Human Gene SCARA3 (ENST00000301904.4_4) from GENCODE V47lift37

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Description: scavenger receptor class A member 3, transcript variant 1 (from RefSeq NM_016240.3)
Gencode Transcript: ENST00000301904.4_4
Gencode Gene: ENSG00000168077.14_7
Transcript (Including UTRs)
Position: hg19 chr8:27,491,419-27,530,535 Size: 39,117 Total Exon Count: 6 Strand: +
Coding Region
Position: hg19 chr8:27,491,718-27,528,868 Size: 37,151 Coding Exon Count: 6

Page Index	Sequence and Links	UniProtKB Comments	Primers	CTD	Gene Alleles
RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species	GO Annotations
mRNA Descriptions	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr8:27,491,419-27,530,535)			mRNA (may differ from genome)		Protein (606 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	MGI	OMIM	PubMed	UniProtKB	BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: SCAR3_HUMAN DESCRIPTION: RecName: Full=Scavenger receptor class A member 3; AltName: Full=Cellular stress response gene protein; FUNCTION: Seems to protect cells by scavenging oxidative molecules or harmful products of oxidation. SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Single-pass type II membrane protein. Golgi apparatus membrane; Single-pass type II membrane protein. Note=Endoplasmic reticulum and/or Golgi. TISSUE SPECIFICITY: Expressed ubiquitously. SIMILARITY: Contains 2 collagen-like domains. WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/scara3/";

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide D000082 Acetaminophen D002117 Calcitriol D002794 Choline D003300 Copper D004041 Dietary Fats D005492 Folic Acid D007649 Ketamine D008715 Methionine D018817 N-Methyl-3,4-methylenedioxyamphetamine more ... click here to view the complete list

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 57.14 RPKM in Uterus Total median expression: 835.24 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-175.70	299	-0.588	Picture	PostScript	Text
3' UTR	-626.20	1667	-0.376	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR008160 - Collagen

Pfam Domains:
PF01391 - Collagen triple helix repeat (20 copies)

SCOP Domains:
90257 - Myosin rod fragments
103652 - G protein-binding domain
57997 - Tropomyosin
58104 - Methyl-accepting chemotaxis protein (MCP) signaling domain

ModBase Predicted Comparative 3D Structure on Q6AZY7


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details	Gene Details
Gene Sorter	Gene Sorter
	RGD	Ensembl

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0005044 scavenger receptor activity GO:0005515 protein binding Biological Process: GO:0006898 receptor-mediated endocytosis GO:0006979 response to oxidative stress GO:0009650 UV protection GO:0034138 toll-like receptor 3 signaling pathway Cellular Component: GO:0000139 Golgi membrane GO:0005581 collagen trimer GO:0005783 endoplasmic reticulum GO:0005789 endoplasmic reticulum membrane GO:0005794 Golgi apparatus GO:0016020 membrane GO:0016021 integral component of membrane

Descriptions from all associated GenBank mRNAs


	BC060811 - Homo sapiens scavenger receptor class A, member 3, mRNA (cDNA clone MGC:71653 IMAGE:30335021), complete cds. AB007829 - Homo sapiens mRNA for CSR1, complete cds. AB007830 - Homo sapiens mRNA for CSR2, complete cds. BC075067 - Homo sapiens scavenger receptor class A, member 3, mRNA (cDNA clone MGC:103971 IMAGE:30915376), complete cds. BC075068 - Homo sapiens scavenger receptor class A, member 3, mRNA (cDNA clone MGC:104133 IMAGE:30915589), complete cds. AB587561 - Synthetic construct DNA, clone: pF1KE1097, Homo sapiens SCARA3 gene for scavenger receptor class A, member 3, without stop codon, in Flexi system. HQ448486 - Synthetic construct Homo sapiens clone IMAGE:100071918; CCSB010769_01 scavenger receptor class A, member 3 (SCARA3) gene, encodes complete protein. KJ893912 - Synthetic construct Homo sapiens clone ccsbBroadEn_03306 SCARA3 gene, encodes complete protein. JD458371 - Sequence 439395 from Patent EP1572962. JD464103 - Sequence 445127 from Patent EP1572962. JD069280 - Sequence 50304 from Patent EP1572962. JD254893 - Sequence 235917 from Patent EP1572962. CU687438 - Synthetic construct Homo sapiens gateway clone IMAGE:100020926 5' read SCARA3 mRNA. JD281311 - Sequence 262335 from Patent EP1572962. JD102952 - Sequence 83976 from Patent EP1572962. JD064841 - Sequence 45865 from Patent EP1572962. JD085626 - Sequence 66650 from Patent EP1572962. JD156317 - Sequence 137341 from Patent EP1572962. JD202887 - Sequence 183911 from Patent EP1572962. JD112798 - Sequence 93822 from Patent EP1572962. JD534225 - Sequence 515249 from Patent EP1572962. JD097353 - Sequence 78377 from Patent EP1572962. JD377913 - Sequence 358937 from Patent EP1572962. JD353905 - Sequence 334929 from Patent EP1572962. JD377827 - Sequence 358851 from Patent EP1572962. JD534224 - Sequence 515248 from Patent EP1572962. JD050673 - Sequence 31697 from Patent EP1572962. JD363758 - Sequence 344782 from Patent EP1572962. JD110153 - Sequence 91177 from Patent EP1572962. JD504706 - Sequence 485730 from Patent EP1572962. JD451288 - Sequence 432312 from Patent EP1572962. JD098958 - Sequence 79982 from Patent EP1572962. JD110147 - Sequence 91171 from Patent EP1572962. JD504634 - Sequence 485658 from Patent EP1572962. JD353907 - Sequence 334931 from Patent EP1572962. JD534239 - Sequence 515263 from Patent EP1572962. JD083430 - Sequence 64454 from Patent EP1572962. JD110712 - Sequence 91736 from Patent EP1572962. JD089071 - Sequence 70095 from Patent EP1572962. JD534663 - Sequence 515687 from Patent EP1572962. JD139710 - Sequence 120734 from Patent EP1572962. JD097129 - Sequence 78153 from Patent EP1572962. JD098962 - Sequence 79986 from Patent EP1572962. JD051426 - Sequence 32450 from Patent EP1572962. JD098954 - Sequence 79978 from Patent EP1572962. JD373644 - Sequence 354668 from Patent EP1572962. JD134585 - Sequence 115609 from Patent EP1572962. JD097354 - Sequence 78378 from Patent EP1572962. JD363771 - Sequence 344795 from Patent EP1572962. JD353908 - Sequence 334932 from Patent EP1572962. JD089012 - Sequence 70036 from Patent EP1572962. JD534219 - Sequence 515243 from Patent EP1572962. JD097131 - Sequence 78155 from Patent EP1572962. JD050674 - Sequence 31698 from Patent EP1572962. JD050676 - Sequence 31700 from Patent EP1572962. JD451928 - Sequence 432952 from Patent EP1572962. JD083427 - Sequence 64451 from Patent EP1572962. JD466403 - Sequence 447427 from Patent EP1572962. JD471333 - Sequence 452357 from Patent EP1572962. JD179028 - Sequence 160052 from Patent EP1572962. JD524413 - Sequence 505437 from Patent EP1572962. JD482950 - Sequence 463974 from Patent EP1572962. JD382582 - Sequence 363606 from Patent EP1572962. JD203429 - Sequence 184453 from Patent EP1572962. JD096898 - Sequence 77922 from Patent EP1572962. JD357737 - Sequence 338761 from Patent EP1572962. JD092755 - Sequence 73779 from Patent EP1572962. JD189974 - Sequence 170998 from Patent EP1572962. JD460278 - Sequence 441302 from Patent EP1572962. JD199941 - Sequence 180965 from Patent EP1572962. JD111899 - Sequence 92923 from Patent EP1572962. JD539944 - Sequence 520968 from Patent EP1572962. JD045515 - Sequence 26539 from Patent EP1572962. JD512955 - Sequence 493979 from Patent EP1572962. JD432221 - Sequence 413245 from Patent EP1572962. JD042005 - Sequence 23029 from Patent EP1572962. JD462098 - Sequence 443122 from Patent EP1572962. JD068351 - Sequence 49375 from Patent EP1572962. JD360940 - Sequence 341964 from Patent EP1572962. JD227245 - Sequence 208269 from Patent EP1572962.

Other Names for This Gene


	Alternate Gene Symbols: CSR, ENST00000301904.1, ENST00000301904.2, ENST00000301904.3, NM_016240, Q6AZY7, Q9UM15, Q9UM16, SCAR3_HUMAN, uc317mxk.1, uc317mxk.2 UCSC ID: ENST00000301904.4_4 RefSeq Accession: NM_016240.3 Protein: Q6AZY7 (aka SCAR3_HUMAN)

Gene Model Information


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Methods, Credits, and Use Restrictions


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