Human Gene SELE (ENST00000333360.12_9) from GENCODE V47lift37
  Description: selectin E (from RefSeq NM_000450.2)
Gencode Transcript: ENST00000333360.12_9
Gencode Gene: ENSG00000007908.16_12
Transcript (Including UTRs)
   Position: hg19 chr1:169,691,781-169,703,220 Size: 11,440 Total Exon Count: 14 Strand: -
Coding Region
   Position: hg19 chr1:169,694,885-169,702,753 Size: 7,869 Coding Exon Count: 12 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:169,691,781-169,703,220)mRNA (may differ from genome)Protein (610 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedReactome
UniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: LYAM2_HUMAN
DESCRIPTION: RecName: Full=E-selectin; AltName: Full=CD62 antigen-like family member E; AltName: Full=Endothelial leukocyte adhesion molecule 1; Short=ELAM-1; AltName: Full=Leukocyte-endothelial cell adhesion molecule 2; Short=LECAM2; AltName: CD_antigen=CD62E; Flags: Precursor;
FUNCTION: Cell-surface glycoprotein having a role in immunoadhesion. Mediates in the adhesion of blood neutrophils in cytokine-activated endothelium through interaction with PSGL1/SELPLG. May have a role in capillary morphogenesis.
SUBUNIT: Interacts with PSGL1/SELPLG and PODXL2 through the sialyl Lewis X epitope. PSGL1 sulfation appears not to be required for this interaction.
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
POLYMORPHISM: A polymorphism in position 149 is associated with a higher risk of coronary artery disease (CAD). A significantly higher mutation frequency (Arg-149) is observed in patients with angiographically proven severe atherosclerosis compared with an unselected population (Ser-149).
SIMILARITY: Belongs to the selectin/LECAM family.
SIMILARITY: Contains 1 C-type lectin domain.
SIMILARITY: Contains 1 EGF-like domain.
SIMILARITY: Contains 6 Sushi (CCP/SCR) domains.
WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/SELEID42247ch1q22.html";
WEB RESOURCE: Name=SeattleSNPs; URL="http://pga.gs.washington.edu/data/sele/";
WEB RESOURCE: Name=Functional Glycomics Gateway - Glycan Binding; Note=E-selectin; URL="http://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Ctlect_233";

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: SELE
Diseases sorted by gene-association score: atherosclerosis (75), rheumatoid vasculitis (23), boutonneuse fever (21), coarctation of aorta (18), leukocyte adhesion deficiency (15), afferent loop syndrome (15), heterophyiasis (14), peripheral vascular disease (14), vasculitis (13), cutaneous lupus erythematosus (13), african tick-bite fever (13), kawasaki disease (12), artery disease (12), systemic scleroderma (12), ovarian cystadenoma (12), allergic contact dermatitis (11), mooren's ulcer (11), coronary artery disease (11), malaria (10), buerger disease (10), plasmodium falciparum malaria (9), endophthalmitis (9), lymphocytic vasculitis (9), wegener granulomatosis (9), plummer's disease (8), polyarteritis nodosa (8), cytomegalovirus infection (8), vascular disease (8), arteriovenous fistula (7), ovarian benign neoplasm (7), actinic prurigo (7), fascioliasis (7), antiphospholipid syndrome (7), plague (7), hydrocele (7), subendocardial myocardial infarction (7), psoriatic arthritis (7), chronic active epstein-barr virus infection (7), takayasu arteritis (7), urticaria (7), plasmodium vivax malaria (7), funisitis (7), cardiovascular disease risk factor ) (6), localized scleroderma (6), leukostasis (6), scleritis (6), diabetic angiopathy (6), legg-calve-perthes disease (6), synovitis (6), contact dermatitis (6), endometritis (6), carotid artery disease (6), hymenolepiasis (5), shwartzman phenomenon (5), autoinflammation, lipodystrophy, and dermatosis syndrome (5), retinitis pigmentosa 60 (5), hypersensitivity reaction type iii disease (5), critical illness polyneuropathy (5), neurodegeneration with brain iron accumulation 4 (4), pustulosis palmaris et plantaris (4), hydronephrosis (4), griscelli syndrome, type 1 (4), vertebrobasilar insufficiency (4), thrombotic thrombocytopenic purpura, acquired (4), behcet syndrome (3), asthma (3), arteriosclerosis (3), colorectal cancer (3), systemic lupus erythematosus (2), cerebrovascular disease (2), diabetes mellitus, noninsulin-dependent (2), diabetes mellitus, insulin-dependent (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 16.46 RPKM in Fallopian Tube
Total median expression: 65.37 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -34.50157-0.220 Picture PostScript Text
3' UTR -450.701885-0.239 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001304 - C-type_lectin
IPR016186 - C-type_lectin-like
IPR018378 - C-type_lectin_CS
IPR016187 - C-type_lectin_fold
IPR016060 - Complement_control_module
IPR000742 - EG-like_dom
IPR013032 - EGF-like_CS
IPR002396 - Selectin_superfamily
IPR000436 - Sushi_SCR_CCP

Pfam Domains:
PF00008 - EGF-like domain
PF00059 - Lectin C-type domain
PF00084 - Sushi repeat (SCR repeat)
PF12661 - Human growth factor-like EGF

SCOP Domains:
56436 - C-type lectin-like
57535 - Complement control module/SCR domain
57196 - EGF/Laminin
57184 - Growth factor receptor domain

Protein Data Bank (PDB) 3-D Structure
MuPIT help
1ESL - X-ray MuPIT 1G1T - X-ray MuPIT 1KJA - Model


ModBase Predicted Comparative 3D Structure on P16581
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004888 transmembrane signaling receptor activity
GO:0005515 protein binding
GO:0030246 carbohydrate binding
GO:0033691 sialic acid binding
GO:0043274 phospholipase binding
GO:0046872 metal ion binding
GO:0070492 oligosaccharide binding

Biological Process:
GO:0002092 positive regulation of receptor internalization
GO:0002523 leukocyte migration involved in inflammatory response
GO:0006954 inflammatory response
GO:0007155 cell adhesion
GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
GO:0007159 leukocyte cell-cell adhesion
GO:0007202 activation of phospholipase C activity
GO:0019722 calcium-mediated signaling
GO:0030029 actin filament-based process
GO:0032496 response to lipopolysaccharide
GO:0034612 response to tumor necrosis factor
GO:0050727 regulation of inflammatory response
GO:0050900 leukocyte migration
GO:0050901 leukocyte tethering or rolling
GO:0070555 response to interleukin-1

Cellular Component:
GO:0005615 extracellular space
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005901 caveola
GO:0005905 clathrin-coated pit
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030863 cortical cytoskeleton
GO:0045121 membrane raft
GO:0048471 perinuclear region of cytoplasm


-  Descriptions from all associated GenBank mRNAs
  BC142677 - Homo sapiens selectin E, mRNA (cDNA clone MGC:164950 IMAGE:40148214), complete cds.
BC142711 - Homo sapiens selectin E, mRNA (cDNA clone MGC:165055 IMAGE:40148829), complete cds.
M24736 - Human endothelial leukocyte adhesion molecule 1 (ELAM-1) mRNA, complete cds.
M30640 - Human endothelial leukocyte adhesion molecule I (ELAM1) mRNA, complete cds.
JD049909 - Sequence 30933 from Patent EP1572962.
JD305263 - Sequence 286287 from Patent EP1572962.
JD302190 - Sequence 283214 from Patent EP1572962.
JD433787 - Sequence 414811 from Patent EP1572962.
JD552650 - Sequence 533674 from Patent EP1572962.
JD521992 - Sequence 503016 from Patent EP1572962.
BC131551 - Homo sapiens selectin E, mRNA (cDNA clone MGC:148047 IMAGE:40085183), complete cds.
JD409174 - Sequence 390198 from Patent EP1572962.
JD409173 - Sequence 390197 from Patent EP1572962.
AK314214 - Homo sapiens cDNA, FLJ94947, highly similar to Homo sapiens selectin E (endothelial adhesion molecule 1) (SELE), mRNA.
KJ892123 - Synthetic construct Homo sapiens clone ccsbBroadEn_01517 SELE gene, encodes complete protein.
KR711901 - Synthetic construct Homo sapiens clone CCSBHm_00031897 SELE (SELE) mRNA, encodes complete protein.
KR711902 - Synthetic construct Homo sapiens clone CCSBHm_00031898 SELE (SELE) mRNA, encodes complete protein.
KR711903 - Synthetic construct Homo sapiens clone CCSBHm_00031899 SELE (SELE) mRNA, encodes complete protein.
AB590624 - Synthetic construct DNA, clone: pFN21AE2027, Homo sapiens SELE gene for selectin E, without stop codon, in Flexi system.
AY367062 - Homo sapiens E-selectin mRNA, partial cds.
JD134011 - Sequence 115035 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  BioCarta from NCI Cancer Genome Anatomy Project
h_monocytePathway - Monocyte and its Surface Molecules
h_neutrophilPathway - Neutrophil and Its Surface Molecules
h_lymphocytePathway - Adhesion Molecules on Lymphocyte

Reactome (by CSHL, EBI, and GO)

Protein P16581 (Reactome details) participates in the following event(s):

R-HSA-2870221 E-selectin binds E-selectin ligand
R-HSA-202724 P-selectin binds P-selectin ligand
R-HSA-202733 Cell surface interactions at the vascular wall
R-HSA-109582 Hemostasis

-  Other Names for This Gene
  Alternate Gene Symbols: A2RRD6, ELAM1, ENST00000333360.1, ENST00000333360.10, ENST00000333360.11, ENST00000333360.2, ENST00000333360.3, ENST00000333360.4, ENST00000333360.5, ENST00000333360.6, ENST00000333360.7, ENST00000333360.8, ENST00000333360.9, LYAM2_HUMAN, NM_000450, P16111, P16581, uc317tqs.1, uc317tqs.2
UCSC ID: ENST00000333360.12_9
RefSeq Accession: NM_000450.2
Protein: P16581 (aka LYAM2_HUMAN or LEM2_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.