ID:RRN3_HUMAN DESCRIPTION: RecName: Full=RNA polymerase I-specific transcription initiation factor RRN3; AltName: Full=Transcription initiation factor IA; Short=TIF-IA; FUNCTION: Required for efficient transcription initiation by RNA polymerase I. Required for the formation of the competent preinitiation complex (PIC). Dissociates from pol I as a consequence of transcription. In vitro, cannot activate transcription in a subsequent transcription reaction (By similarity). SUBUNIT: Interacts with TWISTNB, EIF3L, TAF1B and TAF1C. SUBCELLULAR LOCATION: Nucleus, nucleolus. PTM: Phosphorylation is required for participation in rDNA transcription (By similarity). Phosphorylated at Thr-200 by MAPK9/JNK2, which abrogates initiation complex formation. SIMILARITY: Belongs to the RRN3 family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9NYV6
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0001042 RNA polymerase I core binding GO:0001164 RNA polymerase I CORE element sequence-specific DNA binding GO:0001181 transcription factor activity, core RNA polymerase I binding GO:0070063 RNA polymerase binding
Biological Process: GO:0001188 RNA polymerase I transcriptional preinitiation complex assembly GO:0001701 in utero embryonic development GO:0006351 transcription, DNA-templated GO:0006352 DNA-templated transcription, initiation GO:0006355 regulation of transcription, DNA-templated GO:0006356 regulation of transcription from RNA polymerase I promoter GO:0006361 transcription initiation from RNA polymerase I promoter GO:0007000 nucleolus organization GO:0007028 cytoplasm organization GO:0008283 cell proliferation GO:0010976 positive regulation of neuron projection development GO:0042254 ribosome biogenesis GO:0045893 positive regulation of transcription, DNA-templated GO:0048872 homeostasis of number of cells GO:1902254 negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator GO:2000142 regulation of DNA-templated transcription, initiation
BC036182 - Homo sapiens RRN3 RNA polymerase I transcription factor homolog (S. cerevisiae), mRNA (cDNA clone IMAGE:5298581). AJ272050 - Homo sapiens mRNA for transcription initiation factor IA protein (TIF-IA gene). LP896031 - Sequence 895 from Patent EP3253886. AK225662 - Homo sapiens mRNA for RRN3 RNA polymerase I transcription factor homolog, clone: STM04189. AL110238 - Homo sapiens mRNA; cDNA DKFZp566E104 (from clone DKFZp566E104). JD469281 - Sequence 450305 from Patent EP1572962. JD314711 - Sequence 295735 from Patent EP1572962. JD202996 - Sequence 184020 from Patent EP1572962. BC071868 - Homo sapiens RRN3 RNA polymerase I transcription factor homolog (S. cerevisiae), mRNA (cDNA clone IMAGE:6278263), partial cds. JD074404 - Sequence 55428 from Patent EP1572962. JD197650 - Sequence 178674 from Patent EP1572962. JD358197 - Sequence 339221 from Patent EP1572962. JD053188 - Sequence 34212 from Patent EP1572962. JD512365 - Sequence 493389 from Patent EP1572962. BC132688 - Homo sapiens RRN3 RNA polymerase I transcription factor homolog (S. cerevisiae), mRNA (cDNA clone MGC:164319 IMAGE:40146710), complete cds. BC132690 - Homo sapiens RRN3 RNA polymerase I transcription factor homolog (S. cerevisiae), mRNA (cDNA clone MGC:164321 IMAGE:40146712), complete cds. JD560373 - Sequence 541397 from Patent EP1572962. JD357508 - Sequence 338532 from Patent EP1572962. JD310163 - Sequence 291187 from Patent EP1572962. JD302218 - Sequence 283242 from Patent EP1572962. JD210555 - Sequence 191579 from Patent EP1572962. JD482014 - Sequence 463038 from Patent EP1572962. JD331425 - Sequence 312449 from Patent EP1572962. AK295486 - Homo sapiens cDNA FLJ56083 complete cds, highly similar to RNA polymerase I-specific transcriptioninitiation factor RRN3. AK316520 - Homo sapiens cDNA, FLJ79419 complete cds, highly similar to RNA polymerase I-specific transcription initiation factor RRN3. JD433003 - Sequence 414027 from Patent EP1572962. AK302994 - Homo sapiens cDNA FLJ55505 complete cds, highly similar to RNA polymerase I-specific transcription initiation factor RRN3. AK304856 - Homo sapiens cDNA FLJ53965 complete cds, highly similar to RNA polymerase I-specific transcription initiation factor RRN3. AK300253 - Homo sapiens cDNA FLJ50670 complete cds, highly similar to RNA polymerase I-specific transcription initiation factor RRN3. AF227156 - Homo sapiens RRN3 mRNA, complete cds. AK303405 - Homo sapiens cDNA FLJ52380 complete cds, highly similar to RNA polymerase I-specific transcriptioninitiation factor RRN3. AK314769 - Homo sapiens cDNA, FLJ95638, Homo sapiens RNA polymerase I transcription factor RRN3 (RRN3),mRNA. HQ258337 - Synthetic construct Homo sapiens clone IMAGE:100072646 RRN3 RNA polymerase I transcription factor homolog (S. cerevisiae) (RRN3) gene, encodes complete protein. KJ894052 - Synthetic construct Homo sapiens clone ccsbBroadEn_03446 RRN3 gene, encodes complete protein. AB527833 - Synthetic construct DNA, clone: pF1KB7886, Homo sapiens RRN3 gene for RRN3 RNA polymerase I transcription factor homolog, without stop codon, in Flexi system. JD065213 - Sequence 46237 from Patent EP1572962. JD405335 - Sequence 386359 from Patent EP1572962. BC104660 - Homo sapiens RRN3 RNA polymerase I transcription factor homolog (S. cerevisiae), mRNA (cDNA clone IMAGE:4612605), complete cds. AK092795 - Homo sapiens cDNA FLJ35476 fis, clone SMINT2007579. JD550888 - Sequence 531912 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q9NYV6 (Reactome details) participates in the following event(s):
R-HSA-73757 Binding of RRN3 to RNA Polymerase I R-HSA-73769 Loss of Rrn3 from RNA Polymerase I promoter escape complex R-HSA-73758 Recruitment of Active RNA Polymerase I to SL1:phos.UBF-1:rDNA Promoter R-HSA-73762 RNA Polymerase I Transcription Initiation R-HSA-73772 RNA Polymerase I Promoter Escape R-HSA-73854 RNA Polymerase I Promoter Clearance R-HSA-73864 RNA Polymerase I Transcription R-HSA-74160 Gene expression (Transcription)
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
