sequence 456709 from Patent EP1572962. JD143912 - Sequence 124936 from Patent EP1572962. JD349772 - Sequence 330796 from Patent EP1572962. JD349738 - Sequence 330762 from Patent EP1572962. JD509606 - Sequence 490630 from Patent EP1572962. JD075236 - Sequence 56260 from Patent EP1572962. JD082034 - Sequence 63058 from Patent EP1572962. JD319815 - Sequence 300839 from Patent EP1572962. JD126549 - Sequence 107573 from Patent EP1572962. JD229273 - Sequence 210297 from Patent EP1572962. JD325918 - Sequence 306942 from Patent EP1572962. JD564345 - Sequence 545369 from Patent EP1572962. JD558275 - Sequence 539299 from Patent EP1572962. JD319354 - Sequence 300378 from Patent EP1572962. JD455493 - Sequence 436517 from Patent EP1572962. JD550030 - Sequence 531054 from Patent EP1572962. JD500924 - Sequence 481948 from Patent EP1572962. JD291164 - Sequence 272188 from Patent EP1572962. JD527575 - Sequence 508599 from Patent EP1572962. JD160998 - Sequence 142022 from Patent EP1572962. JD274638 - Sequence 255662 from Patent EP1572962. JD567058 - Sequence 548082 from Patent EP1572962. JD311904 - Sequence 292928 from Patent EP1572962. JD346385 - Sequence 327409 from Patent EP1572962. JD071908 - Sequence 52932 from Patent EP1572962. JD071907 - Sequence 52931 from Patent EP1572962.

Other Names for This Gene


	Alternate Gene Symbols: ENST00000369893.1, ENST00000369893.2, ENST00000369893.3, ENST00000369893.4, ENST00000369893.5, ENST00000369893.6, ENST00000369893.7, ENST00000369893.8, ENST00000369893.9, NM_178858, Q5JSM6, Q96NB2, SFXN2 , SFXN2_HUMAN, uc318hyb.1, uc318hyb.2 UCSC ID: ENST00000369893.10_4 RefSeq Accession: NM_178858.6 Protein: Q96NB2 (aka SFXN2_HUMAN or SFX2_HUMAN)

Gene Model Information


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Methods, Credits, and Use Restrictions


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