Human Gene RMND5A (ENST00000283632.5_4) from GENCODE V47lift37

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Description: required for meiotic nuclear division 5 homolog A (from RefSeq NM_022780.4)
Gencode Transcript: ENST00000283632.5_4
Gencode Gene: ENSG00000153561.13_7
Transcript (Including UTRs)
Position: hg19 chr2:86,947,414-87,005,164 Size: 57,751 Total Exon Count: 9 Strand: +
Coding Region
Position: hg19 chr2:86,947,791-87,000,534 Size: 52,744 Coding Exon Count: 9

Page Index	Sequence and Links	UniProtKB Comments	Primers	MalaCards	CTD
Gene Alleles	RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species
GO Annotations	mRNA Descriptions	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr2:86,947,414-87,005,164)			mRNA (may differ from genome)		Protein (391 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	Malacards	MGI	OMIM	PubMed	UniProtKB
BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: RMD5A_HUMAN DESCRIPTION: RecName: Full=Protein RMD5 homolog A; SIMILARITY: Contains 1 CTLH domain. SIMILARITY: Contains 1 LisH domain.

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

MalaCards Disease Associations


	MalaCards Gene Search: RMND5A Diseases sorted by gene-association score: meningoencephalocele (8), usher syndrome, type 1b (1)

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D000082 Acetaminophen D017638 Asbestos, Crocidolite D002994 Clofibrate D003300 Copper D019327 Copper Sulfate D004041 Dietary Fats D004397 Fonofos D006861 Hydrogen Peroxide D058185 Magnetite Nanoparticles D010100 Oxygen more ... click here to view the complete list

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 53.01 RPKM in Brain - Cerebellar Hemisphere Total median expression: 525.39 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-218.00	377	-0.578	Picture	PostScript	Text
3' UTR	-1275.80	4630	-0.276	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR013144 - CRA_dom
IPR024964 - CTLH/CRA
IPR006595 - CTLH_C
IPR006594 - LisH_dimerisation
IPR013083 - Znf_RING/FYVE/PHD

Pfam Domains:
PF10607 - CTLH/CRA C-terminal to LisH motif domain
PF13445 - RING-type zinc-finger

SCOP Domains:
57850 - RING/U-box

ModBase Predicted Comparative 3D Structure on Q9H871


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	Genome Browser
Gene Details	Gene Details		Gene Details		Gene Details
Gene Sorter	Gene Sorter		Gene Sorter		Gene Sorter
	RGD				SGD
					Protein Sequence
					Alignment

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0005515 protein binding GO:0004842 ubiquitin-protein transferase activity Biological Process: GO:0016567 protein ubiquitination GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process Cellular Component: GO:0005634 nucleus GO:0005737 cytoplasm GO:0034657 GID complex

Descriptions from all associated GenBank mRNAs


	BC069048 - Homo sapiens anaphase promoting complex subunit 1 pseudogene, mRNA (cDNA clone IMAGE:4111322), complete cds. AK023972 - Homo sapiens cDNA FLJ13910 fis, clone Y79AA1000131. AK022815 - Homo sapiens cDNA FLJ12753 fis, clone NT2RP2001226. BC047668 - Homo sapiens required for meiotic nuclear division 5 homolog A (S. cerevisiae), mRNA (cDNA clone MGC:51764 IMAGE:6066798), complete cds. JD201799 - Sequence 182823 from Patent EP1572962. BC012165 - Homo sapiens required for meiotic nuclear division 5 homolog A (S. cerevisiae), mRNA (cDNA clone MGC:20406 IMAGE:4636136), complete cds. JD192093 - Sequence 173117 from Patent EP1572962. CU680248 - Synthetic construct Homo sapiens gateway clone IMAGE:100017636 5' read RMND5A mRNA. CU690448 - Synthetic construct Homo sapiens gateway clone IMAGE:100021420 5' read RMND5A mRNA. HQ448707 - Synthetic construct Homo sapiens clone IMAGE:100072151; CCSB007218_01 required for meiotic nuclear division 5 homolog A (S. cerevisiae) (RMND5A) gene, encodes complete protein. KJ894576 - Synthetic construct Homo sapiens clone ccsbBroadEn_03970 RMND5A gene, encodes complete protein. KJ899476 - Synthetic construct Homo sapiens clone ccsbBroadEn_08870 RMND5A gene, encodes complete protein. AB528949 - Synthetic construct DNA, clone: pF1KB6542, Homo sapiens RMND5A gene for required for meiotic nuclear division 5 homolog A, without stop codon, in Flexi system. EU831557 - Synthetic construct Homo sapiens clone HAIB:100066586; DKFZo004F1218 required for meiotic nuclear division 5 homolog A (S. cerevisiae) protein (RMND5A) gene, encodes complete protein. EU831470 - Synthetic construct Homo sapiens clone HAIB:100066499; DKFZo008F1217 required for meiotic nuclear division 5 homolog A (S. cerevisiae) protein (RMND5A) gene, encodes complete protein. AK025448 - Homo sapiens cDNA: FLJ21795 fis, clone HEP00531. AK303113 - Homo sapiens cDNA FLJ54209 complete cds. AL832022 - Homo sapiens mRNA; cDNA DKFZp451I054 (from clone DKFZp451I054). JD337132 - Sequence 318156 from Patent EP1572962. JD350167 - Sequence 331191 from Patent EP1572962. JD149535 - Sequence 130559 from Patent EP1572962. JD117590 - Sequence 98614 from Patent EP1572962. JD338307 - Sequence 319331 from Patent EP1572962. JD269006 - Sequence 250030 from Patent EP1572962. JD054159 - Sequence 35183 from Patent EP1572962. AL050139 - Homo sapiens mRNA; cDNA DKFZp586M141 (from clone DKFZp586M141). JD314377 - Sequence 295401 from Patent EP1572962. JD355127 - Sequence 336151 from Patent EP1572962. JD277557 - Sequence 258581 from Patent EP1572962. JD482493 - Sequence 463517 from Patent EP1572962. JD184063 - Sequence 165087 from Patent EP1572962. JD276089 - Sequence 257113 from Patent EP1572962. JD496290 - Sequence 477314 from Patent EP1572962. JD250920 - Sequence 231944 from Patent EP1572962. JD539481 - Sequence 520505 from Patent EP1572962. JD262915 - Sequence 243939 from Patent EP1572962. JD502695 - Sequence 483719 from Patent EP1572962. JD038029 - Sequence 19053 from Patent EP1572962. JD172244 - Sequence 153268 from Patent EP1572962.

Other Names for This Gene


	Alternate Gene Symbols: D6W5M6, ENST00000283632.1, ENST00000283632.2, ENST00000283632.3, ENST00000283632.4, NM_022780, Q6NTF0, Q9H6W5, Q9H871, Q9H9H2, RMD5A_HUMAN, uc317kda.1, uc317kda.2 UCSC ID: ENST00000283632.5_4 RefSeq Accession: NM_022780.4 Protein: Q9H871 (aka RMD5A_HUMAN)

Gene Model Information


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Methods, Credits, and Use Restrictions


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