Human Gene RRBP1 (ENST00000377813.6_16) from GENCODE V47lift37

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Description: ribosome binding protein 1, transcript variant 3 (from RefSeq NM_001365613.2)
Gencode Transcript: ENST00000377813.6_16
Gencode Gene: ENSG00000125844.17_22
Transcript (Including UTRs)
Position: hg19 chr20:17,594,324-17,662,887 Size: 68,564 Total Exon Count: 25 Strand: -
Coding Region
Position: hg19 chr20:17,594,827-17,641,152 Size: 46,326 Coding Exon Count: 23

Page Index	Sequence and Links	UniProtKB Comments	Primers	CTD	Gene Alleles
RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species	GO Annotations
mRNA Descriptions	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr20:17,594,324-17,662,887)			mRNA (may differ from genome)		Protein (1410 aa)
Gene Sorter	Genome Browser	Other Species FASTA	Gene interactions	Table Schema	AlphaFold
BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards	HGNC
MGI	OMIM	PubMed	UniProtKB	Wikipedia	BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: RRBP1_HUMAN DESCRIPTION: RecName: Full=Ribosome-binding protein 1; AltName: Full=180 kDa ribosome receptor homolog; Short=RRp; AltName: Full=ES/130-related protein; AltName: Full=Ribosome receptor protein; FUNCTION: Acts as a ribosome receptor and mediates interaction between the ribosome and the endoplasmic reticulum membrane (By similarity). SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Single-pass type III membrane protein (By similarity). SEQUENCE CAUTION: Sequence=BAA92636.2; Type=Erroneous initiation;

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D013749 Tetrachlorodibenzodioxin C547126 AZM551248 D000082 Acetaminophen D001564 Benzo(a)pyrene D002794 Choline D002922 Ciguatoxins D019327 Copper Sulfate D016572 Cyclosporine D004041 Dietary Fats D004997 Ethinyl Estradiol more ... click here to view the complete list

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 137.56 RPKM in Pancreas Total median expression: 1657.54 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-132.60	313	-0.424	Picture	PostScript	Text
3' UTR	-164.00	503	-0.326	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR007794 - Rib_rcpt_KP

Pfam Domains:
PF05104 - Ribosome receptor lysine/proline rich region

ModBase Predicted Comparative 3D Structure on Q9P2E9


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details	Gene Details
Gene Sorter	Gene Sorter
	RGD	Ensembl

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0003723 RNA binding GO:0038023 signaling receptor activity Biological Process: GO:0001649 osteoblast differentiation GO:0006412 translation GO:0007165 signal transduction GO:0015031 protein transport Cellular Component: GO:0005783 endoplasmic reticulum GO:0005789 endoplasmic reticulum membrane GO:0005840 ribosome GO:0016020 membrane GO:0016021 integral component of membrane GO:0030176 integral component of endoplasmic reticulum membrane

Descriptions from all associated GenBank mRNAs


	AK098319 - Homo sapiens cDNA FLJ41000 fis, clone UTERU2016761, highly similar to Homo sapiens ES/130 mRNA. AB037819 - Homo sapiens mRNA for KIAA1398 protein, partial cds. BC000099 - Homo sapiens ribosome binding protein 1 homolog 180kDa (dog), mRNA (cDNA clone IMAGE:3509994), partial cds. AF006751 - Homo sapiens ES/130 mRNA, complete cds. AK093465 - Homo sapiens cDNA FLJ36146 fis, clone TESTI2025117, highly similar to Ribosome-binding protein 1. BC128578 - Homo sapiens ribosome binding protein 1 homolog 180kDa (dog), mRNA (cDNA clone MGC:157721 IMAGE:40128742), complete cds. BC128577 - Homo sapiens ribosome binding protein 1 homolog 180kDa (dog), mRNA (cDNA clone MGC:157720 IMAGE:40128738), complete cds. JD482978 - Sequence 464002 from Patent EP1572962. JD361010 - Sequence 342034 from Patent EP1572962. JD197603 - Sequence 178627 from Patent EP1572962. AB287347 - Homo sapiens RRBP1 mRNA for p180/ribosome receptor, complete cds. AB384598 - Synthetic construct DNA, clone: pF1KA1398, Homo sapiens RRBP1 gene for ribosome-binding protein 1, complete cds, without stop codon, in Flexi system. BC080526 - Homo sapiens ribosome binding protein 1 homolog 180kDa (dog), mRNA (cDNA clone IMAGE:4561660). BC020482 - Homo sapiens ribosome binding protein 1 homolog 180kDa (dog), mRNA (cDNA clone IMAGE:3919185). AL833822 - Homo sapiens mRNA; cDNA DKFZp586A1420 (from clone DKFZp586A1420). AK309197 - Homo sapiens cDNA, FLJ99238. DQ580579 - Homo sapiens piRNA piR-48691, complete sequence. DQ571749 - Homo sapiens piRNA piR-31861, complete sequence. DQ577484 - Homo sapiens piRNA piR-45596, complete sequence. AF007575 - Homo sapiens ES/130-related protein mRNA, partial cds. BC108741 - Homo sapiens ribosome binding protein 1 homolog 180kDa (dog), mRNA (cDNA clone IMAGE:6156239), partial cds. DQ591440 - Homo sapiens piRNA piR-58552, complete sequence. JD202083 - Sequence 183107 from Patent EP1572962.

Other Names for This Gene


	Alternate Gene Symbols: A0A0A0MRV0, A2A2S6, A6NCN6, ENST00000377813.1, ENST00000377813.2, ENST00000377813.3, ENST00000377813.4, ENST00000377813.5, KIAA1398, NM_001365613, O75300, O75301, Q5W165, Q96SB2, Q9BWP1, Q9H476, Q9P2E9, RRBP1_HUMAN, uc318nwf.1, uc318nwf.2 UCSC ID: ENST00000377813.6_16 RefSeq Accession: NM_001365613.2 Protein: Q9P2E9 (aka RRBP1_HUMAN or RRB1_HUMAN)

Gene Model Information


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Methods, Credits, and Use Restrictions


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