ID:SARNP_HUMAN DESCRIPTION: RecName: Full=SAP domain-containing ribonucleoprotein; AltName: Full=Cytokine-induced protein of 29 kDa; AltName: Full=Nuclear protein Hcc-1; AltName: Full=Proliferation-associated cytokine-inducible protein CIP29; FUNCTION: Binds both single-stranded and double-stranded DNA with higher affinity for the single-stranded form. Specifically binds to scaffold/matrix attachment region DNA. Also binds single- stranded RNA. Enhances RNA unwinding activity of DDX39A. May participate in important transcriptional or translational control of cell growth, metabolism and carcinogenesis. SUBUNIT: Interacts with DDX39A. Interacts with FUS. SUBCELLULAR LOCATION: Nucleus. TISSUE SPECIFICITY: Low expression in spleen, liver, pancreas, testis, thymus, heart, and kidney. Increased levels are seen in hepatocellular carcinoma and pancreatic adenocarcinoma. INDUCTION: By EPO/erythropoietin. SIMILARITY: Contains 1 SAP domain. SEQUENCE CAUTION: Sequence=AAF28994.1; Type=Frameshift; Positions=134, 149; WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/CIP29ID42967ch12q13.html";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P82979
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
AK290508 - Homo sapiens cDNA FLJ76495 complete cds, highly similar to Homo sapiens cytokine induced protein 29 kDa (CIP29), mRNA. BC093051 - Homo sapiens cytokine induced protein 29 kDa, mRNA (cDNA clone MGC:111129 IMAGE:30382893), complete cds. KJ894983 - Synthetic construct Homo sapiens clone ccsbBroadEn_04377 SARNP gene, encodes complete protein. KJ903416 - Synthetic construct Homo sapiens clone ccsbBroadEn_12810 SARNP gene, encodes complete protein. AF161434 - Homo sapiens HSPC316 mRNA, partial cds. BC007099 - Homo sapiens cytokine induced protein 29 kDa, mRNA (cDNA clone MGC:14726 IMAGE:4273903), complete cds. BC016941 - Homo sapiens DnaJ (Hsp40) homolog, subfamily C, member 14, mRNA (cDNA clone IMAGE:3448446). AF486281 - Homo sapiens proliferation associated cytokine-inducible protein CIP29 mRNA, complete cds. EU446946 - Synthetic construct Homo sapiens clone IMAGE:100070161; IMAGE:100012155; FLH257548.01L cytokine induced protein 29 kDa (CIP29) gene, encodes complete protein. AB463939 - Synthetic construct DNA, clone: pF1KB7567, Homo sapiens HCC1 gene for Nuclear protein Hcc-1, without stop codon, in Flexi system. JD021027 - Sequence 2051 from Patent EP1572962. AK222719 - Homo sapiens mRNA, cytokine induced protein 29 kDa variant, clone: COL06757.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein P82979 (Reactome details) participates in the following event(s):
R-HSA-8849157 TREX complex binds spliced, capped mRNA:CBC:EJC cotranscriptionally R-HSA-75096 Docking of the TAP:EJC Complex with the NPC R-HSA-72185 mRNA polyadenylation R-HSA-72180 Cleavage of mRNA at the 3'-end R-HSA-159101 NXF1:NXT1 (TAP:p15) binds capped mRNA:CBC:EJC:TREX (minus DDX39B) R-HSA-72187 mRNA 3'-end processing R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA R-HSA-72202 Transport of Mature Transcript to Cytoplasm R-HSA-109688 Cleavage of Growing Transcript in the Termination Region R-HSA-8953854 Metabolism of RNA R-HSA-73856 RNA Polymerase II Transcription Termination R-HSA-73857 RNA Polymerase II Transcription R-HSA-74160 Gene expression (Transcription)
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
