ID:RS3A_HUMAN DESCRIPTION: RecName: Full=40S ribosomal protein S3a; AltName: Full=v-fos transformation effector protein; Short=Fte-1; FUNCTION: May play a role during erythropoiesis through regulation of transcription factor DDIT3 (By similarity). SUBUNIT: Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S). Identified in a mRNP granule complex, at least composed of ACTB, ACTN4, DHX9, ERG, HNRNPA1, HNRNPA2B1, HNRNPAB, HNRNPD, HNRNPL, HNRNPR, HNRNPU, HSPA1, HSPA8, IGF2BP1, ILF2, ILF3, NCBP1, NCL, PABPC1, PABPC4, PABPN1, RPLP0, RPS3, RPS3A, RPS4X, RPS8, RPS9, SYNCRIP, TROVE2, YBX1 and untranslated mRNAs. Binds with high affinity to IPO4. Interacts with DDIT3 (By similarity). INTERACTION: P07900:HSP90AA1; NbExp=2; IntAct=EBI-352378, EBI-296047; SUBCELLULAR LOCATION: Cytoplasm. Nucleus (By similarity). Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. SIMILARITY: Belongs to the ribosomal protein S3Ae family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P61247
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
KJ892052 - Synthetic construct Homo sapiens clone ccsbBroadEn_01446 RPS3A gene, encodes complete protein. BC001708 - Homo sapiens ribosomal protein S3A, mRNA (cDNA clone MGC:1626 IMAGE:3544072), complete cds. M84711 - Human v-fos transformation effector protein (Fte-1), mRNA complete cds. AK308947 - Homo sapiens cDNA, FLJ98988. BC070211 - Homo sapiens ribosomal protein S3A, mRNA (cDNA clone MGC:88192 IMAGE:5809691), complete cds. D28374 - Homo sapiens mRNA for ribosomal protein S3a, 5'UTR region. AK296121 - Homo sapiens cDNA FLJ51870 complete cds, highly similar to 40S ribosomal protein S3a. AK291075 - Homo sapiens cDNA FLJ78591 complete cds, highly similar to Homo sapiens ribosomal protein S3A (RPS3A), mRNA. BC066926 - Homo sapiens ribosomal protein S3A, mRNA (cDNA clone MGC:87201 IMAGE:4826149), complete cds. AK311788 - Homo sapiens cDNA, FLJ92049, Homo sapiens ribosomal protein S3A (RPS3A), mRNA. AK129825 - Homo sapiens cDNA FLJ26315 fis, clone DMC09112, highly similar to 40S ribosomal protein S3A. JD022483 - Sequence 3507 from Patent EP1572962. DL491014 - Novel nucleic acids. M77234 - Human ribosomal protein S3a mRNA, complete cds. BC009404 - Homo sapiens ribosomal protein S3A, mRNA (cDNA clone MGC:15425 IMAGE:4308955), complete cds. BC018954 - Homo sapiens ribosomal protein S3A, mRNA (cDNA clone IMAGE:4136755). BC000204 - Homo sapiens ribosomal protein S3A, mRNA (cDNA clone MGC:3109 IMAGE:3350750), complete cds. BC009219 - Homo sapiens ribosomal protein S3A, mRNA (cDNA clone MGC:16359 IMAGE:3927639), complete cds. BC017123 - Homo sapiens ribosomal protein S3A, mRNA (cDNA clone MGC:18002 IMAGE:3922810), complete cds. BC071916 - Homo sapiens ribosomal protein S3A, mRNA (cDNA clone MGC:88598 IMAGE:6285242), complete cds. BC094829 - Homo sapiens cDNA clone IMAGE:4647813, **** WARNING: chimeric clone ****. BC004981 - Homo sapiens ribosomal protein S3A, mRNA (cDNA clone MGC:3883 IMAGE:2906117), complete cds. JD031337 - Sequence 12361 from Patent EP1572962. L13802 - Homo sapiens (clone 03) liver expessed ribosomal protein S3 homologue mRNA, complete cds. BC006298 - Homo sapiens ribosomal protein S3A, mRNA (cDNA clone MGC:13266 IMAGE:4079651), complete cds. DQ894322 - Synthetic construct Homo sapiens clone IMAGE:100008782; FLH169692.01L; RZPDo839F0295D ribosomal protein S3A (RPS3A) gene, encodes complete protein. DQ891143 - Synthetic construct clone IMAGE:100003773; FLH169696.01X; RZPDo839F0296D ribosomal protein S3A (RPS3A) gene, encodes complete protein. AB464167 - Synthetic construct DNA, clone: pF1KB3451, Homo sapiens RPS3A gene for ribosomal protein S3A, without stop codon, in Flexi system. CU688198 - Synthetic construct Homo sapiens gateway clone IMAGE:100021072 5' read RPS3A mRNA. LF323768 - JP 2014500723-A/131271: Polycomb-Associated Non-Coding RNAs. LF323767 - JP 2014500723-A/131270: Polycomb-Associated Non-Coding RNAs. LF323766 - JP 2014500723-A/131269: Polycomb-Associated Non-Coding RNAs. JD025523 - Sequence 6547 from Patent EP1572962. LF323765 - JP 2014500723-A/131268: Polycomb-Associated Non-Coding RNAs. JD035553 - Sequence 16577 from Patent EP1572962. DQ581894 - Homo sapiens piRNA piR-50006, complete sequence. LF323764 - JP 2014500723-A/131267: Polycomb-Associated Non-Coding RNAs. JD147346 - Sequence 128370 from Patent EP1572962. LF323763 - JP 2014500723-A/131266: Polycomb-Associated Non-Coding RNAs. LF323762 - JP 2014500723-A/131265: Polycomb-Associated Non-Coding RNAs. JD040787 - Sequence 21811 from Patent EP1572962. MA559345 - JP 2018138019-A/131271: Polycomb-Associated Non-Coding RNAs. MA559344 - JP 2018138019-A/131270: Polycomb-Associated Non-Coding RNAs. MA559343 - JP 2018138019-A/131269: Polycomb-Associated Non-Coding RNAs. MA559342 - JP 2018138019-A/131268: Polycomb-Associated Non-Coding RNAs. MA559341 - JP 2018138019-A/131267: Polycomb-Associated Non-Coding RNAs. MA559340 - JP 2018138019-A/131266: Polycomb-Associated Non-Coding RNAs. MA559339 - JP 2018138019-A/131265: Polycomb-Associated Non-Coding RNAs.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein P61247 (Reactome details) participates in the following event(s):
R-HSA-72676 eIF3 and eIF1A bind to the 40S subunit R-HSA-72673 Release of 40S and 60S subunits from the 80S ribosome R-HSA-72672 The 60S subunit joins the translation initiation complex R-HSA-72619 eIF2:GTP is hydrolyzed, eIFs are released R-HSA-72691 Formation of the 43S pre-initiation complex R-HSA-156808 Formation of translation initiation complexes yielding circularized Ceruloplasmin mRNA in a 'closed-loop' conformation R-HSA-157849 Formation of translation initiation complexes containing mRNA that does not circularize R-HSA-72671 eIF5B:GTP is hydrolyzed and released R-HSA-156907 Aminoacyl-tRNA binds to the ribosome at the A-site R-HSA-2408529 Sec-tRNA(Sec):EEFSEC:GTP binds to 80S Ribosome R-HSA-141691 GTP bound eRF3:eRF1 complex binds the peptidyl tRNA:mRNA:80S Ribosome complex R-HSA-156915 Translocation of ribosome by 3 bases in the 3' direction R-HSA-141671 Polypeptide release from the eRF3-GDP:eRF1:mRNA:80S Ribosome complex R-HSA-156912 Peptide transfer from P-site tRNA to the A-site tRNA R-HSA-927832 UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex R-HSA-927789 Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex R-HSA-1799332 Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP) R-HSA-156923 Hydrolysis of eEF1A:GTP R-HSA-72621 Ribosomal scanning R-HSA-72697 Start codon recognition R-HSA-156823 Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA R-HSA-5333615 80S:Met-tRNAi:mRNA:SECISBP2:Sec-tRNA(Sec):EEFSEC:GTP is hydrolysed to 80S:Met-tRNAi:mRNA:SECISBP2:Sec and EEFSEC:GDP by EEFSEC R-HSA-141673 GTP Hydrolysis by eRF3 bound to the eRF1:mRNA:polypeptide:80S Ribosome complex R-HSA-927889 SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) R-HSA-1799329 Signal peptidase hydrolyzes signal peptide from ribosome-associated nascent protein R-HSA-1799330 The SRP receptor binds the SRP:nascent peptide:ribosome complex R-HSA-1799326 Signal-containing nascent peptide translocates to endoplasmic reticulum R-HSA-72689 Formation of a pool of free 40S subunits R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane R-HSA-9010553 Regulation of expression of SLITs and ROBOs R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72695 Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72649 Translation initiation complex formation R-HSA-72737 Cap-dependent Translation Initiation R-HSA-8868773 rRNA processing in the nucleus and cytosol R-HSA-156902 Peptide chain elongation R-HSA-2408557 Selenocysteine synthesis R-HSA-72764 Eukaryotic Translation Termination R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-72766 Translation R-HSA-376176 Signaling by ROBO receptors R-HSA-192823 Viral mRNA Translation R-HSA-72702 Ribosomal scanning and start codon recognition R-HSA-156827 L13a-mediated translation R-HSA-72662 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72613 Eukaryotic Translation Initiation R-HSA-72312 rRNA processing R-HSA-156842 Eukaryotic Translation Elongation R-HSA-2408522 Selenoamino acid metabolism R-HSA-927802 Nonsense-Mediated Decay (NMD) R-HSA-392499 Metabolism of proteins R-HSA-422475 Axon guidance R-HSA-168273 Influenza Viral RNA Transcription and Replication R-HSA-8953854 Metabolism of RNA R-HSA-71291 Metabolism of nitrogenous molecules R-HSA-1266738 Developmental Biology R-HSA-168255 Influenza Life Cycle R-HSA-1430728 Metabolism R-HSA-168254 Influenza Infection R-HSA-5663205 Infectious disease R-HSA-1643685 Disease
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
