Human Gene RSU1 (ENST00000345264.10_7) from GENCODE V47lift37

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Description: Ras suppressor protein 1, transcript variant 1 (from RefSeq NM_012425.4)
Gencode Transcript: ENST00000345264.10_7
Gencode Gene: ENSG00000148484.18_10
Transcript (Including UTRs)
Position: hg19 chr10:16,632,610-16,859,423 Size: 226,814 Total Exon Count: 9 Strand: -
Coding Region
Position: hg19 chr10:16,635,393-16,859,080 Size: 223,688 Coding Exon Count: 8

Page Index	Sequence and Links	UniProtKB Comments	Primers	CTD	Gene Alleles
RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species	GO Annotations
mRNA Descriptions	Pathways	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr10:16,632,610-16,859,423)			mRNA (may differ from genome)		Protein (277 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	MGI	OMIM	PubMed	Reactome	UniProtKB
Wikipedia	BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: RSU1_HUMAN DESCRIPTION: RecName: Full=Ras suppressor protein 1; Short=RSP-1; Short=Rsu-1; FUNCTION: Potentially plays a role in the Ras signal transduction pathway. Capable of suppressing v-Ras transformation in vitro. SIMILARITY: Contains 7 LRR (leucine-rich) repeats.

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D004958 Estradiol C025643 vinclozolin C111118 2',3,3',4',5-pentachloro-4-hydroxybiphenyl C029497 2,3-bis(3'-hydroxybenzyl)butyrolactone C009505 4,4'-diaminodiphenylmethane D016604 Aflatoxin B1 D001564 Benzo(a)pyrene D002945 Cisplatin D003375 Coumestrol D016572 Cyclosporine more ... click here to view the complete list

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 47.59 RPKM in Artery - Tibial Total median expression: 806.59 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-36.50	113	-0.323	Picture	PostScript	Text
3' UTR	-704.00	2783	-0.253	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR001611 - Leu-rich_rpt
IPR025875 - Leu-rich_rpt_2_copies
IPR003591 - Leu-rich_rpt_typical-subtyp

Pfam Domains:
PF12799 - Leucine Rich repeats (2 copies)
PF13855 - Leucine rich repeat

SCOP Domains:
52047 - RNI-like
52058 - L domain-like
52075 - Outer arm dynein light chain 1

ModBase Predicted Comparative 3D Structure on Q15404


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details	Gene Details		Gene Details
Gene Sorter	Gene Sorter		Gene Sorter
	RGD	Ensembl

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0005515 protein binding Biological Process: GO:0007165 signal transduction GO:0010811 positive regulation of cell-substrate adhesion GO:0043547 positive regulation of GTPase activity GO:0010810 regulation of cell-substrate adhesion Cellular Component: GO:0005829 cytosol GO:0005925 focal adhesion GO:0070062 extracellular exosome

Descriptions from all associated GenBank mRNAs


	BX647733 - Homo sapiens mRNA; cDNA DKFZp686J03262 (from clone DKFZp686J03262). L12535 - Human RSU-1/RSP-1 mRNA, complete cds. BC005993 - Homo sapiens Ras suppressor protein 1, mRNA (cDNA clone MGC:14796 IMAGE:4050837), complete cds. BC107898 - Homo sapiens Ras suppressor protein 1, mRNA (cDNA clone IMAGE:30320269), partial cds. BC015644 - Homo sapiens Ras suppressor protein 1, mRNA (cDNA clone MGC:23361 IMAGE:4647836), complete cds. BC008691 - Homo sapiens Ras suppressor protein 1, mRNA (cDNA clone MGC:8886 IMAGE:3872071), complete cds. AK292911 - Homo sapiens cDNA FLJ77304 complete cds, highly similar to Homo sapiens Ras suppressor protein 1 (RSU1), transcript variant 2, mRNA. CR536521 - Homo sapiens full open reading frame cDNA clone RZPDo834D1120D for gene RSU1, Ras suppressor protein 1; complete cds, incl. stopcodon. AK312520 - Homo sapiens cDNA, FLJ92885, Homo sapiens Ras suppressor protein 1 (RSU1), mRNA. CU679047 - Synthetic construct Homo sapiens gateway clone IMAGE:100016954 5' read RSU1 mRNA. KJ892075 - Synthetic construct Homo sapiens clone ccsbBroadEn_01469 RSU1 gene, encodes complete protein. CR541840 - Homo sapiens full open reading frame cDNA clone RZPDo834B1032D for gene RSU1, Ras suppressor protein 1; complete cds, without stopcodon. AB590762 - Synthetic construct DNA, clone: pFN21AE1771, Homo sapiens RSU1 gene for Ras suppressor protein 1, without stop codon, in Flexi system. BC016337 - Homo sapiens Ras suppressor protein 1, mRNA (cDNA clone IMAGE:4102897), with apparent retained intron. AK055596 - Homo sapiens cDNA FLJ31034 fis, clone HSYRA1000178. BC065296 - Homo sapiens cDNA clone IMAGE:6139254, partial cds. JD509748 - Sequence 490772 from Patent EP1572962. JD517665 - Sequence 498689 from Patent EP1572962. JD091286 - Sequence 72310 from Patent EP1572962. JD183278 - Sequence 164302 from Patent EP1572962. JD333525 - Sequence 314549 from Patent EP1572962. JD176321 - Sequence 157345 from Patent EP1572962. JD055179 - Sequence 36203 from Patent EP1572962. JD306307 - Sequence 287331 from Patent EP1572962. JD074703 - Sequence 55727 from Patent EP1572962. JD178983 - Sequence 160007 from Patent EP1572962. JD169646 - Sequence 150670 from Patent EP1572962. JD529391 - Sequence 510415 from Patent EP1572962. JD091698 - Sequence 72722 from Patent EP1572962. JD421515 - Sequence 402539 from Patent EP1572962. JD294140 - Sequence 275164 from Patent EP1572962. JD514948 - Sequence 495972 from Patent EP1572962. JD423519 - Sequence 404543 from Patent EP1572962. JD046021 - Sequence 27045 from Patent EP1572962. JD362357 - Sequence 343381 from Patent EP1572962. JD498111 - Sequence 479135 from Patent EP1572962. JD343988 - Sequence 325012 from Patent EP1572962. JD249897 - Sequence 230921 from Patent EP1572962. JD148333 - Sequence 129357 from Patent EP1572962. JD463845 - Sequence 444869 from Patent EP1572962. JD478596 - Sequence 459620 from Patent EP1572962. JD543284 - Sequence 524308 from Patent EP1572962. JD249896 - Sequence 230920 from Patent EP1572962. JD501099 - Sequence 482123 from Patent EP1572962. JD492795 - Sequence 473819 from Patent EP1572962. JD328092 - Sequence 309116 from Patent EP1572962. JD102360 - Sequence 83384 from Patent EP1572962. JD302452 - Sequence 283476 from Patent EP1572962. JD504649 - Sequence 485673 from Patent EP1572962. JD556649 - Sequence 537673 from Patent EP1572962. JD048262 - Sequence 29286 from Patent EP1572962. JD049190 - Sequence 30214 from Patent EP1572962. JD303262 - Sequence 284286 from Patent EP1572962. JD385669 - Sequence 366693 from Patent EP1572962. JD551758 - Sequence 532782 from Patent EP1572962. JD325668 - Sequence 306692 from Patent EP1572962. JD317084 - Sequence 298108 from Patent EP1572962. JD275096 - Sequence 256120 from Patent EP1572962. JD391015 - Sequence 372039 from Patent EP1572962. AK225681 - Homo sapiens mRNA for ras suppressor protein 1 isoform 1 variant, clone: SYN02524. AK023951 - Homo sapiens cDNA FLJ13889 fis, clone THYRO1001595. JD396720 - Sequence 377744 from Patent EP1572962.

Biochemical and Signaling Pathways


	Reactome (by CSHL, EBI, and GO) Protein Q15404 (Reactome details) participates in the following event(s): R-HSA-430311 Rsu-1 interacts with Pinch1 R-HSA-446388 Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446353 Cell-extracellular matrix interactions R-HSA-446728 Cell junction organization R-HSA-1500931 Cell-Cell communication

Other Names for This Gene


	Alternate Gene Symbols: A8KA46, D3DRU3, ENST00000345264.1, ENST00000345264.2, ENST00000345264.3, ENST00000345264.4, ENST00000345264.5, ENST00000345264.6, ENST00000345264.7, ENST00000345264.8, ENST00000345264.9, NM_012425, Q15404, Q6FI17, RSP1, RSU1_HUMAN, uc317xey.1, uc317xey.2 UCSC ID: ENST00000345264.10_7 RefSeq Accession: NM_012425.4 Protein: Q15404 (aka RSU1_HUMAN)

Gene Model Information


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Methods, Credits, and Use Restrictions


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