ID:RLF_HUMAN DESCRIPTION: RecName: Full=Zinc finger protein Rlf; AltName: Full=Rearranged L-myc fusion gene protein; AltName: Full=Zn-15-related protein; FUNCTION: May be involved in transcriptional regulation. SUBUNIT: Interacts with RIT1 and RIT2 (By similarity). INTERACTION: Q92963:RIT1; NbExp=3; IntAct=EBI-958266, EBI-365845; P70425:Rit2 (xeno); NbExp=2; IntAct=EBI-958266, EBI-2649620; SUBCELLULAR LOCATION: Nucleus (Probable). TISSUE SPECIFICITY: Widely expressed in fetal and adult tissues. MISCELLANEOUS: In some small cell lung carcinoma (SCLC) cell lines, there is an intrachromosomal rearrangements at 1p32 fusing the first exon of the RLF gene with L-myc. SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein family. SIMILARITY: Contains 14 C2H2-type zinc fingers.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q13129
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0003676 nucleic acid binding GO:0003677 DNA binding GO:0005515 protein binding GO:0008270 zinc ion binding GO:0046872 metal ion binding
Biological Process: GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0015074 DNA integration GO:0044030 regulation of DNA methylation GO:0045893 positive regulation of transcription, DNA-templated GO:0045944 positive regulation of transcription from RNA polymerase II promoter GO:0051276 chromosome organization GO:0097692 histone H3-K4 monomethylation
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
