ID:GOLI_HUMAN DESCRIPTION: RecName: Full=E3 ubiquitin-protein ligase RNF130; EC=6.3.2.-; AltName: Full=Goliath homolog; Short=H-Goliath; AltName: Full=RING finger protein 130; Flags: Precursor; FUNCTION: May have a role during the programmed cell death of hematopoietic cells (By similarity). Acts as an E3 ubiquitin- protein ligase. PATHWAY: Protein modification; protein ubiquitination. SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein (Potential). Cytoplasm. TISSUE SPECIFICITY: Ubiquitously expressed. Highly expressed in leukocytes. Not expressed in erythroblasts. PTM: In vivo measurements suggest this protein is glycosylated (PubMed:19159218). In contrast, in vitro experiments failed to detect glycosylation (PubMed:16549277). SIMILARITY: Contains 1 PA (protease associated) domain. SIMILARITY: Contains 1 RING-type zinc finger. SEQUENCE CAUTION: Sequence=AAF67007.1; Type=Frameshift; Positions=110, 116;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q86XS8
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
BC065244 - Homo sapiens ring finger protein 130, mRNA (cDNA clone IMAGE:6065399), partial cds. AF155650 - Human mRNA for goliath protein. BC017100 - Homo sapiens ring finger protein 130, mRNA (cDNA clone IMAGE:3535930), partial cds. AY083998 - Homo sapiens goliath protein mRNA, complete cds. AB209800 - Homo sapiens mRNA for ring finger protein 130 variant protein. BC108306 - Homo sapiens ring finger protein 130, mRNA (cDNA clone MGC:117241 IMAGE:6137501), complete cds. BC082267 - Homo sapiens ring finger protein 130, mRNA (cDNA clone IMAGE:6731754), complete cds. BC113864 - Homo sapiens ring finger protein 130, mRNA (cDNA clone MGC:138647 IMAGE:40033418), complete cds. BC114472 - Homo sapiens ring finger protein 130, mRNA (cDNA clone IMAGE:40033417), partial cds. AK313089 - Homo sapiens cDNA, FLJ93572, Homo sapiens goliath protein (GP), mRNA. KJ902885 - Synthetic construct Homo sapiens clone ccsbBroadEn_12279 RNF130 gene, encodes complete protein. KJ899199 - Synthetic construct Homo sapiens clone ccsbBroadEn_08593 RNF130 gene, encodes complete protein. JD361341 - Sequence 342365 from Patent EP1572962. DL492694 - Novel nucleic acids. JD019382 - Sequence 406 from Patent EP1572962. JD035982 - Sequence 17006 from Patent EP1572962. JD455641 - Sequence 436665 from Patent EP1572962. JD035317 - Sequence 16341 from Patent EP1572962. JD024225 - Sequence 5249 from Patent EP1572962. JD036305 - Sequence 17329 from Patent EP1572962. JD022111 - Sequence 3135 from Patent EP1572962. JD022112 - Sequence 3136 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q86XS8 (Reactome details) participates in the following event(s):
R-HSA-983157 Interaction of E3 with substrate and E2-Ub complex R-HSA-983147 Release of E3 from polyubiquitinated substrate R-HSA-983140 Transfer of Ub from E2 to substrate and release of E2 R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983169 Class I MHC mediated antigen processing & presentation R-HSA-1280218 Adaptive Immune System R-HSA-168256 Immune System
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
