Human Gene SDCBP2 (ENST00000360779.4_10) from GENCODE V47lift37
  Description: FKBP1A-SDCBP2 readthrough (NMD candidate) (from RefSeq NR_037661.1)
Gencode Transcript: ENST00000360779.4_10
Gencode Gene: ENSG00000125775.15_13
Transcript (Including UTRs)
   Position: hg19 chr20:1,290,553-1,309,783 Size: 19,231 Total Exon Count: 9 Strand: -
Coding Region
   Position: hg19 chr20:1,291,085-1,301,060 Size: 9,976 Coding Exon Count: 8 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr20:1,290,553-1,309,783)mRNA (may differ from genome)Protein (292 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMGIPubMedUniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: SDCB2_HUMAN
DESCRIPTION: RecName: Full=Syntenin-2; AltName: Full=Syndecan-binding protein 2;
SUBUNIT: Monomer and homodimer. Interacts with SDCBP (By similarity).
SIMILARITY: Contains 2 PDZ (DHR) domains.
SEQUENCE CAUTION: Sequence=AAH02727.2; Type=Erroneous initiation;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 61.10 RPKM in Esophagus - Mucosa
Total median expression: 462.83 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -23.5074-0.318 Picture PostScript Text
3' UTR -188.90532-0.355 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001478 - PDZ

Pfam Domains:
PF00595 - PDZ domain
PF17820 - PDZ domain

SCOP Domains:
50156 - PDZ domain-like

ModBase Predicted Comparative 3D Structure on Q9H190
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding
GO:0005546 phosphatidylinositol-4,5-bisphosphate binding
GO:0008022 protein C-terminus binding
GO:0008289 lipid binding
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0046982 protein heterodimerization activity

Biological Process:
GO:0007399 nervous system development
GO:0008283 cell proliferation
GO:0035556 intracellular signal transduction
GO:0046907 intracellular transport

Cellular Component:
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016607 nuclear speck
GO:0070062 extracellular exosome


-  Descriptions from all associated GenBank mRNAs
  AK309026 - Homo sapiens cDNA, FLJ99067.
AF131809 - Homo sapiens clone 24904 mRNA sequence, complete cds.
AF159228 - Homo sapiens PDZ protein SITAC18 (SITAC18) mRNA, complete cds.
BC002727 - Homo sapiens syndecan binding protein (syntenin) 2, mRNA (cDNA clone MGC:3734 IMAGE:3633262), complete cds.
JD236815 - Sequence 217839 from Patent EP1572962.
JD459860 - Sequence 440884 from Patent EP1572962.
JD399095 - Sequence 380119 from Patent EP1572962.
JD450046 - Sequence 431070 from Patent EP1572962.
AJ292245 - Homo sapiens mRNA for syntenin-2beta (syntenin-2 gene).
AJ292244 - Homo sapiens mRNA for syntenin-2alpha (syntenin-2 gene).
JD421072 - Sequence 402096 from Patent EP1572962.
KJ898662 - Synthetic construct Homo sapiens clone ccsbBroadEn_08056 SDCBP2 gene, encodes complete protein.
AB464263 - Synthetic construct DNA, clone: pF1KB3561, Homo sapiens SDCBP2 gene for syndecan binding protein (syntenin) 2, without stop codon, in Flexi system.
AK022318 - Homo sapiens cDNA FLJ12256 fis, clone MAMMA1001487.
AK296577 - Homo sapiens cDNA FLJ58991 complete cds, highly similar to Syntenin-2.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000360779.1, ENST00000360779.2, ENST00000360779.3, NR_037661, O95892, Q5W0X1, Q9BZ42, Q9H190, Q9H567, Q9NRY8, SDCB2_HUMAN, SDCBP2 , SITAC18, uc318bsk.1, uc318bsk.2
UCSC ID: ENST00000360779.4_10
RefSeq Accession: NM_080489.5
Protein: Q9H190 (aka SDCB2_HUMAN or SDB2_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.