ID:SCN3A_HUMAN DESCRIPTION: RecName: Full=Sodium channel protein type 3 subunit alpha; AltName: Full=Sodium channel protein brain III subunit alpha; AltName: Full=Sodium channel protein type III subunit alpha; AltName: Full=Voltage-gated sodium channel subtype III; AltName: Full=Voltage-gated sodium channel subunit alpha Nav1.3; FUNCTION: Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. SUBUNIT: The sodium channel consists of a large polypeptide and 2- 3 smaller ones. This sequence represents a large polypeptide. Interacts with NEDD4L. SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. DOMAIN: The sequence contains 4 internal repeats, each with 5 hydrophobic segments (S1,S2,S3,S5,S6) and one positively charged segment (S4). Segments S4 are probably the voltage-sensors and are characterized by a series of positively charged amino acids at every third position. PTM: May be ubiquitinated by NEDD4L; which would promote its endocytosis. SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family. Nav1.3/SCN3A subfamily. SIMILARITY: Contains 1 IQ domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF00520 - Ion transport protein PF06512 - Sodium ion transport-associated PF08016 - Polycystin cation channel PF11933 - Cytoplasmic domain of voltage-gated Na+ ion channel
ModBase Predicted Comparative 3D Structure on Q9NY46
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0005216 ion channel activity GO:0005244 voltage-gated ion channel activity GO:0005248 voltage-gated sodium channel activity GO:0005272 sodium channel activity
Biological Process: GO:0006811 ion transport GO:0006814 sodium ion transport GO:0019228 neuronal action potential GO:0034220 ion transmembrane transport GO:0034765 regulation of ion transmembrane transport GO:0035725 sodium ion transmembrane transport GO:0055085 transmembrane transport GO:0086010 membrane depolarization during action potential
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
