ID:LYAM3_HUMAN DESCRIPTION: RecName: Full=P-selectin; AltName: Full=CD62 antigen-like family member P; AltName: Full=Granule membrane protein 140; Short=GMP-140; AltName: Full=Leukocyte-endothelial cell adhesion molecule 3; Short=LECAM3; AltName: Full=Platelet activation dependent granule-external membrane protein; Short=PADGEM; AltName: CD_antigen=CD62P; Flags: Precursor; FUNCTION: Ca(2+)-dependent receptor for myeloid cells that binds to carbohydrates on neutrophils and monocytes. Mediates the interaction of activated endothelial cells or platelets with leukocytes. The ligand recognized is sialyl-Lewis X. Mediates rapid rolling of leukocyte rolling over vascular surfaces during the initial steps in inflammation through interaction with PSGL1. SUBUNIT: Interacts with SNX17. Interacts with PSGL1/SEPL and PODXL2 and mediates neutrophil adhesion and leukocyte rolling. This interaction requires the sialyl-Lewis X epitope of PSGL1 and PODXL2, and specific tyrosine sulfation on PSGL1. SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein. TISSUE SPECIFICITY: Stored in the alpha-granules of platelets and Weibel-Palade bodies of endothelial cells. Upon cell activation by agonists, P-selectin is transported rapidly to the cell surface. DISEASE: Defects in SELP may be a cause of susceptibility to ischemic stroke (ISCHSTR) [MIM:601367]; also known as cerebrovascular accident or cerebral infarction. A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors. SIMILARITY: Belongs to the selectin/LECAM family. SIMILARITY: Contains 1 C-type lectin domain. SIMILARITY: Contains 1 EGF-like domain. SIMILARITY: Contains 9 Sushi (CCP/SCR) domains. WEB RESOURCE: Name=SeattleSNPs; URL="http://pga.gs.washington.edu/data/selp/"; WEB RESOURCE: Name=Functional Glycomics Gateway - Glycan Binding; Note=P-selectin; URL="http://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Ctlect_354";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P16109
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
