ID:S61A1_HUMAN DESCRIPTION: RecName: Full=Protein transport protein Sec61 subunit alpha isoform 1; Short=Sec61 alpha-1; FUNCTION: Plays a crucial role in the insertion of secretory and membrane polypeptides into the ER. Required for assembly of membrane and secretory proteins. Tightly associated with membrane- bound ribosomes, either directly or through adapter proteins. SUBUNIT: Heterotrimeric complex composed of SEC61-alpha, SEC61- beta and SEC61-gamma. SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Multi-pass membrane protein. SIMILARITY: Belongs to the SecY/SEC61-alpha family. SEQUENCE CAUTION: Sequence=BAC11283.1; Type=Erroneous initiation; Sequence=BAC11434.1; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P61619
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006613 cotranslational protein targeting to membrane GO:0006614 SRP-dependent cotranslational protein targeting to membrane GO:0006620 posttranslational protein targeting to membrane GO:0007029 endoplasmic reticulum organization GO:0015031 protein transport GO:0034341 response to interferon-gamma GO:0039019 pronephric nephron development GO:0045047 protein targeting to ER
AK299118 - Homo sapiens cDNA FLJ59739 complete cds, highly similar to Protein transport protein Sec61 subunit alpha isoform 1. AK027423 - Homo sapiens cDNA FLJ14517 fis, clone NT2RM1000833, highly similar to Protein transport protein Sec61 subunit alpha isoform 1. AK074706 - Homo sapiens cDNA FLJ90225 fis, clone NT2RM1000855, highly similar to Protein transport protein Sec61 subunit alpha isoform 1. JD228744 - Sequence 209768 from Patent EP1572962. JD259323 - Sequence 240347 from Patent EP1572962. AL832821 - Homo sapiens mRNA; cDNA DKFZp667E1224 (from clone DKFZp667E1224). BC002951 - Homo sapiens cDNA clone IMAGE:3510682. AF077032 - Homo sapiens sec61 homolog mRNA, complete cds. AF084458 - Homo sapiens sec61 homolog mRNA, complete cds. JD462948 - Sequence 443972 from Patent EP1572962. AF346602 - Homo sapiens Sec61 alpha form 1 mRNA, complete cds. AB528869 - Synthetic construct DNA, clone: pF1KE0592, Homo sapiens SEC61A1 gene for Sec61 alpha 1 subunit, without stop codon, in Flexi system. AK074928 - Homo sapiens cDNA FLJ90447 fis, clone NT2RP3001240, highly similar to Canis familiaris sec61 homologue mRNA. BC156688 - Synthetic construct Homo sapiens clone IMAGE:100062204, MGC:190200 Sec61 alpha 1 subunit (S. cerevisiae) (SEC61A1) mRNA, encodes complete protein. BC152927 - Synthetic construct Homo sapiens clone IMAGE:100016193, MGC:184194 Sec61 alpha 1 subunit (S. cerevisiae) (SEC61A1) mRNA, encodes complete protein. KJ902518 - Synthetic construct Homo sapiens clone ccsbBroadEn_11912 SEC61A1 gene, encodes complete protein. AL831940 - Homo sapiens mRNA; cDNA DKFZp313F1012 (from clone DKFZp313F1012). AK001689 - Homo sapiens cDNA FLJ10827 fis, clone NT2RP4001117, highly similar to Protein transport protein Sec61 subunit alpha isoform 1. AK075148 - Homo sapiens cDNA FLJ90667 fis, clone PLACE1005410, highly similar to Protein transport protein Sec61 alpha subunitisoform 1. AK074907 - Homo sapiens cDNA FLJ90426 fis, clone NT2RP3000460, highly similar to Protein transport protein Sec61 alpha subunitisoform 1. AK027452 - Homo sapiens cDNA FLJ14546 fis, clone NT2RM2001613, highly similar to Protein transport protein Sec61 subunit alpha isoform 1. AK027454 - Homo sapiens cDNA FLJ14548 fis, clone NT2RM2001648, highly similar to Protein transport protein Sec61 subunit alpha isoform 1. AK027458 - Homo sapiens cDNA FLJ14552 fis, clone NT2RM2001760, highly similar to Protein transport protein Sec61 subunit alpha isoform 1. AK297239 - Homo sapiens cDNA FLJ60021 complete cds, moderately similar to Protein transport protein Sec61 subunit alpha isoform 1. AK129816 - Homo sapiens cDNA FLJ26305 fis, clone DMC07965. JD566798 - Sequence 547822 from Patent EP1572962. JD300567 - Sequence 281591 from Patent EP1572962. JD564905 - Sequence 545929 from Patent EP1572962. JD534653 - Sequence 515677 from Patent EP1572962. JD061399 - Sequence 42423 from Patent EP1572962. JD469967 - Sequence 450991 from Patent EP1572962. JD288716 - Sequence 269740 from Patent EP1572962. JD386820 - Sequence 367844 from Patent EP1572962. JD102573 - Sequence 83597 from Patent EP1572962. JD543633 - Sequence 524657 from Patent EP1572962. JD550833 - Sequence 531857 from Patent EP1572962. JD465429 - Sequence 446453 from Patent EP1572962. JD188797 - Sequence 169821 from Patent EP1572962. JD380792 - Sequence 361816 from Patent EP1572962. JD337344 - Sequence 318368 from Patent EP1572962. JD182589 - Sequence 163613 from Patent EP1572962. JD437670 - Sequence 418694 from Patent EP1572962. JD442162 - Sequence 423186 from Patent EP1572962. JD512022 - Sequence 493046 from Patent EP1572962. JD467415 - Sequence 448439 from Patent EP1572962. JD236707 - Sequence 217731 from Patent EP1572962. JD370376 - Sequence 351400 from Patent EP1572962. JD369871 - Sequence 350895 from Patent EP1572962. JD431950 - Sequence 412974 from Patent EP1572962. JD334727 - Sequence 315751 from Patent EP1572962. JD141057 - Sequence 122081 from Patent EP1572962. JD136864 - Sequence 117888 from Patent EP1572962. JD485691 - Sequence 466715 from Patent EP1572962. JD218187 - Sequence 199211 from Patent EP1572962. JD117863 - Sequence 98887 from Patent EP1572962. JD372166 - Sequence 353190 from Patent EP1572962. JD546651 - Sequence 527675 from Patent EP1572962. BC029970 - Homo sapiens Sec61 alpha 1 subunit (S. cerevisiae), mRNA (cDNA clone IMAGE:4474638).
Biochemical and Signaling Pathways
BioCarta from NCI Cancer Genome Anatomy Project h_eradPathway - ER¿associated degradation (ERAD) Pathway
Reactome (by CSHL, EBI, and GO)
Protein P61619 (Reactome details) participates in the following event(s):
R-HSA-1799326 Signal-containing nascent peptide translocates to endoplasmic reticulum R-HSA-1236947 Egress of internalized antigen to the cytosol via sec61 R-HSA-5250579 ASNA1 transports TA proteins from cytosol to ER membrane R-HSA-1799329 Signal peptidase hydrolyzes signal peptide from ribosome-associated nascent protein R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane R-HSA-1236974 ER-Phagosome pathway R-HSA-381038 XBP1(S) activates chaperone genes R-HSA-72766 Translation R-HSA-1236975 Antigen processing-Cross presentation R-HSA-381070 IRE1alpha activates chaperones R-HSA-392499 Metabolism of proteins R-HSA-983169 Class I MHC mediated antigen processing & presentation R-HSA-381119 Unfolded Protein Response (UPR) R-HSA-1280218 Adaptive Immune System R-HSA-168256 Immune System
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
