ID:LYAM1_HUMAN DESCRIPTION: RecName: Full=L-selectin; AltName: Full=CD62 antigen-like family member L; AltName: Full=Leukocyte adhesion molecule 1; Short=LAM-1; AltName: Full=Leukocyte surface antigen Leu-8; AltName: Full=Leukocyte-endothelial cell adhesion molecule 1; Short=LECAM1; AltName: Full=Lymph node homing receptor; AltName: Full=TQ1; AltName: Full=gp90-MEL; AltName: CD_antigen=CD62L; Flags: Precursor; FUNCTION: Cell surface adhesion protein. Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia. SUBUNIT: Interaction with PSGL1/SELPLG and PODXL2 is required for promoting recruitment and rolling of leukocytes. This interaction is dependent on the sialyl Lewis X glycan modification of PSGL1 and PODXL2, and tyrosine sulfation modifications of PSGL1. Sulfation on 'Tyr-51' of PSGL1 is important for L-selectin binding. SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein. TISSUE SPECIFICITY: Expressed in B-cell lines and T-lymphocytes. SIMILARITY: Belongs to the selectin/LECAM family. SIMILARITY: Contains 1 C-type lectin domain. SIMILARITY: Contains 1 EGF-like domain. SIMILARITY: Contains 2 Sushi (CCP/SCR) domains. SEQUENCE CAUTION: Sequence=CAA34203.1; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=CAB43536.1; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=CAB43537.1; Type=Erroneous initiation; Note=Translation N-terminally shortened; WEB RESOURCE: Name=SeattleSNPs; URL="http://pga.gs.washington.edu/data/sell/"; WEB RESOURCE: Name=Functional Glycomics Gateway - Glycan Binding; Note=L-selectin; URL="http://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Ctlect_234";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P14151
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
