Human Gene SFXN1 (ENST00000321442.10_4) from GENCODE V47lift37

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Description: sideroflexin 1, transcript variant 1 (from RefSeq NM_022754.7)
Gencode Transcript: ENST00000321442.10_4
Gencode Gene: ENSG00000164466.13_12
Transcript (Including UTRs)
Position: hg19 chr5:174,905,563-174,956,745 Size: 51,183 Total Exon Count: 11 Strand: +
Coding Region
Position: hg19 chr5:174,919,107-174,953,737 Size: 34,631 Coding Exon Count: 10

Page Index	Sequence and Links	UniProtKB Comments	Primers	CTD	Gene Alleles
RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species	GO Annotations
mRNA Descriptions	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr5:174,905,563-174,956,745)			mRNA (may differ from genome)		Protein (322 aa)
Gene Sorter	Genome Browser	Other Species FASTA	Gene interactions	Table Schema	AlphaFold
BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards	HGNC
MGI	OMIM	PubMed	UniProtKB	Wikipedia	BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: SFXN1_HUMAN DESCRIPTION: RecName: Full=Sideroflexin-1; AltName: Full=Tricarboxylate carrier protein; Short=TCC; FUNCTION: Might be involved in the transport of a component required for iron utilization into or out of the mitochondria. INTERACTION: O00264:PGRMC1; NbExp=1; IntAct=EBI-355861, EBI-1045534; Q15714:TSC22D1; NbExp=1; IntAct=EBI-355861, EBI-712609; SUBCELLULAR LOCATION: Mitochondrion membrane; Multi-pass membrane protein (By similarity). SIMILARITY: Belongs to the sideroflexin family. SEQUENCE CAUTION: Sequence=AAH20517.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAB14003.1; Type=Miscellaneous discrepancy; Note=Cloning artifact; Sequence=BAB14318.1; Type=Erroneous initiation; Note=Translation N-terminally extended;

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D002994 Clofibrate D000082 Acetaminophen D013749 Tetrachlorodibenzodioxin C006253 pirinixic acid C016403 2,4-dinitrotoluene C532162 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine C023035 3,4,5,3',4'-pentachlorobiphenyl D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide D000638 Amiodarone D000643 Ammonium Chloride D001553 Benzbromarone D002945 Cisplatin D002995 Clofibric Acid D003300 Copper D019327 Copper Sulfate D003375 Coumestrol D003474 Curcumin D016572 Cyclosporine D004041 Dietary Fats D004052 Diethylnitrosamine D004317 Doxorubicin D004958 Estradiol D004997 Ethinyl Estradiol D005001 Ethionine D005978 Glutathione D019259 Lamivudine C558013 NSC 689534 D037742 Nanotubes, Carbon D009853 Omeprazole D010634 Phenobarbital D011441 Propylthiouracil D013311 Streptozocin D013629 Tamoxifen D013853 Thioacetamide D014266 Trientine D014747 Vinblastine D015215 Zidovudine C006780 bisphenol A C117342 calfactant C018021 cobaltous chloride C016517 indole-3-carbinol C041786 palm oil C066340 tolcapone C015559 trimellitic anhydride C025643 vinclozolin

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 20.72 RPKM in Cells - EBV-transformed lymphocytes Total median expression: 295.88 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-37.70	89	-0.424	Picture	PostScript	Text
3' UTR	-1070.10	3008	-0.356	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR004686 - Mtc

Pfam Domains:
PF03820 - Sideroflexins

ModBase Predicted Comparative 3D Structure on Q9H9B4


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	Genome Browser	No ortholog
Gene Details	Gene Details		Gene Details	Gene Details
Gene Sorter	Gene Sorter		Gene Sorter	Gene Sorter
	RGD	Ensembl		WormBase
				Protein Sequence
				Alignment

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0015075 ion transmembrane transporter activity Biological Process: GO:0006811 ion transport GO:0006826 iron ion transport GO:0030218 erythrocyte differentiation GO:0034220 ion transmembrane transport GO:0055072 iron ion homeostasis GO:0055085 transmembrane transport Cellular Component: GO:0005739 mitochondrion GO:0016020 membrane GO:0016021 integral component of membrane GO:0031966 mitochondrial membrane

Descriptions from all associated GenBank mRNAs


	BC063241 - Homo sapiens sideroflexin 1, mRNA (cDNA clone MGC:60019 IMAGE:6187994), complete cds. BX648188 - Homo sapiens mRNA; cDNA DKFZp686K0713 (from clone DKFZp686K0713). AK022287 - Homo sapiens cDNA FLJ12225 fis, clone MAMMA1001139, weakly similar to SRE-2 PROTEIN. AK056915 - Homo sapiens cDNA FLJ32353 fis, clone PROST2007612, highly similar to Sideroflexin-1. JD421195 - Sequence 402219 from Patent EP1572962. AF327346 - Homo sapiens tricarboxylate carrier protein mRNA, complete cds. LF209793 - JP 2014500723-A/17296: Polycomb-Associated Non-Coding RNAs. AM393845 - Synthetic construct Homo sapiens clone IMAGE:100002237 for hypothetical protein (SFXN1 gene). AB528761 - Synthetic construct DNA, clone: pF1KE0183, Homo sapiens SFXN1 gene for sideroflexin 1, without stop codon, in Flexi system. CU687662 - Synthetic construct Homo sapiens gateway clone IMAGE:100021406 5' read SFXN1 mRNA. KJ895218 - Synthetic construct Homo sapiens clone ccsbBroadEn_04612 SFXN1 gene, encodes complete protein. LF331680 - JP 2014500723-A/139183: Polycomb-Associated Non-Coding RNAs. BC020517 - Homo sapiens sideroflexin 1, mRNA (cDNA clone MGC:17801 IMAGE:3888861), complete cds. LF331681 - JP 2014500723-A/139184: Polycomb-Associated Non-Coding RNAs. LF331682 - JP 2014500723-A/139185: Polycomb-Associated Non-Coding RNAs. AK022938 - Homo sapiens cDNA FLJ12876 fis, clone NT2RP2003781, moderately similar to HYPOTHETICAL 36.7 KD PROTEIN AH6.2 IN CHROMOSOME II. LF331683 - JP 2014500723-A/139186: Polycomb-Associated Non-Coding RNAs. CU676538 - Synthetic construct Homo sapiens gateway clone IMAGE:100016849 5' read SFXN1 mRNA. KJ903609 - Synthetic construct Homo sapiens clone ccsbBroadEn_13003 SFXN1 gene, encodes complete protein. LF331686 - JP 2014500723-A/139189: Polycomb-Associated Non-Coding RNAs. JD434449 - Sequence 415473 from Patent EP1572962. LF331690 - JP 2014500723-A/139193: Polycomb-Associated Non-Coding RNAs. AK025032 - Homo sapiens cDNA: FLJ21379 fis, clone COL03327. JD310885 - Sequence 291909 from Patent EP1572962. JD103847 - Sequence 84871 from Patent EP1572962. JD267171 - Sequence 248195 from Patent EP1572962. LF331691 - JP 2014500723-A/139194: Polycomb-Associated Non-Coding RNAs. LF331692 - JP 2014500723-A/139195: Polycomb-Associated Non-Coding RNAs. JD241096 - Sequence 222120 from Patent EP1572962. LF331693 - JP 2014500723-A/139196: Polycomb-Associated Non-Coding RNAs. JD155463 - Sequence 136487 from Patent EP1572962. JD519137 - Sequence 500161 from Patent EP1572962. JD489285 - Sequence 470309 from Patent EP1572962. JD260254 - Sequence 241278 from Patent EP1572962. JD420738 - Sequence 401762 from Patent EP1572962. JD161380 - Sequence 142404 from Patent EP1572962. JD227043 - Sequence 208067 from Patent EP1572962. JD415158 - Sequence 396182 from Patent EP1572962. JD415159 - Sequence 396183 from Patent EP1572962. JD381159 - Sequence 362183 from Patent EP1572962. JD362341 - Sequence 343365 from Patent EP1572962. JD222396 - Sequence 203420 from Patent EP1572962. JD081645 - Sequence 62669 from Patent EP1572962. JD081644 - Sequence 62668 from Patent EP1572962. JD313750 - Sequence 294774 from Patent EP1572962. JD504305 - Sequence 485329 from Patent EP1572962. LF331694 - JP 2014500723-A/139197: Polycomb-Associated Non-Coding RNAs. JD548906 - Sequence 529930 from Patent EP1572962. JD433619 - Sequence 414643 from Patent EP1572962. JD196117 - Sequence 177141 from Patent EP1572962. JD211547 - Sequence 192571 from Patent EP1572962. JD142533 - Sequence 123557 from Patent EP1572962. JD222878 - Sequence 203902 from Patent EP1572962. JD542633 - Sequence 523657 from Patent EP1572962. JD542635 - Sequence 523659 from Patent EP1572962. JD542634 - Sequence 523658 from Patent EP1572962. JD197938 - Sequence 178962 from Patent EP1572962. JD052841 - Sequence 33865 from Patent EP1572962. JD092872 - Sequence 73896 from Patent EP1572962. JD174637 - Sequence 155661 from Patent EP1572962. MA567257 - JP 2018138019-A/139183: Polycomb-Associated Non-Coding RNAs. MA567258 - JP 2018138019-A/139184: Polycomb-Associated Non-Coding RNAs. MA567259 - JP 2018138019-A/139185: Polycomb-Associated Non-Coding RNAs. MA567260 - JP 2018138019-A/139186: Polycomb-Associated Non-Coding RNAs. MA567263 - JP 2018138019-A/139189: Polycomb-Associated Non-Coding RNAs. MA567267 - JP 2018138019-A/139193: Polycomb-Associated Non-Coding RNAs. MA567268 - JP 2018138019-A/139194: Polycomb-Associated Non-Coding RNAs. MA567269 - JP 2018138019-A/139195: Polycomb-Associated Non-Coding RNAs. MA567270 - JP 2018138019-A/139196: Polycomb-Associated Non-Coding RNAs. MA567271 - JP 2018138019-A/139197: Polycomb-Associated Non-Coding RNAs. MA445370 - JP 2018138019-A/17296: Polycomb-Associated Non-Coding RNAs.

Other Names for This Gene


	Alternate Gene Symbols: B3KPW3, D3DQN2, ENST00000321442.1, ENST00000321442.2, ENST00000321442.3, ENST00000321442.4, ENST00000321442.5, ENST00000321442.6, ENST00000321442.7, ENST00000321442.8, ENST00000321442.9, NM_022754, Q9H9B4, Q9HA53, SFXN1 , SFXN1_HUMAN, uc317rbo.1, uc317rbo.2 UCSC ID: ENST00000321442.10_4 RefSeq Accession: NM_022754.7 Protein: Q9H9B4 (aka SFXN1_HUMAN or SFX1_HUMAN)

Gene Model Information


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Methods, Credits, and Use Restrictions


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