ID:MTG8_HUMAN DESCRIPTION: RecName: Full=Protein CBFA2T1; AltName: Full=Cyclin-D-related protein; AltName: Full=Eight twenty one protein; AltName: Full=Protein ETO; AltName: Full=Protein MTG8; AltName: Full=Zinc finger MYND domain-containing protein 2; FUNCTION: Transcription regulator that excerts its function by binding to histone deacetylases and transcription factors. Can repress transactivation mediated by TCF12. SUBUNIT: Homotetramer. Heterotetramer with CBFA2T2 and CBFA2T3. Interacts with TCF12, SIN3A, HDAC1, HDAC2, HDAC3, NCOR1 and NCOR2. Interacts with ATN1 (via its N-terminus); the interaction enhances the transcriptional repression. INTERACTION: Self; NbExp=2; IntAct=EBI-743342, EBI-743342; SUBCELLULAR LOCATION: Nucleus. Note=Colocalizes with ATN1 in discrete nuclear dots. TISSUE SPECIFICITY: Most abundantly expressed in brain. Lower levels in lung, heart, testis and ovary. DOMAIN: The TAFH domain mediates interaction with transcription regulators. DISEASE: Note=A chromosomal aberration involving RUNX1T1 is a cause of acute myeloid leukemia (AML-M2). Translocation t(8;21)(q22;q22) with RUNX1/AML1. DISEASE: Defects in RUNX1T1 may be a cause of colorectal cancer (CRC) [MIM:114500]. SIMILARITY: Belongs to the CBFA2T family. SIMILARITY: Contains 1 MYND-type zinc finger. SIMILARITY: Contains 1 TAFH (NHR1) domain. SEQUENCE CAUTION: Sequence=AAH05850.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAA03247.1; Type=Erroneous initiation; Note=Translation N-terminally extended; WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/ETO.html";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q06455
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0003677 DNA binding GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0003714 transcription corepressor activity GO:0005515 protein binding GO:0046872 metal ion binding
Biological Process: GO:0006091 generation of precursor metabolites and energy GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0045599 negative regulation of fat cell differentiation GO:0045892 negative regulation of transcription, DNA-templated
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
