ID:SETD8_HUMAN DESCRIPTION: RecName: Full=N-lysine methyltransferase SETD8; EC=2.1.1.-; AltName: Full=H4-K20-HMTase SETD8; AltName: Full=Histone-lysine N-methyltransferase SETD8; EC=2.1.1.43; AltName: Full=Lysine N-methyltransferase 5A; AltName: Full=PR/SET domain-containing protein 07; Short=PR-Set7; Short=PR/SET07; AltName: Full=SET domain-containing protein 8; FUNCTION: Protein-lysine N-methyltransferase that monomethylates both histones and non-histone proteins. Specifically monomethylates 'Lys-20' of histone H4 (H4K20me1). H4K20me1 is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. Required for cell proliferation, probably by contributing to the maintenance of proper higher-order structure of DNA during mitosis. Involved in chromosome condensation and proper cytokinesis. Nucleosomes are preferred as substrate compared to free histones. Mediates monomethylation of p53/TP53 at 'Lys-382', leading to repress p53/TP53-target genes. CATALYTIC ACTIVITY: S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone]. SUBUNIT: Interacts with L3MBTL1. INTERACTION: P62805:HIST2H4B; NbExp=4; IntAct=EBI-1268946, EBI-302023; SUBCELLULAR LOCATION: Nucleus. Chromosome. Note=Specifically localizes to mitotic chromosomes. Associates with silent chromatin on euchromatic arms. Not associated with constitutive heterochromatin. DEVELOPMENTAL STAGE: Not detected during G1 phase. First detected during S through G2 phases, and peaks during mitosis (at protein level). INDUCTION: By HCFC1 C-terminal chain, independently of HCFC1 N- terminal chain. DOMAIN: Although the SET domain contains the active site of enzymatic activity, both sequences upstream and downstream of the SET domain are required for methyltransferase activity. SIMILARITY: Belongs to the histone-lysine methyltransferase family. PR/SET subfamily. SIMILARITY: Contains 1 SET domain. CAUTION: It is uncertain whether Met-1 or Met-72 is the initiator. SEQUENCE CAUTION: Sequence=AAL40879.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9NQR1
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0000122 negative regulation of transcription from RNA polymerase II promoter GO:0006325 chromatin organization GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0007049 cell cycle GO:0018026 peptidyl-lysine monomethylation GO:0032259 methylation GO:0034770 histone H4-K20 methylation GO:0034968 histone lysine methylation GO:0043516 regulation of DNA damage response, signal transduction by p53 class mediator GO:0045892 negative regulation of transcription, DNA-templated GO:0051301 cell division GO:1901796 regulation of signal transduction by p53 class mediator
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
