ID:KS6A2_HUMAN DESCRIPTION: RecName: Full=Ribosomal protein S6 kinase alpha-2; Short=S6K-alpha-2; EC=2.7.11.1; AltName: Full=90 kDa ribosomal protein S6 kinase 2; Short=p90-RSK 2; Short=p90RSK2; AltName: Full=MAP kinase-activated protein kinase 1c; Short=MAPK-activated protein kinase 1c; Short=MAPKAP kinase 1c; Short=MAPKAPK-1c; AltName: Full=Ribosomal S6 kinase 3; Short=RSK-3; AltName: Full=pp90RSK3; FUNCTION: Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of transcription factors, regulates translation, and mediates cellular proliferation, survival, and differentiation. May function as tumor suppressor in epithelial ovarian cancer cells. CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein. COFACTOR: Magnesium. ENZYME REGULATION: Upon extracellular signal or mitogen stimulation, phosphorylated at Thr-570 in the C-terminal kinase domain (CTKD) by MAPK1/ERK2 and MAPK3/ERK1. The activated CTKD then autophosphorylates Ser-377, allowing binding of PDPK1, which in turn phosphorylates Ser-218 in the N-terminal kinase domain (NTDK) leading to the full activation of the protein and subsequent phosphorylation of the substrates by the NTKD. SUBUNIT: Forms a complex with either MAPK1/ERK2 or MAPK3/ERK1 in quiescent cells. Transiently dissociates following mitogenic stimulation (By similarity). SUBCELLULAR LOCATION: Nucleus. Cytoplasm. TISSUE SPECIFICITY: Widely expressed with higher expression in lung, skeletal muscle, brain, uterus, ovary, thyroid and prostate. PTM: Activated by phosphorylation at Ser-218 by PDPK1. Autophosphorylated on Ser-377, as part of the activation process. May be phosphorylated at Thr-356 and Ser-360 by MAPK1/ERK2 and MAPK3/ERK1 (By similarity). PTM: N-terminal myristoylation results in an activated kinase in the absence of added growth factors (By similarity). SIMILARITY: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. SIMILARITY: Contains 1 AGC-kinase C-terminal domain. SIMILARITY: Contains 2 protein kinase domains. SEQUENCE CAUTION: Sequence=AAC82496.1; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=BAD92353.1; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=BAG53121.1; Type=Frameshift; Positions=527;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q15349
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006468 protein phosphorylation GO:0007165 signal transduction GO:0008285 negative regulation of cell proliferation GO:0016310 phosphorylation GO:0035556 intracellular signal transduction GO:0043065 positive regulation of apoptotic process GO:0045786 negative regulation of cell cycle
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
