Human Gene SERPINB2 (ENST00000299502.9_4) from GENCODE V47lift37

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Description: serpin family B member 2, transcript variant 2 (from RefSeq NM_002575.3)
Gencode Transcript: ENST00000299502.9_4
Gencode Gene: ENSG00000197632.9_8
Transcript (Including UTRs)
Position: hg19 chr18:61,554,939-61,571,122 Size: 16,184 Total Exon Count: 8 Strand: +
Coding Region
Position: hg19 chr18:61,558,679-61,570,539 Size: 11,861 Coding Exon Count: 7

Page Index	Sequence and Links	UniProtKB Comments	Primers	MalaCards	CTD
Gene Alleles	RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species
GO Annotations	mRNA Descriptions	Pathways	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr18:61,554,939-61,571,122)			mRNA (may differ from genome)		Protein (415 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	Malacards	MGI	OMIM	PubMed	Reactome
UniProtKB	Wikipedia	BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: PAI2_HUMAN DESCRIPTION: RecName: Full=Plasminogen activator inhibitor 2; Short=PAI-2; AltName: Full=Monocyte Arg-serpin; AltName: Full=Placental plasminogen activator inhibitor; AltName: Full=Serpin B2; AltName: Full=Urokinase inhibitor; Flags: Precursor; FUNCTION: Inhibits urokinase-type plasminogen activator. The monocyte derived PAI-2 is distinct from the endothelial cell- derived PAI-1. SUBUNIT: Interacts with PSMB1. SUBCELLULAR LOCATION: Cytoplasm. Secreted, extracellular space. PTM: The signal sequence is not cleaved. SIMILARITY: Belongs to the serpin family. Ov-serpin subfamily.

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
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Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
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To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

MalaCards Disease Associations


	MalaCards Gene Search: SERPINB2 Diseases sorted by gene-association score: lipodermatosclerosis (17), gingivitis (14), placenta accreta (11), ovarian cyst (9), joint disorders (8), adult respiratory distress syndrome (7), endometrial cancer (3), preeclampsia/eclampsia 1 (1)

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D013749 Tetrachlorodibenzodioxin D001564 Benzo(a)pyrene D019256 Cadmium Chloride D008070 Lipopolysaccharides D013755 Tetradecanoylphorbol Acetate D015032 Zinc C109986 2-aminoethoxydiphenyl borate C091768 3'-methoxy-4'-nitroflavone C023035 3,4,5,3',4'-pentachlorobiphenyl C002202 4-oxoretinoic acid D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide D015127 9,10-Dimethyl-1,2-benzanthracene C412373 AG 1879 D000082 Acetaminophen D016604 Aflatoxin B1 D000643 Ammonium Chloride D016718 Arachidonic Acid D001205 Ascorbic Acid D001241 Aspirin D001554 Benzene D002117 Calcitriol D002762 Cholecalciferol D003300 Copper D019327 Copper Sulfate D003474 Curcumin D004041 Dietary Fats D004052 Diethylnitrosamine D004054 Diethylstilbestrol D004317 Doxorubicin D004391 Dust C046770 EGTA acetoxymethyl ester D004958 Estradiol D017313 Fenretinide D005472 Fluorouracil D005492 Folic Acid D005557 Formaldehyde D005944 Glucosamine D007213 Indomethacin D015474 Isotretinoin C098607 JP8 aviation fuel D008154 Lucanthone D008558 Melphalan D008713 Methimazole D016685 Mitomycin C558013 NSC 689534 D009543 Nifedipine D010100 Oxygen D017239 Paclitaxel D052638 Particulate Matter D059808 Polyphenols D011374 Progesterone D011441 Propylthiouracil D011794 Quercetin D020849 Raloxifene D012822 Silicon Dioxide D012999 Soman D013629 Tamoxifen D013759 Tetrahydrocannabinol D013792 Thalidomide D019284 Thapsigargin D014028 Tobacco Smoke Pollution D019772 Topotecan D014118 Toxins, Biological D014212 Tretinoin D001335 Vehicle Emissions D014747 Vinblastine D014750 Vincristine C103303 alitretinoin C011512 alpha-naphthoflavone C432165 anthra(1,9-cd)pyrazol-6(2H)-one C020711 beryllium sulfate C400082 bortezomib C055494 caffeic acid phenethyl ester C488369 dasatinib C014347 decitabine C070081 fulvestrant C104810 methyl arachidonylfluorophosphonate C004925 methylmercuric chloride C014707 nitrosobenzylmethylamine C025589 ochratoxin A C006253 pirinixic acid C059514 resveratrol C061133 tamibarotene D020122 tert-Butylhydroperoxide C045037 testosterone-3-carboxymethyloxime-bovine serum albumin conjugate C517826 tetrabrominated diphenyl ether 47 C009954 trilostane C034028 vanadyl sulfate

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 21.01 RPKM in Esophagus - Mucosa Total median expression: 38.48 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-9.30	75	-0.124	Picture	PostScript	Text
3' UTR	-107.10	583	-0.184	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR023795 - Protease_inhib_I4_serpin_CS
IPR015556 - Protease_inhib_serine_PAI-2
IPR023796 - Serpin_dom
IPR000215 - Serpin_fam

Pfam Domains:
PF00079 - Serpin (serine protease inhibitor)

SCOP Domains:
56574 - Serpins

Protein Data Bank (PDB) 3-D Structure
MuPIT help

1BY7 - X-ray MuPIT

1JRR - X-ray MuPIT

2ARQ - X-ray MuPIT

2ARR - X-ray MuPIT

ModBase Predicted Comparative 3D Structure on P05120


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details	Gene Details
Gene Sorter	Gene Sorter
	RGD

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0004867 serine-type endopeptidase inhibitor activity GO:0030414 peptidase inhibitor activity Biological Process: GO:0010466 negative regulation of peptidase activity GO:0010951 negative regulation of endopeptidase activity GO:0035722 interleukin-12-mediated signaling pathway GO:0042060 wound healing GO:0042730 fibrinolysis GO:0043066 negative regulation of apoptotic process Cellular Component: GO:0005576 extracellular region GO:0005615 extracellular space GO:0005737 cytoplasm GO:0005886 plasma membrane

Descriptions from all associated GenBank mRNAs


	AK313159 - Homo sapiens cDNA, FLJ93654, highly similar to Homo sapiens serpin peptidase inhibitor, clade B (ovalbumin), member 2 (SERPINB2), mRNA. BC012609 - Homo sapiens serpin peptidase inhibitor, clade B (ovalbumin), member 2, mRNA (cDNA clone MGC:13616 IMAGE:4281085), complete cds. LP895366 - Sequence 230 from Patent EP3253886. Y00630 - Human mRNA for Arg-Serpin (plasminogen activator-inhibitor 2, PAI-2). JD524593 - Sequence 505617 from Patent EP1572962. J02685 - Human placental plasminogen activator inhibitor mRNA, complete cds. A21238 - H.sapiens BTA 1445 mRNA for Pai-2. J03603 - Human plasminogen activator inhibitor mRNA, complete cds. A32415 - H.sapiens PAI-2 cDNA in pDBP1. JD324333 - Sequence 305357 from Patent EP1572962. M18082 - Human plasminogen activator inhibitor 2 (PAI-2) mRNA, complete cds. DQ656059 - Homo sapiens clone UGL299-E-A6, mRNA sequence. A21239 - H.sapiens BTA 1916 mRNA for Pai-2. A21240 - H.sapiens BTA 1922 mRNA for Pai-2. AB527561 - Synthetic construct DNA, clone: pF1KB6627, Homo sapiens SERPINB2 gene for serpin peptidase inhibitor, clade B (ovalbumin), member 2, without stop codon, in Flexi system. DQ896116 - Synthetic construct Homo sapiens clone IMAGE:100010576; FLH190436.01L; RZPDo839A0566D serpin peptidase inhibitor, clade B (ovalbumin), member 2 (SERPINB2) gene, encodes complete protein. DQ892867 - Synthetic construct clone IMAGE:100005497; FLH190440.01X; RZPDo839A0576D serpin peptidase inhibitor, clade B (ovalbumin), member 2 (SERPINB2) gene, encodes complete protein. KJ897293 - Synthetic construct Homo sapiens clone ccsbBroadEn_06687 SERPINB2 gene, encodes complete protein. A21254 - H.sapiens PAI-2 mRNA. JD024914 - Sequence 5938 from Patent EP1572962. JD030344 - Sequence 11368 from Patent EP1572962. JD300176 - Sequence 281200 from Patent EP1572962. JD565853 - Sequence 546877 from Patent EP1572962. JD349820 - Sequence 330844 from Patent EP1572962.

Biochemical and Signaling Pathways


	BioCarta from NCI Cancer Genome Anatomy Project h_fibrinolysisPathway - Fibrinolysis Pathway Reactome (by CSHL, EBI, and GO) Protein P05120 (Reactome details) participates in the following event(s): R-HSA-159001 urokinase plasminogen activator (two-chain):uPAR + plasminogen activator inhibitor 2 (PAI-2) -> PAI-2:urokinase plasminogen activator (two-chain):uPAR R-HSA-75205 Dissolution of Fibrin Clot R-HSA-8950505 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-109582 Hemostasis R-HSA-9020591 Interleukin-12 signaling R-HSA-447115 Interleukin-12 family signaling R-HSA-449147 Signaling by Interleukins R-HSA-1280215 Cytokine Signaling in Immune system R-HSA-168256 Immune System

Other Names for This Gene


	Alternate Gene Symbols: ENST00000299502.1, ENST00000299502.2, ENST00000299502.3, ENST00000299502.4, ENST00000299502.5, ENST00000299502.6, ENST00000299502.7, ENST00000299502.8, NM_002575, P05120, PAI2, PAI2_HUMAN, PLANH2, Q96E96, uc317mkc.1, uc317mkc.2 UCSC ID: ENST00000299502.9_4 RefSeq Accession: NM_002575.3 Protein: P05120 (aka PAI2_HUMAN)

Gene Model Information


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Methods, Credits, and Use Restrictions


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